acc 101 - a workshop for (new) animal care committee members · 2013. 1. 31. · ccac national...
TRANSCRIPT
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ACC 101
CCAC National Workshop 2012 Presentation
Michael Baar, D.M.V.Assessment and Certification Program Director
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Mandate
“The purpose of the CCAC is to act in the interests of thepeople of Canada
to ensure through programs of education, assessment andpersuasion; the use of animals, where necessary, forresearch, teaching and testing
employs optimal physical and psychological care according toacceptable scientific standards and
to promote an increased level of knowledge, awareness andsensitivity to relevant ethical principles.”
CCAC By-Laws, (art. 4), May 27, 1998
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Distributed Management
Council
Members represent 24 national organizations
Secretariat
24 employees in Ottawa
> 220 institutional animal care committees
2000 volunteers
veterinarians, scientists, technicians, community
representatives
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CCAC Organizations
Animal Users
Agriculture and Agri-Food
Canada
Department of NationalDefence
Environment Canada
Department of Fisheries andOceans
Health Canada
National Research Council
Association of Canadian
Faculties of Dentistry
Association of Faculties of
Medicine of Canada
Association of Universities
and Colleges of Canada
Canada's Research-Based
Pharmaceutical Companies
Canadian Council ofDepartments of Psychology
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CCAC Organizations
Canadian Society ofZoologists
Confederation of CanadianFaculties of Agriculture andVeterinary Medicine
National Cancer Institute ofCanada
Welfare Organizations
Canadian Federation ofHumane Societies
Canadian Association forLaboratory Animal Medicine
Canadian Association forLaboratory Animal ScienceCanadian Bioethics Society
Canadian Veterinary MedicalAssociation
Research Funders
Canadian Institutes of HealthResearch
Natural Sciences andEngineering ResearchCouncil
Heart and Stroke Foundationof Canada
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CCAC Programs
The CCAC includes 4integrated,interdependent programs,which involve communityrepresentatives and theanimal welfare movementin addition toveterinarians, scientistsand animal healthtechnicians
Education,Training &
CommunicationsGuidelines
Development
Assessment Three Rs
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Education,Training &Communications
CCAC website and yearly National Workshops (April 26-27, 2012)
The CCAC guidelines on: institutional animal usertraining :12 web-based modules are provided by theCCAC as resource material. New fish modules!
Webinars, and other resources and training materialsprovided on the CCAC website
Annual Animal Use Data
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CCAC guidelines on:
choosing an appropriateendpoint (1998)institutional animal usertraining (1999)antibody production (2002)care and use of wildlife(2003)laboratory animal facilities(2003)care and use of fish (2005)animal procurement (2008)care and use of farmanimals (2009)euthanasia (2010)
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Guidelines Under Development
UPDATES
genetically engineered animals
care and use of rats
institutional animal user training
non-human primates
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Guidelines Under Development
NEW
the care and maintenance of marine mammalsin captivity
air quality in laboratory animal facilities
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Three Rs Program
Two main focuses:
Promotion of the Three Rs
Implementation of the Three Rs
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Three Rs: Replacement, Reduction,Refinement
Three Rs microsite onCCAC website
Three Rs Search Guide
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CCAC Assessment Program
Consultative and collaborative peer reviewprocess through participation of volunteers
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Same Criteria Used for All Assessments
CCAC guidelines, policies andrecognized standards
Standard Animal Care and UseProgram Review Form (PRF),filled out by the institution aspre-assessment documentation,to ensure consistency betweenassessments and equallythorough assessments
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Elements Assessed
Animal care committee
Infrastructure of animal
housing facilities
Animal care and facility
management
Veterinary care
Training and continuing
education
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Animal Care Committees (ACCs)
ACC: KEYSTONE OF THE CCAC SYSTEM
Function: Quality Control
Responsibilities: ensure optimal levels of animalcare and ethical animal use
Must be at the centre of any animal care anduse program, working with all stakeholders
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Animal Care Committee
Reporting lineReport to the institutional senior administrator (VP Research)
Composition:Animal users from all main parts of the institution
Veterinarian(s)
Community representative(s)
Facility manager(s)/representative(s) from animal care staff
Institutional non-animal user
Student representative(s) (graduate/undergraduate, user or non)
ACC coordinator
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Responsibilities of the ACC
Main responsibilities are:
Protocol review, approval
Follow-up (post-approval monitoring)
Annual site visit
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Tools for Protocol Review
An animal use protocol form
CCAC guidelines and policies and associated documents
Institutional policies and standard operating procedures(SOPs)
The expertise, judgment and common sense of committeemembers
Additional resources and expertise as necessary
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Animal Use Protocol Form
Each institution must develop an animal use protocol formthat suits the nature and culture of the institution, whileincluding all elements required by the CCAC for a completeethical review
All elements must be presented by scientists/teachers in alanguage that is easily understood by all ACC members,including community representatives
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General Identification
Project title and descriptive keywords, or briefprotocol description
Author and all personnel who will handleanimals (students, staff)
Training and qualifications
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General Identification
Departmental affiliation
Proposed start date
Proposed end date
Lay summary
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General Identification
Funding source(s) and status of funding approval
Peer review of scientific merit for research projects
Pedagogical merit for teaching protocols
Current regulatory guidelines for testing protocols
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Specific Information
Use of hazardous agents
institutional approval of this use
Categories of invasiveness (cumulative)
Purpose of animal use
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Specific Information
Alternatives:
Replacement
Reduction
Refinement (including environmental enrichment)
Species and numbers of animals to be used peryear, and justification thereof
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Procedures
A description detailing the procedures that arecarried out on the animals (flow charts)
Anesthesia and analgesia, including:
dosages
methods of use (when to start, how often)
Justification for not using anesthesia oranalgesia, if relevant
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Procedures
A description of the endpoint(s) of the experimentation
selected according to the CCACguidelines on: choosing anappropriate endpoint in experimentsusing animals for research, teachingand testing, 1998
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Procedures
A description of capture, restraint, transportationand/or housing of animals used in field studies
Any other information pertinent to field studies,such as capture permits, capture of non-targetspecies and potential injuries or mortality duringcapture or transportation, if relevant
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Procedures
The method of euthanasia, if used
justification for any physical euthanasia methods
or for any methods that deviate from those describedin the CCAC guidelines on: euthanasia of animalsused in science (2010)
A description of how the animals will bedisposed of if they are not to be euthanized
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Procedures
Any other information considered important ornecessary and pertinent
including information or results derived from anyrelevant previous protocols
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Responsibilities of the ACC
Main responsibilities are:
Protocol review, approval
Follow-up (post-approval monitoring)
Annual site visit
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Post-Approval Monitoring (PAM)
Objective
To ensure animal use protocols and standardoperating procedures are applied in practice asapproved in principle by the Animal CareCommittee (ACC).
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How to meet the objective?
Having a formal, documented and effective PAMprogram in place
PAM Program: combination of policies, practicesand procedures designed to manage risk
Risk: probability of a certain event X impact ofthat event
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Risk factors
communication between stakeholders
training/support of animal users
animal facilities and laboratories
new or difficult projects, protocols or procedures
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An ounce of prevention…
… is worth a pound of cure!!
Create conditions for ethical and successful animal-based projects:
Solid structure for animal care and use program
Effective ACC
Complete veterinary and animal care services
Comprehensive training and evaluation of competency
Sufficient and appropriate facilities and equipment
Frequent and open communications
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Best practices
ACC at centre of PAM
Tailored to meet the needs of your institution
Goldilocks rule: not too complex or too simple
Based on risk assessment : Pareto’s principle
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Best practices
Support of senior administration
Involve peers in lab visits (ACC members)
Shelter clinical veterinarians
Think about non-compliance issues
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Responsibilities of the ACC
Main responsibilities are:
Protocol review, approval
Follow-up (post-approval monitoring)
Annual site visit
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Annual Site Visits Help the ACC…
Better understand the work being conducted within the institution
Ensure that the facilities, equipment and human resources areappropriate and sufficient
Meet with those working in the animal facilities and animal useareas
Observe any procedures identified as potential issues by ACC
Make recommendations and commendations to thoseresponsible for the facilities and for animal use
Ensure compliance with approved protocols (as part of PAM)
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Site Visits Should:
Be conducted at each facility at least oncea year
Be documented through ACC minutes, orpreferably through written reports
Include each ACC member on at least onesite visit a year
Include all holding, procedure and serviceareas of the animal facilities, andresearchers’ laboratories whereprocedures are done (even if only acuteprocedures)
Include off-site or off-campus facilities
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Four Pillars
Strategic planning
Management
Staffing
Infrastructure
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Strategic Planning
Facilities should:
Serve the needs and interests of the institutionas a whole
Be flexible and adaptable to evolving research
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Strategic Planning
Facilities should:
Be conducive to the well-being and safety ofthe animals
Provide an appropriately-appointed and safeworkplace for personnel
Establish a stable research environment
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Management
Consistency and excellence through theuniform application of best practices (SOPs)
Well trained and competent managers witheffective and unencumbered reporting lines toavoid any potential conflict of interest
Opportunities for ongoing and relevantcontinuing education
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Staffing
Sufficient numbers of well trainedand competent veterinary andanimal care staff with effective andunencumbered reporting lines toavoid any potential conflict ofinterest
Continuing educationalopportunities
Animal care staff responsible forhealth and welfare of animals inthe service of high quality science
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Housing space
Procedure space
Service and storage areas
Infrastructure
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Before You Enter an Animal Facility
1. Do you have allergies?
2. Will you be exposed to any risks(biological, chemical etc)?
3. When were you last in another animalfacility?
4. Will you enter barrier areas?
5. Are sensitive protocols under way?
6. Will you be using a checklist?
7. Be prepared to ask a lot of questions!
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Upon Entering
STOP → follow PPE requirements, log in procedures
SMELL → Ventilation problems?
LOOK → General conditions, sanitation
LISTEN → Noise, vibrations?
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Animal Identification and Records
Individual animals identified
Cage/rack/pen/tank cards containrequired information in standard format
Clinical records accessible andappropriate
Genetic records & monitoringprocedures
Records to be kept for a period of oneyear after final disposition of animal
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Before Leaving
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After the Visit
Document visit
Forward any recommendations or commendations
Expect a written formal response
Joint follow up (paper trail in meeting minutes)
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ACC 101
Special thanks to Dr. Ronald Charbonneau
Questions?