Acetyl-CoA Carboxylase-A New Target in the Fight against

ObesityNaida Idrizovic

What is Obesity?

Obesity is a chronic disease with excessive body fat. This is a leading disease of the 21st century in the U.S.

Obesity is determined by the body mass index(BMI).

Diseases that are caused from Obesity is type 2 diabetes, high cholesterol, heart failure, disability and more.

Warning!

Having a skinny body doesn’t mean that

A person is healthy. It means that the person has a low BMI but may carry lots of body fat.

WARNING FOR OBESITY: Family member who died from heart

disease. You can still be slim and not workout, but

not exercising will have an impact on healthy life.

Eating junk food can prevent your body from absorbing vitamins and nutrients.

Malonyl-CoA is important!

Malonyl-coA is important because it has two functions in metabolism.

1. Plays a role in fatty-acid synthesis2. Inhibits carnitine palmitoyltransferase I for

fatty-acid oxidation to occur.In the cytosol Malonyl-CoA determines if the

fatty-acid will be oxidized or if it will just store fats

Acetyl-coA carboxylase

Carboxylase is an enzyme that comes in two isoforms and are encoded by different genes. This enzyme produces Malonyl-CoA carboxyalse.

1. ACC1- is in the liver and adipose tissue2. ACC2- is in the skeletal muscle and

cardiac

Experiment on ACC1 and ACC2

ACC1 and ACC2 are the main enzymes in lipid metabolism. An experiment was conducted using mice to analyze the enzymes further and to compare ACC1 and ACC2.After the experiment was complete, the conclusion was that ACC2 played a role in decreasing intracellular fatty acids when glucose activates ACC2.

AMP-dependent protein Kinase

Amp-dependent protein kinase is a negative target for insulin and type 2 diabetes.

ACC2 is inactivated by the enzyme AMPK. This becomes resistant to insulin ,and it increases fatty acid.There is a connection between AC2 and AMPK. By activating the AMPK there is an increase in glucose and fatty acid oxidation.

Conclusion! =)

In conclusion ACC2 reduce fatty acid synthesis and removes the block on carnitine palmitoyltransferase 1. Due to this it

decreases body weight. This is why it is believed that ACC2 would be a great target for drugs used to fight obesity.

References

http://www.obesity.org/resources-for/what-is-obesity.htm

http://www.doctoroz.com/videos/are-you-secretly-obese

http://www.ncbi.nlm.nih.gov/pubmed/19618481http://

www.jlr.org/content/50/Supplement/S138.fullM. Campbell and S. Farrell Biochemistry book

7th edition

THANK YOU AND HAVE A GREAT SUMMER =)