acoustic properties of tissue fall 2019 · 2019. 11. 13. · rad225/bioe225 ultrasound acoustic...
TRANSCRIPT
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Rad225/Bioe225UltrasoundFall 2019Acoustic Properties of Tissue
1
✦ Intensity✦ Speed of Sound✦ Acoustic Impedance✦ Attenuation✦ Intensity
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Rad225/Bioe225UltrasoundFall 2019Intensity
I ∝P2
2
Intensity is the power transferred per unit area (W/m2)
Iave
P
I
will come back to this at end of lecture
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Rad225/Bioe225UltrasoundFall 2019Acoustic Properties of Tissue
3
✦ Intensity✦ Speed of Sound✦ Acoustic Impedance✦ Attenuation✦ Intensity
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Rad225/Bioe225UltrasoundFall 2019Particle Velocity vs
Compression Wave Velocity
�4
u = particle velocity
c = compression wave velocity (SoS)
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Rad225/Bioe225UltrasoundFall 2019κ determines speed of sound
�5
high κ
higher c
lower c
low κ
κ=compressibility
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Rad225/Bioe225UltrasoundFall 2019Bulk Modulus
�6
B = dPdV−V
⎛⎝⎜
⎞⎠⎟
B = Bulk Modulus = measure of the stiffness (Pa) - resistance to being compressedB = 1/κ where κ=compressibility
high κ or Low B
low κ or High B
higher c
lower c
ratio of infinitesimal pressure increase to the resulting relative decrease in the volume
u<c
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Rad225/Bioe225UltrasoundFall 2019Acoustic Velocity/Speed of Sound
c2 = 1κρ
B = Bulk Modulus = measure of the stiffness (Pa)B = 1/κ where κ=compressibilityρ = density (kg/m3)
�7
c = Bρ
ρ(kg/m3) B(MPa)c(m/s) Air(25°C) 1.16 0.137344 Fat 928 19001430 Water(22°C) 998 21901482 Blood 1060 26601584 Skeletalmuscle1041 26001580 Liver 1050 26101578 Kidney 1050 25601560 Bone 1600 181003360
BulkModulus
SpeedofSoundDensity
Szabo
c2 = Bρ
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Rad225/Bioe225UltrasoundFall 2019Speed of Sound
The pulse moves through tissue at a velocity specific to the tissue and independent of the applied frequency.
f = 3.0
MHz
f = 1.5
MHz
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Rad225/Bioe225UltrasoundFall 2019Speed of Sound
The pulse moves through tissue at a velocity specific to the tissue and independent of the applied frequency.
• Velocity (c), frequency (f), and wavelength (λ) are related:
• c = λ f
λ =
0.5 mmλ =
1 mm
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Rad225/Bioe225UltrasoundFall 2019c in soft tissue
1540 m/s = 1 MHz * 1.54 mm
What is the wavelength for 500 kHz ultrasound in soft tissue?~ 3 mm
Why does this matter?
1) resolution ~ wavelength⇒ higher frequency gives better resolution
we’ll talk about this more later
2) phase aberrations
10
c = fλ
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There is a wavelength change due to the
speed of sound change in bone
There is more attenuation in the
thicker bone
Two elements of the 1000 transducer array elements
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There is a wavelength change due to the
speed of sound change in bone
These two beams are out of phase
at the target
There is more attenuation in the
thicker bone
This beams has a phase of φ1
This beams has a phase of φ2
At the target:
1
-1
The sum is not as great as it could be
12
Two elements of the 1000 transducer array elements
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These two beams are in phase at the
target
-φ1
-φ2
1
-1
The sum is now bigger
Phase Aberration Correction
13
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Rad225/Bioe225UltrasoundFall 2019Acoustic Properties of Tissue
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✦ Intensity✦ Speed of Sound✦ Acoustic Impedance✦ Attenuation✦ Intensity
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Rad225/Bioe225UltrasoundFall 2019Example
15
Sound echo off a wallThe wall has a different property from the air
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Rad225/Bioe225UltrasoundFall 2019Acoustic Impedance
• At each interface, some sound is reflected and some is transmitted.
• The relative amounts depend on the acoustic impedances Z1 and Z2.
Transducer
Z1
Z2
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Rad225/Bioe225UltrasoundFall 2019Acoustic Impedance
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Z = Pu
P is the pressureu is the particle velocitythink of it like resistance
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Rad225/Bioe225UltrasoundFall 2019Acoustic Impedance
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Z = BρB = −V dP
dVB = Bulk Modulus = measure of the stiffness (Pa)B = 1/κ where κ=compressibility
ratio of infinitesimal pressure increase to the resulting relative decrease in the volume
c = Bρ
Z = ρc
and using
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Rad225/Bioe225UltrasoundFall 2019Acoustic Impedance
19
ρ(kg/m3) c(m/s)Z(106kg/m2/s)Air(25°C) 1.16 344 0.0004Water(22°C) 998 1482 1.48Blood 1060 1584 1.68Skeletalmuscle1041 1580 1.65Liver 1050 1578 1.64Kidney 1050 1560 1.64Fat 928 1430 1.33Bone 1600 3360 5.69
Impedance(MRayl)
SpeedofSoundDensity
Z = ρc
Szabo
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Rad225/Bioe225UltrasoundFall 2019
Acoustic Impedance Z Transducer
Z1
Z2
%reflection = 100*Z2 − Z1( )2Z2 + Z1( )2
%transmitted = 100*4 * Z1Z2Z2 + Z1( )2
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Rad225/Bioe225UltrasoundFall 2019Reflection Examples
21
• What is the reflection at a fat-muscle interface?reflection = 100*(1.7-1.38)2/(1.7+1.38)2 = 1.1%
• What is the reflection at a muscle-bone interface?reflection = 100*(7.8-1.7)2/(7.8+1.7)2= 41%
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Rad225/Bioe225UltrasoundFall 2019Acoustic Properties of Tissue
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✦ Intensity✦ Speed of Sound✦ Acoustic Impedance✦ Attenuation✦ Intensity
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Rad225/Bioe225UltrasoundFall 2019Attenuation
α =α a +α sαa = attenuation due to absorption
αs = attenuation due to scattering
P(z,t) = P0ei(wct−kz )e−αz
For a single frequency plane wave,
α is given in nepers/cm
z(cm)
P(z)
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Rad225/Bioe225UltrasoundFall 2019Attenuation
α =α a +α s
αa = attenuation due to absorption - dominates in soft tissue
αs = attenuation due to scattering - dominates in medullary bone
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Rad225/Bioe225UltrasoundFall 2019Attenuation
Two sources: 1) reflection and scatter and 2) absorption (heat)
Loss of signalWorse at high frequency
loss of signal as the sound wave travels through the tissue
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Rad225/Bioe225UltrasoundFall 2019dB
�26
SignalLevel(dB) = 10 log I2I1
Relative
SignalLevel(dB) = 10 log PP0
⎛⎝⎜
⎞⎠⎟
2
Relative
SignalLevel(dB) = 20 log PP0
⎛⎝⎜
⎞⎠⎟
Relative
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Rad225/Bioe225UltrasoundFall 2019Relative Sound Intensity
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when I = 0.5 Io, relative sound intensity is -3 dBwhen I = 0.1 Io, relative sound intensity is -10 dB
multiply add
when I = 0.25 Io, relative sound intensity is -6 dBwhen I = 0.001 Io, relative sound intensity is -30 dB
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Rad225/Bioe225UltrasoundFall 2019Attenuation in dB
α dBz = 20 log10 (PP0)
lossdB = 20 log10 (loss)
α dB =1z20 log10 (e
−αnepersz )
α dB = 8.6886α nepers
28
P(z,t) = P0e−αz
lossdb =α dbz
You can use eitherlogb(x) =loga (x)loga (b)
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Rad225/Bioe225UltrasoundFall 2019Attenuation
�29
Material α(dB/cm/MHz)Water 0.0022Blood 0.14Liver 0.45Muscle 1Soft Tissue 0.5Air 12Bone 10
attenuation (dB) = α f zα = attenuation coefficient
f = frequency in MHz
z = distance in cm
Duck
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Rad225/Bioe225UltrasoundFall 2019Attenuation Examples
• A 5 MHz beam passes thru 6 cm of tissue. The intensity is attenuated by how much?
attenuation = -1 dB/cm/MHz * 5MHz * 6cm
= -30dB
The received signal is 1/1,000 the transmitted signal.
Usually receive 1/1,000,000 the transmitted signal.
attenuation (dB) = α f z
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Attenuation Examples
How does this limit depth reception? If we have a -60 dB dynamic range and operate @5MHz, then depth is set:
-60dB = -1 dB/cm/MHz * x cm * 2 * 5 MHz
depth = 6 cm
• For imaging deeper, need lower frequency
• More superficial structures, can use a higher frequency
Stanford’s Ultrasound units are typically set to filter out signals <-60dB. What effect does this have?
It reduces some artifacts, but also limits depth reception.
attenuation (dB) = α f z
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Rad225/Bioe225UltrasoundFall 2019Time Gain Control
TGC - Amplifies the signal based on its depth - equalizes the signal across the image.
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Rad225/Bioe225UltrasoundFall 2019Artifactual Enhancement
• Some structures do not have much attenuation - cysts, bladder.• Can have high signal beyond these structures. “Acoustic Window”
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Rad225/Bioe225UltrasoundFall 2019Acoustic enhancement
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Artifact1: WhatiscausingthisLiverLesion?
PoorlyadjustedTime-GainCompensation
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more reflections from inhomgeneous fat/water liver
increasing fat content
attenuation of fat compared to aqueous liver
Artifact2: Whatiscausesincreasinglossofliversignal?
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Rad225/Bioe225UltrasoundFall 2019Acoustic Properties of Tissue
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✦ Intensity✦ Attenuation✦ Speed of Sound✦ Acoustic Impedance✦ Intensity
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Rad225/Bioe225UltrasoundFall 2019Intensity
I = P2
Z
38
Intensity is the power transferred per unit area (W/m2)Intensity = power density
powerdensity = powerarea
= workarea* time
= force*dis tancearea* time
powerdensity = P* particlevelocity Z = Pu
Instantaneous
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Rad225/Bioe225UltrasoundFall 2019Intensity
39
Iave
P
I
I = P2
Z
Iave =P2
2Ztime average
Instantaneous