acquity uplc systems and third-party ms...sciex analyst software. acquity uplc systems will run in...
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[ product solution ]
AC QU IT Y U P L C S YS T EMS A N D T H I R D - PA RT Y MS
The only inlet you need for mass spectrometry
EXT END YOUR MS SOLUT ION
Waters® ACQUITY UPLC® and nanoACQUITY UPLC® systems, in combination with Waters MS tech-
nologies, chemistries, informatics software, and support services, create a complete system solution
for cutting-edge UPLC®/MS and UPLC/MS/MS applications, yielding the ultimate in chromatographic
resolution, peak capacity and MS sensitivity. Optimal use of UPLC’s sub-2-micron particles results in
narrow peaks, higher signal-to-noise ratios, and shorter run times.
The unprecedented benefits of UPLC technology have driven the need for direct integration of
chromatographic control and data acquisition of ACQUITY UPLC and nanoACQUITY UPLC systems
with non-Waters mass spectrometers.
Extending the ability of UPLC technology to operate seamlessly with other mass spectrometers
provides laboratories with greater analytical performance advantages that result in better use of
existing MS investments.
More resolution, sensitivity, and speed: The power of UltraPerformance LC®, as demonstrated in this HPLC/MS vs. UPLC/MS analysis of the hydroxylated metabolites of Buspirone.
ACQUITY UPLC and
nanoACQUITY UPLC
systems can improve
performance with the
following third-party
MS systems:
Applied Biosystems/
MDS SCIEX:
QSTAR, Q TRAP, and API
series mass spectrometers
Thermo Fisher Scientific:
TSQ Quantum, LTQ Linear Ion
Trap, LTQ FT Hybrid Linear
Trap/Fourier Transform ICR,
and LTQ Orbitrap Hybrid
mass spectrometers
Bruker Daltonics:
esquire/HCT, micrOTOF,
apex, and UltrOTOF series
mass spectrometers
and Bruker BioSpin
NMR spectrometers
HPLC/MS Column: 2.1 x 50, 3.5 μm
Flow rate: 300 μL/min
Analysis time: 5 min
Buspiron, Human T90, QPMS Scan, 50 mm, 40 °C, 300R2HPLC300_BS_MSScan_40C50mm0519008 Sm (Mn, 2x1)
MS2 ES+402
3.95e7
Time
100
%
00.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00
3.83
4.09
4.39
3.65
3.35
3.21
MS2 ES+402
3.95e7
Time
100
%
0
Buspiron, Human T90, QPMS Scan, 50 mm, 40 °CQPBS_MSScan_40c50mm0504008 Sm (Mn, 2x1)
0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00
0.910.75
0.69
0.56
UPLC/MS Column: 2.1 x 50, 1.7 μm
Flow rate: 800 μL/min
Analysis time: 1 min
[ product solution ]
Applied Biosystems/MDS SCIEX
Analyst software* supports:
• ACQUITY UPLC and nanoACQUITY UPLC systems
• Q TRAP and API series mass spectrometers
Analyst QS** software supports:
• ACQUITY UPLC and nanoACQUITY UPLC systems
• QSTAR mass spectrometers
*ABI/MDS SCIEX Analyst software will support ACQUITY UPLC and nanoACQUITY UPLC system control in v.1.4.2 with Hotfix. Also offered is the ACQUITY UPLC Instrument Control Options Pack for ABI/MDS SCIEX Analyst software. ACQUITY UPLC systems will run in stand-alone mode under console-based control on the Analyst workstation.
**ABI/MDS SCIEX Analyst QS software will support ACQUITY UPLC and nanoACQUITY UPLC system control in v.2.0 with Hotfix.
E X P E R I ENC E T H E A NA LY T IC A L IM P ROV EM ENT S O F U P L C W IT H T H E MA S S S P EC T ROM E T E RS A N D S O F T WA R E YO U U S E E V E RY DAY
Analyst instrument method page.
Analyst acquisition method page.The ACQUITY UPLC console for easy stand-alone control and execution of UPLC/MS data sets.
ST REAMLINED, STAND-ALONE CONT ROL OF UPLC SYST EMS
Waters has developed a new, stand-alone console software applica-
tion for ACQUITY UPLC and nanoACQUITY UPLC systems, allowing
for flexible instrument method editing and sample set execution.
This ACQUITY UPLC console interfaces with a sample queue manager
capability that can run directly on the same PC workstation operating
third-party data systems, or can alternatively run on a separate,
dedicated PC.
Supported ACQUITY UPLC modules:
n Binary Solvent Manager
n Sample Manager
n Optional Sample Organizer
n Optional Tunable UV Detector
n Optional Photodiode Array Detector
n Optional Evaporative Light Scattering Detector
n Optional Column Manager
Supported nanoACQUITY UPLC modules:
n Binary Solvent Manager
n Sample Manager with Trapping and Heating Module
n Optional Auxiliary Solvent Manager
n Optional Tunable UV Detector
Thermo Fisher Scientific
Xcalibur software† supports:
• ACQUITY UPLC and nanoACQUITY UPLC systems
• TSQ Quantum, LTQ Linear Ion Trap, LTQ FT Hybrid Linear Trap/Fourier
Transform ICR, and LTQ Orbitrap Hybrid mass spectrometers
††Bruker HyStar software control in v.3.2, with an LC driver supplied by Bruker Daltonics, will support the ACQUITY UPLC system.
Bruker Daltonics
HyStar software†† supports:
• ACQUITY UPLC system
• esquire/HCT, micrOTOF, apex, and UltrOTOF series
mass spectrometers
• Bruker BioSpin NMR spectrometers
†Thermo Fisher Scientific Xcalibur software control is available from Thermo Fisher Scientific through an instrument driver that will work with Xcalibur v.2.0, SR2 for ACQUITY UPLC and nanoACQUITY UPLC systems.
E X P E R I ENC E T H E A NA LY T IC A L IM P ROV EM ENT S O F U P L C W IT H T H E MA S S S P EC T ROM E T E RS A N D S O F T WA R E YO U U S E E V E RY DAY
Xcalibur sample set page.
Xcalibur instrument method page.
HyStar acquisition page.
HyStar instrument method page.
[ product solution ]
Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com
FULL SYST EM INT EGRAT ION
A complete suite of advanced diagnostic capabilities and ease-of-
use tools are available in the ACQUITY UPLC console. The ACQUITY
UPLC BEH column’s eCord™ Information Management Technology
(not supported in nanoACQUITY UPLC system) tracks information
over the life of the column, including certificate of analysis, dates
of installation and usage, number of injections and sample sets, and
maximum temperature and pressure.
Users also have access to the ACQUITY UPLC console calculator to
simplify transfer and optimization of HPLC methods to UPLC methods.
Additionally, state-of-the-art Connections INSIGHT® intelligent
services provides automatic alerts on ACQUITY UPLC system usage
and performance parameters directly to Waters Technical Support
for proactive servicing, to ensure maximum uptime and system
performance.
ACQUIT Y UPLC systems and third-party MS – integration you can rely on
The ACQUITY UPLC console, integrated into non-Waters MS data
systems, provides the ultimate results for improved throughput,
sensitivity, specificity, accuracy, and resolution performance for any
LC/MS laboratory.
Waters, The Science of What’s Possible, ACQUITY, ACQUITY UPLC, nanoACQUITY UPLC, UltraPerformance LC, UPLC, eCord, Connections and Connections INSIGHT are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.
©2007 Waters Corporation. Printed in the U.S.A.April 2007 720002105EN LB-PC
ACQUITY UPLC system.