acrin annual meeting 2011 mitchell schnall md, phd professor of radiology university of pennsylvania...
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ACRIN Annual Meeting 2011
Mitchell Schnall MD, PhDProfessor of RadiologyUniversity of PennsylvaniaACRIN Network Chair
State of ACRIN : Extending our reach
ACRIN Annual Meeting 2011
ACRIN Scientific Strategy
1. Develop and evaluate strategies for imaging surveillance of populations at high risk for cancer.
2. Develop and validate imaging biomarkers to predict and monitor therapy response.
3. Evaluate the effectiveness of imaging directed therapy on improving patient management and associated outcomes. This includes comparative effectiveness studies of existing imaging methods.
ACRIN Annual Meeting 2011
ACRIN Organizational Chart
Institutional Participants CommitteeVice Chair
Chris Comstock, MDMemorial Sloan Kettering
Institutional Participants CommitteeVice Chair
Chris Comstock, MDMemorial Sloan Kettering
Media / Publications and
DisseminationCommitteeVice Chair
Laurie Fajardo, MDUniversity of Iowa
Media / Publications and
DisseminationCommitteeVice Chair
Laurie Fajardo, MDUniversity of Iowa
Special PopulationsElizabeth Patterson, MD
Special PopulationsElizabeth Patterson, MD
Research AssociatesWendy Smith, RT
Rhode Island Hospital
Research AssociatesWendy Smith, RT
Rhode Island Hospital
Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania
Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania
Patient AdvocacyPeggy Anthony, RN, MHS
Patient AdvocacyPeggy Anthony, RN, MHS
Outcomes & Economics Core
LaboratoryWilliam Black, MD
Dartmouth Medical School
Outcomes & Economics Core
LaboratoryWilliam Black, MD
Dartmouth Medical School
Advisory PanelDaniel Sullivan, MD
Duke University
Advisory PanelDaniel Sullivan, MD
Duke UniversityLeadership Council
Mitchell Schnall, MD, PhDUniversity of Pennsylvania
Leadership CouncilMitchell Schnall, MD, PhD
University of Pennsylvania
Biostatistical & Data Management Center
Chair Constantine Gatsonis, PhD
Brown University
Biostatistical & Data Management Center
Chair Constantine Gatsonis, PhD
Brown University
Steering Committee
Network ChairMitchell Schnall, MD, PhD
University of Pennsylvania
Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD
UCLA
Molecular ImagingBarry Siegel, MD
Washington University
Steering Committee
Network ChairMitchell Schnall, MD, PhD
University of Pennsylvania
Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD
UCLA
Molecular ImagingBarry Siegel, MD
Washington University
AbdominalTerri Wong, MDDuke University
AbdominalTerri Wong, MDDuke University
Head/Neck/CNSDan Barboriak,, MD
Duke University
Head/Neck/CNSDan Barboriak,, MD
Duke University
BreastConnie Lehman, MD
University of Washington
BreastConnie Lehman, MD
University of Washington
ThoracicCaroline Chiles, MDWake Forest University
ThoracicCaroline Chiles, MDWake Forest University
GynecologicalSusanna Lee, MD
Massachusetts General Hosp
GynecologicalSusanna Lee, MD
Massachusetts General Hosp
Disease SiteCommittees
Scientific SupportCommittees
Experimental ImagingDavid Mankoff, MD
University of Washington
Experimental ImagingDavid Mankoff, MD
University of Washington
InformaticsDaniel Rubin, MDStanford University
InformaticsDaniel Rubin, MDStanford University
Core Laboratory
PET/Nuc MedicineBarry Siegel, MD
Washington University
MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania
Core Laboratory
PET/Nuc MedicineBarry Siegel, MD
Washington University
MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania
Ultrasound Working Group
Barry Goldberg, MDThomas Jefferson University
Ultrasound Working Group
Barry Goldberg, MDThomas Jefferson University
NCIPaula Jacobs, PhD
Cancer Imaging Program
NCIPaula Jacobs, PhD
Cancer Imaging Program
Network AdministrationCharles Apgar
ACR Philadelphia
Network AdministrationCharles Apgar
ACR Philadelphia
Data & Safety Monitoring Committee
Daniel Sargent, PhDMayo Clinic
Data & Safety Monitoring Committee
Daniel Sargent, PhDMayo Clinic
SupportCommittees
Organizational Changes
Cardiovascular Pam Woodard, MDWashington University
Cardiovascular Pam Woodard, MDWashington University
ACRIN PAMitch Schnall, MD, PhD
University of Pennsylvania
ACRIN PAMitch Schnall, MD, PhD
University of Pennsylvania
NeuroscienceGreg Sorensen, MD
Massachusetts General Hosp
NeuroscienceGreg Sorensen, MD
Massachusetts General Hosp
ACRIN ProjectsMitch Schnall, MD, PhD
University of Pennsylvania
ACRIN ProjectsMitch Schnall, MD, PhD
University of Pennsylvania
Non NCI Disease SiteCommittees
ACRIN FoundationJim Thrall, MD
MGH
ACRIN FoundationJim Thrall, MD
MGH
Head/Neck/CNSDan Barboriak,, MD
Duke University
Head/Neck/CNSDan Barboriak,, MD
Duke University
Patient AdvocacyPeggy Anthony, RN, MHS
Patient AdvocacyPeggy Anthony, RN, MHS
ACRIN Annual Meeting 2011
Highlights: NLST publication
•20% redcution in lung cancer mortality•7% redcution in all cause mortality
ACRIN Annual Meeting 2011
Highlights: Study Portfolio
11 open studies 2 Cardiovascular (RESCUE is opened) 9 Oncology (first multicenter optical imaging trial) Comparative effectiveness studies (RESCUE, 6690)
5 concepts in development E2410 trial in collaboration with ECOG Collaboration with QIBA Diffusion MRI in ISPY 2
DECAMP: impact of biomarkers in risk assessment and diagnostics related to lung cancer screening
ACRIN Annual Meeting 2011
Highlight: CQIE
Goal: Qualify 59 cancer center in quantitative MRI, CT and PET imaging
Accomplishments 52 sites fully qualified
• CT:57
• PET: 54
• MR: 54
ACRIN Annual Meeting 2011
Mid Term Review
“Evaluation Committee members identified the Network as an invaluable national resource worthy of continued support” Screening program rated as exceptional Biomarkers program challenges acknowledged
• Smaller early phase studies
• Focus on compelling clinical problems (practice changing)
• Reduce trial complexity
ACRIN Annual Meeting 2011
Cooperative Group Reorganization
Group Consolidation: no more than 4 adult groupsFormation of a “Network”
Harmonization of processesTrans network collaborationNetwork wide prioritization
ACRIN Annual Meeting 2011
Implications for ACRIN
ACRIN would not be able to compete on its own for membership in the cooperative group network
Opportunity for developing a formal structure for core support of the cooperative group network
ACRIN Annual Meeting 2011
ECOG-ACRIN Alliance
“The groups plan to form an alliance that combines their complementary strengths”
“The new organization will include three areas of research emphasis: early detection and diagnosis of cancer; biomarker-driven Phase II and Phase III therapeutic studies for multiple cancer types and stages; and genetic, molecular and imaging marker research to predict and monitor treatment response.”
ACRIN Annual Meeting 2011
Progress
Name Program Structure Collaborative CCOP Research Base grant
submission Joint trial (s) Developing
Membership model Operational model Governance structure
ACRIN Annual Meeting 2011
Overall Impact on ACRIN
ACRIN Oncology
ACRIN Cardiology
ACRIN Neuro-
Sciences
ECOG
New Group
ACRIN Annual Meeting 2011
ECOG –ACRINCooperative Group, Inc.
BOM
BiostatsDM
Scientific Steering Committee
OPS
TherapeuticsSparano/ACRIN
Biomarker ScienceHamilton/Flaherty/Mankoff
Cancer Control and Outcomes
ECOG ACRIN
DOCEISCLAB SCI
DT
OTHER
PT CENTERED OUTCM/SURVIVWagner/Black
Early DETEC/DX/PREVENTIONKhuri/Schnall
Underserved
SX CER
Outcomes Prev Det/Dx
ACRIN Annual Meeting 2011
Process
Initial Presentation to group chairs: Nov 2010 Meeting with Chairs: Jan, March, April, May 2011 Vetting proposal/progress
IOM/ASCO workshop (March 21, 2011) AACR (April 5th, 2011) ASCO, 2011
Developing FOA Aug 2011: internal NCI review Nov 2011: BSA Concept review July 2012: FOA released Nov 2012: Applications due Feb 2013: Review Roll out new awards in 2014
ACRIN Annual Meeting 2011
Hopes\Challenges for the Alliance:
The ACRIN Perspective
Strengthen cancer biology expertise contributing to imaging trial development
More effective integration with therapeutic development
Better access to trials with novel targeted therapeutics
Better accrual to imaging biomarker studies
Integrative approach to diagnostics
Engagement of the cooperative group structure in studying the entire cancer care path
Maintaining a scientific focus in early detection/diagnostics
Adapting to the membership structure of the cooperative group network
Maintaining the clinical trial infrastructure in the academic and practice community
Continuing to be nimble enough to aggressively pursue opportunity
Hopes Challenges
ACRIN Annual Meeting 2011
Seize the Day!
Opportunity to develop the new model for cooperative group science
Innovative science driven research Multimodality diagnostics Set the imaging agenda