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National Institute for Public Health and the Environment ACROPOLIS Jacob van Klaveren

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ACROPOLIS Jacob van Klaveren. Contents. History and starting point Aims of ACROPOLIS Main overview (WPs) Project organisation. Starting point for ACROPOLIS. An electronic platform for pan-European exposure modelling as created in SAFE FOODs - PowerPoint PPT Presentation

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Page 1: ACROPOLIS Jacob van Klaveren

National Institutefor Public Healthand the Environment

ACROPOLIS

Jacob van Klaveren

Page 2: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 2National Institutefor Public Healthand the Environment

• History and starting point

• Aims of ACROPOLIS

• Main overview (WPs)

• Project organisation

Contents

Page 3: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 3National Institutefor Public Healthand the Environment

Starting point for ACROPOLIS

• An electronic platform for pan-European exposure modelling as created in SAFE FOODs

• Existing models like EuroPOEM, CONSEXPO, MCRA, IPRA

• EFSA opinions on cumulative risk assessment

Page 4: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 4National Institutefor Public Healthand the Environment

Aims of ACROPOLIS

• Improve cumulative exposure and hazard assessment

• Create new models for aggregated exposure assessment

• Setting up new toxicological testing for identifying synergistic effects

• To integrate cumulative and aggregated risk models

• Improve understanding of methodology of different stakeholders

Page 5: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 5National Institutefor Public Healthand the Environment

NLIT

SE

0.0

0.2

0.4

0.0 0.7 1.4 2.2 2.9 3.6-0.7-1.4-2.2-2.9-3.6

UK

MCRA-software

E-platform of databases (food and residue)

CZ

FR

Page 6: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 6National Institutefor Public Healthand the Environment

van der Voet & Slob (2007)

Toxicological BMD modeling

• Critical effect dose

• Number of experiments

• EFSA opinion BMD modeling

Page 7: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 7National Institutefor Public Healthand the Environment

Aggregated exposure assessment

Combine leading models in Europe(MCRA, EUROPOEM, ConsEXPO)

Case studies with two or more different routes of exposure

Validation of the model

Page 8: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 8National Institutefor Public Healthand the Environment

Mixtures and internal does

Page 9: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 9National Institutefor Public Healthand the Environment

Model and software development

Internet compatible model and data

• Test and justify underlying assumptions

• Scientific sound

• Reproducible and transparent (reference manual MCRA openly available)

• Include quantitative uncertainty analyses

• Data in connection with model available for stakeholders (including industry). Not the raw data.

Page 10: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 10National Institutefor Public Healthand the Environment

Risk based on Margin of Exposure

Be aware that safety factors are also modelled!

Page 11: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 11National Institutefor Public Healthand the Environment

Dissemination

• Training

• Stakeholder conferences

• Website and folders

• Scientific paper on stakeholders attitudes towards cumulative and aggregated exposure levels

Page 12: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 12National Institutefor Public Healthand the Environment

Stakeholders

• Industry

• Regulators

• EFSA and risk assessors at national level

• Risk Management

Page 13: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 13National Institutefor Public Healthand the Environment

ACROPOLIS PROJECT STRUCTURE

Page 14: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 14National Institutefor Public Healthand the Environment

External advisory board

EFSA (Luc Mohimont)

DG Sanco (Bas Drukker)

EPA (D. Miller will be asked)

Coordinator

- Further elaboration on case studies

- Overview needs of DG Sanco (risk managers)

- Fine-tune research needs of EFSA

Page 15: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 15National Institutefor Public Healthand the Environment

Scientific Advisory Board

WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof W. Steurbout, dr. D Hamilton), Greenpeace (dr. M. Krauter), Industry (Bayer, BASF, Syngenta)

- To convey relevant issues from a stakeholders perspective

- To bring in relevant expertise (e.g. from USA)

- Emerging issues in pesticide risk assessment

- Implementation of project outcomes at EU level

Page 16: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 16National Institutefor Public Healthand the Environment

Deliverables and milestones

A deliverable is a result that has to be produced

(e.g. a paper, a model, or any other result)

A milestone is something that you have to achieve before you can continue

All have to be done in time and as promised

Page 17: ACROPOLIS Jacob van Klaveren

Jacob van Klaveren ACROPOLIS kick-off meeting 17National Institutefor Public Healthand the Environment

Project Management Team

• A representative of each beneficiary

• Stop-go decisions

• Contingency plan (coordinator)

• Financial issues as far as they deviate from proposal

• Gender issues

Page 18: ACROPOLIS Jacob van Klaveren

National Institutefor Public Healthand the Environment

MCRA model : https://mcra.rikilt.wur.nl/ EFSA opinion : EFSA website  RIKILT report

Thanks for your attention!

[email protected]