actinomycetes ecology - ksufac.ksu.edu.sa/sites/default/files/lec_10_actinomycetes_nocardia.pdf ·...
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Actinomycetes Ecology
• Predominantly soil bacteria
• Give soil the “earthy” smell
Human host:
• Commensals in the Mouth
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Actinomycetes morphology
• Gram-positive bacilli
• Have filamentous growth
• Facultative anaerobes
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• ¾ of human cases are caused by Actinomyces israelii
• Some are aerobic and others are anaerobic
• All are slow growing
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Clinical significance:
• Actinomycosis
• Mycetoma
• Cervicofacial infection
• Thoracic actinomycosis
• Abdominal actinomycosis
• Pelvic actinomycosis
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• Specimens:
should be obtained directly from lesions by open
biopsy, needle aspiration
Sputum
Sulfur granules
• Culture: Anaerobic
Growth is slow
enriched media
Metronidazole
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Treatment:
– Penicillin V
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• rod- shaped bacteria
• weakly acid- fast beaded branching filaments
• A total of 85 species
• Some species are responsible for nocardiosis
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Ecology and Epidemiology
– Environmental saprophyte
– Tropical and subtropical regions
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Risk Factors
• Immunocompromised
• Organ transplantation
• Steroid use
• Diabetes
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Virulence Factors
– Inhibit Phagosome-lysosome fusion
– Survive in macrophages for days
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Clinical presentation
– Invasive pulmonary infection
– Disseminated infection
– Brain abscess
– Cellulitis
– Cutaneous nocardiosis
– Mycetoma
– Madura foot
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• Sulfur granules
• Usually weak acid fast
• Culture (48 hrs – 4 wks)
• Strictly aerobic
• Culture at 37°C, 45°C
• Sabouraud’s dextrose agar with antibiotic or
LJ medium, brain-heart infusion agar
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Treatment
– Long-term antibiotic therapy (usually with
sulfamethoxazole with trimethoprim)
– Chronic suppressive therapy