acupuncture and opioids€¦ · report to outline state of science regarding prescription opioid...
TRANSCRIPT
ACUPUNCTURE AND
OPIOIDSJason Go, R.Ac, Dipl. Ac. (NCCAOM), MSAOM
Blue Dragon Acupuncture
JASON GO
Owner/Acupuncturist at Blue Dragon Acupuncture
1201 Stone Street
Suite 2 (Michigan Rheumatology Office)
312-622-3659
Facebook page: Blue Dragon Acupuncture Clinic
MSAOM and BS in Nutrition from Midwest College Of Oriental Medicine, Chicago
BS in Biopsychology and Cognitive Science from University of Michigan, Ann Arbor
PRESENTATION OUTLINE
What is Acupuncture?
Acupuncture Pain
Mechanisms of Action
Acupuncture and Opioid Use
Acupuncture is Safe
Acupuncture is Cost Effective
WHAT IS TRADITIONAL CHINESE
MEDICINE (TCM)?
4 major principles:
1. Your body is an integrated whole
2. You are completely connected to nature
3. You were born with a natural self-healing ability
4. Prevention is the best cure
ACUPUNCTURE
“Acus”= Needle in Latin
Def’n: “The insertion of extremely thin
needles through the skin at strategic
points in the body.” – Mayo Clinic
ACUPUNCTURE AND
OPIOIDSHow can acupuncture impact the opioid
epidemic?
ACUPUNCTURE AND PAIN
ACUPUNCTURE BEING RECOMMENDED AS
FIRST-LINE NON-PHARMACOLOGICAL
THERAPY
FDA- May 2017-”Blueprint for Prescriber Education for Extended-Release and Long-Acting Opioids”
Doctors become informed about non-pharmocological options
National Academies of Sciences, Engineering and Medicine
Report to outline state of science regarding prescription opioid abuse and misuse
Recommends more public education, reimbursement models and support for non-drug approaches
Effective Jan1, 2018: Joint Commmision
Mandated hospitals provide non-pharmacological pain treatment modalities
ACUPUNCTURE IN THE ER
Acupuncture in Emergency rooms
St Francis Regional Medical Center and Abbott Northwestern
Study of acupuncture vs morphine: 300 patients (150 in each
group)
Acupuncture: more effective, faster and better tolerated
Success rate: 92% in acu vs 78% in morphine
Resolution time: 16+/- 8 minutes vs 28 +/- 14 minutes
Adverse effects: overall 89, 85 in morphine, 4 in acu
ACUPUNCTURE AND PAIN
STUDIES
ACUTE PAIN
Xiang, A., Cheng, K., Xu, P., Liu, S.
Systematic Review of 13 trials
Acupuncture was more effective than sham acupuncture and
injection of pain killers
CHRONIC PAIN
2007: Weidenhammer W., Strong, A., Linde, K., Hoppe, A.,
Melchart, D.
454,920 patients- Headache, low back pain or osteoarthritis
Acupuncture had marked or moderate effectiveness
76% of cases
8727 physicians
CHRONIC PAIN (CONT)
2016: American Specialty Health Incorporated Health Services
Department
2 year retroactive study
Over 89,000 patients
93%- acupuncturist was successful in treating musculoskeletal
pain
CHRONIC PAIN (CONT)
2012: Vickers, AJ, Cronin, AM, Maschino, AC, Lewith, G, MacPherson, H, Foster, NE, et.al.
Meta-analysis of 17,922 patients
“Acupuncture is effective for treatment of chronic pain and is therefore a reasonable referral option. Significant differences between true and sham acupuncture indicate that acupuncture is more than a placebo.”
2016: MacPherson, H, Verstocke, EA, Foster, NE, Lewith, G, Linde, K and Sherman, KJ
Follow up: benefits persisted 12 months after end of treatment
EFFECTIVENESS AND EFFICACY OF
ACUPUNCTURE
According to Fan, et. Al. (2017)…Strongest evidence for
1. Back pain
2. Neck pain
3. Shoulder pain
4. Chronic headache
5. Osteoarthritis
EFFECTIVENESS AND EFFICACY (CONT)
ACUPUNCTURE EVIDENCE PROJECT (MAR
13-SEP16)
Evidence of positive effect:
Allergic rhinitis (perennial and seasonal)
Chemotherapy induced N/V
Chronic LBP
HA (tension and chronic)
Knee osteoarthritis
Migraine prophylaxis
Post-op N/V
Post-op pain
EFFECTIVENESS AND EFFICACY (CONT)
ACUPUNCTURE EVIDENCE PROJECT (MAR
13-SEP16)
Evidence of potential positive effect:
Acute LBP
Acute stroke
Ambulatory anesthesia
Anxiety
Aromatase inhibitor induced arthralgia
Ashtma
Back/Pelvic pain during pregnancy
Cancer pain
Cancer related fatigue
Constipation
Craniotomy anesthesia
Depression
Dry eye
Hypertension
Insomnia
IBS
Labor pain
EFFECTIVENESS AND EFFICACY (CONT)
ACUPUNCTURE EVIDENCE PROJECT (MAR
13-SEP16)
Evidence for potential positive effect (cont)
Lateral elbow pain
Menopausal hot flashes
Modulating sensory perception thresholds
Neck pain
Obesity
Peri- and post-menopausal
insomnia
Plantar heel pain
Post-stroke insomnia
Post-stroke shoulder pain
Post-stroke spasticity
PTSD
Prostatitis pain and pelvic pain syndrome
EFFECTIVENESS AND EFFICACY (CONT)
ACUPUNCTURE EVIDENCE PROJECT (MAR
13-SEP16)
Evidence of potential positive
effect (cont)
Post colorectal cancer
resection
Restless leg syndrome
Schizophrenia
Sciatica
Shoulder impingement
syndrome
Shoulder pain
Smoking cessation
Stroke rehab
TMJ
EFFECTIVENESS/EFFICACY (CONT)
Statistics based on systemic reviews and meta-analysis
1. Knee osteoarthritis
2. Sciatica
3. Lateral elbow pain
4. Plantar heel pain
5. Post surgical pain
OSTEOARTHRITIS OF KNEE
2013: Corbett, MS, Rice, SJC, Madurasinghe V, et.al.
Meta analysis comparing physical treatments
Acupuncture had the largest effect
Over exercise, sham acupuncture, weight loss
TOTAL KNEE ARTHROPLASTY
2018: Chen D, Sheng, D, Xu, JL, Zhang, YY, Lin TY
Electroaccupunture
Visual analogue scale (VAS) significantly lower in EA
No significant differences in ROM
Frequency of pushing drugs (morphine, ropivacaine, droperidol
and sodium chloride) was lower in EA group (5% vs 15%)
“Electroacupuncture combined with pain relieving drugs into an
integrated treatment protocol is more effective than pain-
relieving drugs as a monotherapy.”
SHOULDER IMPINGEMENT SYNDROME
2015: Dong, W., Goost, H., Lin X-B, et.al.
Compared treatments in addition to exercise
Acupuncture was most effective out of 17 treatments
Outperformed- steroid injections, NSAIDs, and ultrasound
SCIATICA
2016: Lewis, R
Examined 20 treatments for sciatica
Acupuncture was 2nd most effective
After biological agents
Outperformed- manipulation, epidurals, disc surgery, opioids,
exercise, radiofrequency denervation
ACUPUNCTURE
MECHANISM OF ACTION
SENSORY NERVE PATHWAYS
Acupuncture affects specialized nerve fibers (Aδ, Aβ, and C)
Also affects descending nerve pathways
DIRECT EFFECTS ON CNS
Spinal reflex- acupuncture stimulates muscle relaxation changes
in visceral organs
Brain
Change functional connectivity
Decreased activity in limbic structures
Associated with stress and illness
Improve regulation of hypothalamus pituitary adrenal axis
Modulate parasympathetic activity
PURINERGIC SIGNALING
Acupuncture elicits release of adenosine and ATP
Helps nerve transmission
Purine levels as background signal for healthy and damaged
tissue
2018: Huang, M, Wang, X, Xing, B, et.al.
Mice bred to not be able to bind to adenosine were found to
have no pain relief or any biological markers associated with
relief
BIOMOLECULES- SUBSTANCE P
Transmits pain information in to CNS
DeFelipe C, Herrero, JF, O’Brien, JA, Palmer, JA, Doyle CA, et.al.
(!998)
Donkin, JJ, Turner, RJ, Hassan, I, Vink, R (2007)
Electroacupuncture and Moxibustion
Down-regulates expression of Substance P in IBS patients
Donkin, JJ, Turner, RJ, Hassan, I, Vink, R (2007)
BIOMOLECULES- NITRIC OXIDE (NO)
Tsuchiya, M., Sato, E.,Inoue, M., Asada, A. (2007)
Local release of Nitric Oxide
Increase local circulation
ENDOGENOUS OPIOIDS
Electroacupuncture- increase in plasma or CSF
Activates endogenous opioid system and non opioid receptors
Part of response is antagonized by naloxone
ENDOGENOUS OPIOIDS (CONT)
Han, JS (2003)
Low-frequency (2Hz) “induces activation of mu- and delta-opioid
receptors”
Releases- enkephalin, beta-endorphins and endomorph
Supraspinal CNS regions
High frequency (100Hz)- dynorphin actions on kappa opioid
receptors in spinal cord
ENDOGENOUS OPIOIDS (CONT)
Harris, et al. (2009)
Acupuncture- short term increases in MOR binding potential
Long term increases in pain and sensory processing regions in the
brain
Absent in sham acupuncture
ACUPUNCTURE’S ANALGESIC
MECHANISMS
In animal models
Acu and electroacu- effective in alleviation of inflammatory, neuropathic, cancer-related and visceral pain
Triggers release of ATP and adenosine
Ascending neural pathways involving A-Beta, A-delta and C-sensory fibers
Mesolimbic analgesic loop in brain and brainstem
Descending pathway mechanisms
Dopamine, cytokine, glutamate, nitric oxide, GABA effects
Opioid neuropeptides- enkephalins, endorphins, dynorphins, endomorphins, nociception
Non-opioid neuropeptides- substance P, Vasoactive intestinal peptide, calcitonin gene-related peptide
ACUPUNCTURE AND MALADAPTIVE
NEUROPLASTICITY
Maladaptive neuroplasticity is challenge in pain management
Can be associated with sever chronic pain that is resistant to
treatment
Acupuncture may relieve symptoms
Evidence shows it may be able to reverse neuroplastic changes
in spine and somatosensory cortex
CARPAL TUNNEL AND
SOMATOSENSORY CORTEX
Maeda Y, Kim, H, Kettner, N, Kim, J, Cina, S, Malatesta, C, Gerber,
J, McManus, C, Ong-Sutherland, R, Mezzacappa, P, Libby, A,
Mawla, I, Morse, L, Kaptchuk, T, Audette, J, Napadow, V (2017)
“…acupuncture at local versus distal sites may improve median nerve function at the wrist by somatotopically distinct
neuroplasticity in the primary somatosensory cortex following
therapy. Our study further suggests that improvements in primary
somatosensory cortex somatotopy can predict long-term clinical
outcomes for carpal tunnel syndrome.
ADJUNCTIVE ACUPUNCTURE AND
OPIOID USE
Lin, JG, et al (2002) and Wang, B. et al (1997)
Decrease of more than 60% for post surgery pain
Xheng, Z., et al. (2008)
39% reduction in opioid like medication non-malignant pain
After acupuncture-
Lasted up to 8 weeks after treatments stopped
Tedesco, D. (2017
Reduction with the use of electroacupuncture
Acupuncture delayed opioid use
ADJUNCTIVE ACUPUNCTURE AND
OPIOID USE (CONT)
IN USAF medical center
Opioid prescriptions decreased by 45%
Muscle relaxants by 34%
NSAIDs by 42%
Benzodiazepines by 14%
Quality of life measurements showed statistically significant improvements
In elderly, falls from mental impairment
New Zealand Medical Journal: medication related harms-common and burdensome
ACUPUNCTURE AND OPIOID ABUSE
DISORDER
Chen, Z, Wang, Y, Wang R, Xie, J, Ren, Y (2018)
Acupuncture could be effective in treating OUD
Electroacupuncture
Alleviate symptoms of craving and depression
Can improve insomnia and anxiety
ACUPUNCTURE USE IN OPIATE
DEPENDENCE AND REHAB
Wen, et al. (1973)- Ear acupuncture alleviated opioid withdrawal
S/S
NADA- National Acupuncture Detoxification Association
established in 1985
Addresses…
acute and prolonged withdrawal symptoms
Stress and anxiety
Relapse
ACUPUNCTURE USE IN OPIATE
DEPENDENCE AND REHAB
Hu, et. al. (2009)- EA affects dopamine neurons
Improved harmful effects of opioid medication
Lee, et al.(2012)- EA can be used to decrease drug seeking
behavior in rats
We, et al. (1978)- Acu decreased biochemical stress markers
Chan, et al. (2014)
Decreased amount of morphine in treatment
Improved sleep
ACUPUNCTURE USE IN OPIATE
DEPENDENCE AND REHAB (CONT)
Meta analysis in 2012
“ the majority of studies agreed on the efficacy of acupuncture as
a strategy for the treatment of ‘opiate addiction’”
“neurochemical and behavioral evidence have shown that
acupuncture helps reduce the effects of positive and negative reinforcement involved in opiate addiction by modulating
mesolimbic dopamine neurons. Moreover, several brain
neurotransmitter systems involving opioids and GABA have been
implicated in the modulation of dopamine release by
acupuncture.”
SAFETY
Trial regarding chronic pain management: 454,920 patients with HA, LBP and/or osteoarthritis
Minor adverse reactions: needling pain, hematoma, bleeding
7.9%
Serious adverse reactions: pneumothorax, acute hyper- or hypo-tensive reactions, erysipelas, asthma, aggravation of suicidal thoughts
.003%n (13 patients)
Feasibility study
Feasible, safe and acceptable in an ICU setting
Systematic review
Performed by trained practitioners using CNT
Literature- acupuncture with cancer patients with low risk
COST-EFFECTIVENESS
Systematic review of 8 cost-utility and cost-effectiveness studies
Cost per quality adjusted life year gained below threshold for “willingness to pay”
LBP, neck pain, dysmenorrhea, migraine, HA and osteoarthritis
Cost-effectiveness analysis of osteoarthritis of knee
Acupuncture was most cost effective option
Full insurance coverage for acupuncture…
Increase premium from $.38 to $.76
Save $35,480 for migraine, $32,000 for angina pectoris, $9,000 severe osteoarthritis and $4,246 for carpal tunnel
ACUPUNCTURE EVIDENCE PROJECT-
CONDITIONS WITH DEMONSTRATED COST-
EFFECTIVENESS
Allergic rhinitis
LBP
Ambulatory anashthesia
Migraine
Chronic pain
Depression
Osteoarthritis
Dysmennorhea
Post op N/V
Headache
MARKUS MUNGER, PT
CRED. MDT
Owner Munger Physical Therapy 2008
Multiple lectures on Spine pain, athletic injury and Rehab, Fall/ Balance Rehab, and benefit of LSVT with PD
Physical Therapist for 30 years
OBJECTIVES
The science behind pain
Pain vs Function
Pain vs performance
Current research
Mechanical assessment: reproduce vs reduce
Acute/ Sub-acute/ Chronic
Benefits of Physical Therapy
Benefits of exercise prescription
IS PAIN AN
INJURY?
IS PAIN AN INJURY? REALITY
No Pain No Tissue Injury
No Pain Tissue Injury
Pain No Tissue Injury
Pain Tissue Injury
MISCONCEPTIONS Pain is bad
Pain indicates something damaged or harmed
Pain needs to be abolished before engaging in
normal activity and movement
Passive treatment is the answer
Pain will increase with all movement
Work is potentially harmful
ACUTE AND SUB ACUTE
PAIN
CHRONIC
PAIN
Serves no biologic purpose
No recognizable end point
Disease state that can persist for months or years
CHRONIC PAIN
CREATES
DEPENDENCE ON
MEDICATIONS
Greater than 12
weeks.
HOW DO WE
MANAGE
PAIN
YELLOW FLAGS OF PATIENT MANAGEMENT
Attitudes Belief Compensations
Dx EmotionsFamily (and
Friends)
NUMERICAL PAIN RATING SCALE
(NPRS)
1. 0-2 Safe
2. 2-5 Acceptable
3. 5-10 High risk
Pain is allowed to reach a 5
Pain after completion of activity is
allowed to reach a 5
Pain in morning should not exceed a 5
Pain and stiffness is not allowed to
increase from week to week
Adapted from Silbernagel & Crosley, JOSPT, 2015
THE WILK CLASSIFICATION SYSTEM
___Stage Definition Red Flag
1 Pain upon Exertion Pain that alters Mechanics
2 Pain @ Rest Pain that prevent rest
3 Pain with ADLs Avoidance of ADLs
4 Pain Managed with Meds Being in Stage 4
5 Crippling pain Being in Stage 5
HOW CAN PHYSICAL
THERAPY HELP?
THE RESEARCH
PT and Yoga
Chronic back pain
OA of knees
Before and after surgery
Arthritis
OPIOIDS AND
Low back pain
After surgery
Arthritis
PHYSICAL THERAPY
Collaboration with:
Patients
Families
Professionals
Payers
WHEN TO SEND
Mechanical pain: or changes with position or movement
Acute/ Chronic injuries
Pain that does not resolve with OTC medications
When personalized care is needed to meet your patient's needs
To empower patients to be active participants in their care
To reduce opioid dependence
Conservative, non-surgical care
Inability to return to work or sport
PHYSICAL
THERAPY:
A SOLUTION
Evaluation
Proper exercise prescription
based on patients' level
Assessing patient's motivation to
get better
Education of pain and the
process
MECHANICAL ASSESSMENT
Does pain change with movement
Does pain change with change in position
Peripheralized vs Centralized
Does pain return to baseline or better
RED YELLOW GREEN
EXERCISE
PRESCRIPTION
Develop/ Administer/ Modify/ Progress
Poor conditioning/ impaired strength/
Musculoskeletal imbalance/
deficiencies
Individuals that exercise regularly will
experience less pain
MUSCLE MASS
NATIONAL GUIDELINES FOR PHYSICAL
ACTIVITY
THESE ARE THE MINIMUM GUIDELINES
Children / Adolescents: Ages: 6-17
60+ minutes daily
Moderate / vigorous aerobic activities
Muscle strengthening activities
Bone strengthening activities
Adults: Ages: 18-64
Weekly
Aerobic activities (10+ minute bouts)
150 minutes moderate intensity
75 minutes vigorous intensity
An equivalent combo of both
Muscle strengthening activities 2+ days
“THE MAIN IDEA BEHIND THE GUIDELINES IS THAT
REGULAR PHYSICAL ACTIVITY OVER MONTHS
AND YEARS CAN PRODUCE LONG-TERM
HEALTH BENEFITS. ”
Published by the US Dept, of Health and
Human Services (DHHS) in 2008
MANUAL THERAPY
Hands on manipulation of joints/
tissue
Modulate pain, reduce swelling,
reduce inflammation
Improve mobility
STRESS MANAGEMENT
Mindfulness
Relaxation
Visualization
Biofeedback
SLEEP DISTURBANCE DUE TO PAIN
Sleeping postures
Pre sleep stretch
Deep breathing/ Relaxation
PAIN NEUROSCIENCE
EDUCATION
SUMMARYWilk
classification 4Pain does not stay below a 5
Compensation with
movement
Patient says so: A B C
FUNCTION ECCENTRIC VS
PAIN ECCENTRIC
REFERENCES
1. Beyond Opioids: How Physical Therapy Can Transform Pain Management and improve Health: American Physical Therapy Association 2. Wroblewski AP, Amati F, Smiley MA, et al. Chronic Exercise Preserves Lean Muscle Mass in Masters Athletes. The Physician and Sports Medicine, 2015;39:3 (172-178) doi: io.38io/psm.2oi
1.09.19333. IASP Taxonomy. Webpage. International Association for the Study of Pain. Last updated December 14, 2017. https://www.iasp-pain.org/Taxonomy#Pain. Accessed April 2, 2018.4. Holth HS, Werpen HKB, Zwart J-A, Hagen K. Physical inactivity is associated with chronic musculoskeletal complaints 11 years later: results from the Nord-Trøndelag Health Study. BMC
Musculoskelet Disord. 2008;9:159. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606680/. Accessed April 2, 2018.5. Fernández-de-Las Peñas C, Ortega-Santiago R, de la Llave-Rincón AI, et al. Manual Physical therapy versus surgery for carpal tunnel syndrome: a randomized parallel-group trial. J Pain.
2015;16(11):1087-94. https://www.ncbi.nlm.nih.gov/pubmed/26281946. Accessed April 2, 2018.6. Delitto A, George SZ, Van Dillen L, et al. Clinical practice guidelines linked to the International Classification of Functioning, Disability, and Health from the Orthopaedic Section of the American
Physical Therapy Association. J Ortho Sports Phys Ther. 2012;42(4):A1-57. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893951/. Accessed April 2, 2018.7. Okifuji A, Hare BD. The association between chronic pain and obesity. J Pain Res. 2015;8:399-408. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508090/. Accessed April 2, 2018.8. Finan PH, et al. The association of sleep and pain: an update and a path forward. J Pain. 2013;14(12):1539-15529. Hayden JA, van TUlder MW, Malmivaara A, Koes BW. Exercise therapy for treatment of non-specific low back pain. Cochrane Database Syst Rev. 2005;Jul 20(3):CD000335.
https://www.ncbi.nlm.nih.gov/pubmed/16034851. Accessed April 2, 2018.10. Mover R, Ikert K, Long K, Marsh J. The value of preoperative exercise and education for patients undergoing total hip and knee arthroplasty: a systematic review and meta-analysis. JBJS Rev.
2017;5(12):e2. https://www.ncbi.nlm.nih.gov/pubmed/29232265. Accessed April 2, 2018.11. Fransen M, McConnell S, Hernandez-Molina G, Reichenbach S. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2014;22(4):CD007912.
https://www.ncbi.nlm.nih.gov/pubmed/24756895. Accessed April 2, 2018.12. Messier SP, Mihalko SL, Legault C, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee
osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310(12):1263-73. https://www.ncbi.nlm.nih.gov/pubmed/24065013/. Accessed April 2, 2018.13. Deyo RA, Von Korff M, Duhrkoop D. Opioids for low back pain BMJ. 2015;350:g6380. http://www.bmj.com/content/350/bmj.g6380. Accessed April 2, 2018.14. Brummett CM, Waljee JF, Goesling J, et al. New persistent opioid use after minor and major surgical procedures in US adults. JAMA Surg. 2017;152(6):e170504.
https://jamanetwork.com/journals/jamasurgery/articleabstract/2618383?redirect=true. Accessed April 2, 2018.15. Ivers N, Dhalla IA, Allan GM. Opioids for osteoarthritis pain: benefits and risks. Can Fam Physician. 2012;58(12):e708. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520677/. Accessed April 4,
2018.
FAILURE OF OTHER
MODALITIES:
MANAGING PAIN
WITH MEDICATION
Dr Nick Reina
EVALUATE
HISTORY AND PHYSICAL
DOCUMENTATION/ TEST RESULTS
SCREENING ORT PHQ-9
DOSING
Morphine mg Equivalent
Codeine 6:1
Hydrocodone 1:1
Oxycodone 1:1.5
Fentanyl 2.4ug:1
Oxymorphone 1:3
Hydromorphone 1:4
FOLLOW UP /
SURVEILLANCE
Prescription Profiling / MAPS
Drug Testing
Pill Counts
Benefit tools
Oswerky (function)
Quality of life Surveys
Meaningful use/ Rechecks every 3 months
QUESTIONS?