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ADAPTATION: THE BODY’S RESPONSE TO TRAUMA Centre for Trauma Sciences Queen Mary University of London www.c4ts.qmul.ac.uk Royal London Major Trauma Centre Barts Health NHS Trust KARIM BROHI, FRCS FRCA Professor of Trauma Sciences, QMUL

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Evolution and inflammation. Karim Brohi critiques our approach to sepsis and how we should consider more judicious, multi-directional approach.

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Page 1: Adaptation: The Body’s Response to Trauma by Brohi

ADAPTATION: THE BODY’SRESPONSE TO TRAUMA

Centre for Trauma SciencesQueen Mary University of Londonwww.c4ts.qmul.ac.uk

Royal London Major Trauma CentreBarts Health NHS Trust

KARIM BROHI, FRCS FRCAProfessor of Trauma Sciences, QMUL

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EXSANGUINATION

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CATASTROPHIC ORGAN DYSFUNCTION

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INFECTION

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PERSISTENT INFLAMMATION CATABOLISM SYNDROME

(PICS)

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SURVIVAL PATHWAYS

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NFκB

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NFκB

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NFκB

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STOP THE DRIVERS OF INFLAMMATION

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DON’T FIGHTEVOLUTION

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