ADVANCE Adult Large/Giant Breed is a complete & balanced diet specifically formulated

for large and giant breed dogs, 25kg or over

Key benefits of ADVANCE Adult Large/Giant Breed:

1. Contains Green Lipped Mussel powder for improved Joint Health

2. Kibble size and shape reduces the risk of gastric dilation (bloat)

3. Formulated to help maintain Heart Muscle function

What is Cartilage and what is its role in Joint Health?

Cartilage is dense connective tissue that lines the surface ofjoints. Its two main functions are:

1. It provides a slippery coating, which cushions the bone and aids in reducing friction when the bones slide over each other

2. It acts as a shock absorber CARTILAGE

SYNOVIAL FLUID

BONE

HEALTHY JOINT

WHY IS JOINT

HEALTH SO IMPORTANT

FORLARGE/GIANT BREED DOGS?

Osteoarthritis

When cartilage becomes eroded and exposed bones start to rub against each other, it causes inflammation which is known as Osteoarthritis.

This leads to swelling of the joint cavity, which results in reduced movementand pain.

An important thing to remember is that Osteoarthritis is not only a condition of older animals.

• Some breeds are predisposed to conditions that can lead to arthritis

• High activity levels can lead to premature wear and tear of the joint cartilage

• Large breeds and over weight dogs put more stress on their joints due to their weight

Product Feature: Stabilised Green Lipped Mussel Powder

The unique benefit of the inclusion of Green Lipped Mussel Powder in ADVANCE is that it’s not only a rich source of glucosamine.

It’s a nourishing cocktail of nutrients that work for total Joint Health, including :

Glucosamine

Chondroitin sulphate

Omega 3 fatty acids (ETA, EPA, DHA)

Lyprinol

Vitamins E & C

Amino acids (glutamine, methionine)

Minerals (Zinc, Copper & Manganese)

The inclusion of Green Lipped Mussel Powder in ADVANCE Adult Large/Giant Breed can help to:

• reduce pain and inflammation in the joint

• prevent the incidence of joint degradation

• further limit any existing degeneration of cartilage

• support the regeneration of damaged joint cartilage and synovial fluid

And the benefit….

Green Lipped Mussel Facts:

The Green Lipped Mussel Powder used in ADVANCE has been “stabilised”

When GLM is added to pet food, the high temperatures used in themanufacturing process can diminish the therapeutic properties of the GLMin the end product.

Mars Petcare has put a patent on thisprocess of stabilising GLM powder, making it exclusive to ADVANCE.

So, although there may be other products with joint claims on the market, ADVANCE can proudly guarantee that the ingredients we’ve put in our products for joint health will be present when the food isconsumed and not destroyed during the complex manufacturing process.

GASTRIC DILATION VOLVULUS is also known as gastric torsion or bloat.

It is a potentially fatal condition of deep-chested, large breed dogs.

Due to a number of reasons, the stomach fills up with gases. In many cases the stomach can also twist, which further complicates the situation.

The twisting or “volvulus” of the stomach prevents the gases from escaping and also cuts off the blood supply. If left untreateda dog can die within 6–12 hours.

Some of the causes of Gastric Dilation Volvulus include:

• breed disposition• rapidly gulping down food• eating too much in one sitting• gulping down too much water after eating• exercising straight after eating

The kibble in ADVANCE Adult Large/Giant Breed has been specifically formulated to reduce the incidence of gastric dilation.

The size and shape of the kibble slows down the ingestion rate by encouraging the dog to chewrather than gulp down food.

The feeding guide also states that the recommended daily intakeshould be divided into at least two meals.

These two factors together help in reducing the occurrence of bloat.

Product Feature and Benefit:

ADVANCE Adult Large/Giant Breed Helping to maintain healthy HEART FUNCTION

Cardiac disease is estimated to be the third most common cause of death in dogs and cats. Reports suggest that over 450,000 Australian dogs have some form of cardiac disease. That is 1 in every 8 dogs.

Large and giant breeds, such as Great Danes, Dobermans and Boxers, are predisposed to cardiac diseases such as Canine Dilated Cardiomyopathy (DCM) Canine Dilated Cardiomyopathy causes the chambers of the heart to dilate, and the papillary muscles to flatten and become atrophic. The papillary muscles are responsible for controlling the opening and closing of the valves in the heart.

This leads to a reduced ability of the heart to contract efficiently which can lead to heart failure.

Papillarymuscle

ADVANCE Adult Large/Giant Breed has been designed to support optimal Heart Health in the following three ways:

1. Increased inclusion level of Taurine 2. Increased inclusion level of Arginine 3. Increased inclusion level of Vitamin E

Cocktail Component

Target Level in Finished Product per 1000k/ cals

Taurine min 500mgArginine min 5gVitamin E min 200 IU

1. Increased levels of TAURINE – there is a well known link between taurine deficiency and Dilated Cardiomyopathy in cats.

The reason why taurine is essential in healthy heart function has not been fully proven however there are many commonly accepted theories.

Most dogs have an adequate blood taurine level, however studies in dogs have shown that dogs that suffer from Dilated Cardiomyopathy have also had low blood taurine.

2. Increased levels of ARGININE – arginine is an amino acid that plays a key role in regulating blood circulation and hence in maintaining vascular health.

Therefore its inclusion in this ADVANCE diet may help to improve optimal circulation and heart function (Hackett 2002)

3. Increased levels of VITAMIN E – Vitamin E playsa major role in the body as an antioxidant. The positive impact of Vitamin E on cardiac health is dueto its antioxidant properties (Hackett 2002)

It is such a naturally strong antioxidant due to its chemical structure.

This chemical composition makes it highly effective in preventing free radical damage(oxidative damage).

Free radical action and insufficient antioxidantprotection have been implicated in the developmentof many cardiac diseases.

Vitamin E Study:

A 1999 study by Freeman et al, showed that dogs that suffered from Dilated Cardiomyopathy had a higher level of oxidative damage compared to a control group of dogs.

It was also noted that the severity of the DCM in affected dogs had a negativecorrelation to the level of Vitamin E in the dogs’ plasma . Therefore, the moresevere the DCM, the lower the level of Vitamin E.

Asides from the antioxidant actionof Vitamin E, it has also been shownto promote cardiac health in a number of other ways including reducingplatelet adhesion and aggregation(Hackett 2002).

CORRELATION BETWEEN THE SEVERITY OF DCM AND THE LEVEL OF VITAMIN E (Freeman et al 1999)

0

50

100

150

200

250

I II III IV

CLASS

% OF C

ONTR

OL GR

OUP

MEAN

VITAMIN C

MALONDIALDEHYDE

GLUTATHIONEPEROXIDASE

VITAMIN E

So to clarify….What exactly are free radicals?

A stable oxygen molecule is one which has electrons in pairs in its outer shell.

Free radicals are atoms or molecules in the body that don’t have electrons in pairs, therefore making them highly unstable.

In trying to become stable, they steal electrons away from other molecules and by doing so causes cell death, tissue damage and more free radicals. This process of “electron stealing” is known as oxidation.

Oxidation has been linked to cardiac disease, cancers, arthritis and much more

Antioxidants act to stabilise and neutralise these free radicals and therefore reduce damage to cells in the body.

Electrons In pairs

Other benefits of ADVANCE Adult Large/Giant Breed include :

Dental : kibble size, shape & texture has been scientifically proven to reduce plaque and tartar accumulation

Nutrifibre : for fewer, firmer stools

Skin & Coat : for improved coat health, lustre & softness

Antioxidants : increases the body’s natural defences

Urinary Tract Support : lowers the risk of Urinary Tract Infection

And not to forget…its Made in Australia