advanced cervical cancer and renal failure
TRANSCRIPT
Where is the connection?
Renal failure and Cervical cancer
Clinical ScenarioMrs X 50 YrsPresented with post coital bleeding and vaginal
dischargeFound to have stage 2a cervical carcinoma (invasion
of upper 2/3 of vagina but not parametrium)2 years ago had a radical abdominal hysterectomy
(Wertheim’s hysterectomy) involving pelvic LN clearance, hysterectomy, removal of the parametrium and upper 1/3 of the vagina and oophorectomy.
LN involvement was found hence chemoradiotherapy commenced
Presentation2years after finishing her chemo
radiotherapy Mrs X has now been referred to you, the oncologist, by her GP with the following symptoms:TirednessAnorexia and nauseaOliguriaSome mild rectal bleeding
What will you do?
Course of ActionHistory and examination
History: Full history Details of her treatment for cervical cancer and
status after completing her treatment.Any symptoms of recurrence or metastatic disease –
bowel, lung etc.Examination:
Vaginal examinationPR examinationAbdominal examination
Initial InvestigationsBloods:
FBC, U+E, LFT, TFT, CRPCT abdomen and pelvisCxR
ResultsFBC: Mild normochromic normocytic
anaemiaU+E: Raised creatinine, urea and
potassiumLFT, TFT, CRP normalCT or MRI pelvis: Pelvic mass appearing to
compress both uretersCxR: normal
ImpressionInvestigations suggest post renal acute renal
failure secondary to ureteric obstruction from a likely recurrence of cervical cancer.
Further investigations to consider:Renal ultrasound to look for any other cause of
ARF, determine kidney size and look for hydronephrosis
Urine and plasma sodium, creatinine and osmolarity to rule out pre renal failure
Intravenous urogram (IVU) to confirm obstructionPET scan to look for metastatic disease
ManagementCurative or palliative depending upon stage
and prognosisTumour:
Surgical resectionChemo and/or radiotherapy
Renal failureRelieve obstruction either by treating the
tumour or insert a ureteric stentNephrostomyUrinary diversion (uretroenteric anastamosis)Depending on severity of ARF, manage
hyperkalaemia. Consider dialysis
JJ stent Nephrostomy
New treatmentsDouble J stents often fail in malignant
ureteric obstruction due to lumen obstruction from clots and tumour which enter through the side holes of the stent
A new double lumen stent has been developed which may be superior
Other approaches are being developed such as self expanding stents and drug impregnated stents
PrognosisTumour will be least stage 3 (causing
ureteric obstruction). This is a poor prognostic sign.
5 year survival for stage 3-4 tumours is 10-30%
ReferencesObstetrics and Gynaecology 2nd ed.
Lawrence Impey.Yachia D. Recent advances in ureteral
stents. Curr Opin Urol 2008; 18(2):241-246.