advances in therapy of solid tumors by using different radioisotopes prof. nossrat firusian,...
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Advances in therapy of solid tumors by using different radioisotopes
Prof. Nossrat Firusian,
Recklinghausen, Germany
Different radiations and potential activity of penetration
Energy - Radiation - Radiation
1 Mev 0,0005 mm 4,3 mm
5 Mev 0,014 mm 25 mm
10 Mev 0,105 mm 55 mm
50 Mev 17 mm 190 mm
Penetration of - and - radiation in water
Most important radioisotopes for therapy of malignant diseases
P32 (Natriumphosphat) pure -Emission 14 d
P32 Colloid pure -Emission 14 d
(Chromphosphat)
90 Colloid pure -Emission 60 h
Sr89 (Chlorid) pure -Emission 51 d
Jod 131 + -Emission 8 d
Important conditions for intralesional therapy by colloidal radioisotopes
1. Appropriate kinetic
2. Lack of absorption
3. Targeting by sonography or CT
4. Lack of toxicity
5. Lack of hemostasiologic disorders
Sonographic changes of metastatic lesions under 32p-colloid therapy
vor Therapie nach 1. fraktionierter Therapie nach 3. fraktionierter Therapie .
Sonographische Verlaufsuntersuchungen einer großen solitären Lebermetastase
vor Therapie
Sonographische Verlaufsuntersuchungen eines solitären metastatischen Prozesses des re. Leberlappens
3 Wochen nach fraktionierterTherapie
Pathologic anatomical changes after 3x 32p-colloid therapy in an advanced large solitary
metastases of liver
Conclusions
1. Locoregional 32p-colloid therapy is to be considered after systemic modalities
2. As a microinvasive therapy even possible in any problematic topographic locations
3. Within central part of solid tumors, effective dosis within a range of 1000 gray
4. Unifocal tumor formations are most adequate targets of this treatment