Adverse ReactionsThe complete absence of harmful effects, either immediate or delayed, when UBI is used property, has allowed clinical investigators to use this procedure over a period of twenty years and more on a single patient.

Citrate reactions.all typical citrate reactions, accompanied by headache, chill, temporary fever of not more than 102.0 degrees F., and moderate calf muscle spasm. This is less than 0.1%,

· Photosensitization (Light) Reactions sulfa drugs being the worst offenders. Iodide drugs can also be a problem, especially if given intravenously. Common non-photosensitive medications (ones that are OK to use with UBI) include penicillin, aspirin and other salicylates, broad-spectrum antibiotics, alkaloids, glucose, saline, and whole blood and plasma. It is our experience that psychotropic medications (pain pills, anxiety and depression pills) should be used with caution as UBI may increase their effect upon the body’s chemistry.

· Reactions due to death of bacteria (Herxheimer’s Reaction). This “die-off” reaction is usually similar to “flu-like” symptoms of headache, achiness, tiredness, and just “not feeling well” and usually lasts only several days.

· Exacerbation reaction’s in chronic diseases. Dr. Miley reports that in approximately 50% of individuals with bronchial asthma, nasal sinusitis and chronic rheumatic disease (also in acute rheumatic disease), there appears for the first four to five days following initial UBI an aggravation of the pre-existing symptoms which is usually no more severe than any previous severe exacerbation. This is especially true following the first application of UBI, much less likely to occur after a second UBI, and rarely after third.

· Possibility of producing shock. Other reactions. A rare and mildly depressant effect

influencing the synthesis of prostaglandinescracking of albumin moleculesimmunomodulationformation of antioxidative scavengersinfluencing the oxyen-binding properties of the red blood cellsmetabolic effects

Effects of photon therapy

Influence on synthesis of prostaglandinesCascade of arachidonic acid and inhibiting factors

phospholipase steroids

non-stero idal antiph log istics

throm boxane-synthesis

throm boxane-A 2

vasoconstriction

prostacycline

vasodilatation

prostacycline-synthesis

cyclooxigenase

biological effects:

- decreased plasma viscosity- antiinflamatory activity

Cracking of hydrogen-links in albumin molecules

stimulation of the physiological leucocytolysis Normal rate = 300000 per secondstimulation of unspecific phagocytosisincrease of the humoral germicide activity of the bloodincrease of the rate of T4-helper cells

Immunomodulation caused by ultraviolet blood irradiation

short living activated oxygen radicals act as a stimulant on blood cellsblood cells start the production of antioxidative enzymatic scavengerssomatic cells start the production of antioxidative enzymatic scavengers after retransfusion of the irradiated blood

Formation of antioxidativescavengers

increased intracellular concentration of 2,3 diphosphoglycerates in the erythrocytes causes a deviation to right at the oxigen binding curve

increasedO -capacity

2

decreasedO -capacity

2

“deviation to right”

physica l d i-solved O

2

O capacityHb fu lly satura ted(=1.00)

2

O binding curve o f the blood2

“deviation to le ft”

in blood

normalO -capacity

2

Easier oxygen supply to body tissues

1. parameters of the rheology of the blood decrease of plasma viscosity improvement of the flexibility of erythrocytes decrease of the aggregation tendency of red

blood cells decrease of the aggregation tendency of

thrombocytes decrease of plasmatic fibrinogen level decrease of plasmatic lipid levels

2. Haemodynamic important parameters dissolving of vasospastic phenomenons

Improvement of hemorheology and hemodynamic properties

improvement of microcirculationantiinflammatory effectsimprovement of the performance of the immunological systemprotection against oxidative stressimprovement of different metabolic activitiesimprovement of toxin clearance through connecting tissue, liver and kidneys

The most important biological effects of the ultraviolet blood irradiation

Physiological parameters influenced byultraviolet blood irradiation

Biophysical changes:Biophysical changes:-improvement of electrophoretical -improvement of electrophoretical

mobility of the erythrocytesmobility of the erythrocytes-increase of the electric charge of the -increase of the electric charge of the

erythrocyteserythrocytes-increase of the chemoluminescence -increase of the chemoluminescence

of the bloodof the blood- increase of the ATP-content of the - increase of the ATP-content of the

erythrocyteserythrocytes