Ag

CrFeNi

Gas emission of a diesel carGas emission of a diesel car

S. Domingo Chocolate

Bread from ModenaBread from Modena

From the fork to the From the fork to the farmfarm

Cookie

Al Si Cl Os

W

W

From the fork to the farmFrom the fork to the farm

Italian bread 1

Italian bread 2

Homogenized baby food

From the fork to the farmFrom the fork to the farm

Peach skin

Clam

W

W

Cauliflower soupCauliflower soup

Cauliflower soupCauliflower soup

1000 Km

Anchovy’s liver from the Adriatic sea

Co Cr W Nb Nd

Cl Sb

Environment is polluted by airborne nanoparticles, unintentionally released by high

temperature combustive processes.

Results of the research

Ni Group : nodules observed on both

sides (particles + bulk material) in all animals 6

months after implantation

Co Group : Nodules observed on the left side (nanoparticles IM) in all

cases 8 months after implantation

– nothing on the right side (bulk material implanted SC)

FP5- European Project

NANOPATHOLOGY

Nickel and Cobalt nanoparticles induced rabdomiosarcoma after 6-month

implantation in rats, the bulk samples only fibrotic capsules or

granulomas.

Co NPs

3T3 fibroblasts with Fe3O4 dry nanoparticles “free” in the nuclear area of a mitotic cell

0.1 mFP6- European Project-DIPNA

Factors influencing the pathogenicity of micro- and nanoparticles

PHYSICALForeign body

Size

Shape

Surface area state

Concentration

Intake velocity

Radioactivity

CHEMICALComposition

Corrodibility

Speciation

BIOLOGICALOrgan (cell) involved

Health condition

Individual variability

Thank you

www.worldscibooks.com/nanosci/v001.html

Nanopathology: the health impact of nanoparticles

Pan Stanford Publishing

We cannot hide the problems

The ability to think differently today from yesterday distinguishes the wise man from the stubborn.

J.Steinbeck (Nober Prize 1962)