agriculture, food, nutrition, and natural resources r&d roundtable · 2014-06-02 · ecology to...

NOMINATION FORM For Exemplary Collaborative Case Studies to Be Pres … American Association for the Advancement of Science/Washington, DC CENTER FOR NUTRITION & PREGNANCY 12/16/10 10:19 AM

http://www.zoomerang.com/Survey/WEB22BCW3D8BSZ of 22

NOMINATION FORM

FOR EXEMPLARY COLLABORATIVE CASE STUDIES TO BE PRESENTED AT THE

Agriculture, Food, Nutrition, and Natural Resources R&D

Roundtable

March 15, 2011 American Association for the Advancement of Science

Washington, DC

Questions marked with an asterisk (*) are mandatory. 1 *Title Center for Nutrition and Pregnancy 2 Collaborators NDSU:

• Biondini, Mario – Mathematical Modeling • Dorsam, Glenn – Epigenetics/Immunology/Molecular Biology • O’Rourke, Stephen – Cardiovascular Pharmacology • Reed, Wendy – Evolutionary Ecology/Maternal Effects • Schauer, Christopher – Animal Nutrition/Range Management • Stoltenow, Charlie - Epidemiology • Sun, Chengwen – Pharmacology/Central Blood Pressure Regulation

External: • Bieńko, Marek and Radzki, Radosław – Univ. of Life Sciences, Lublin, Poland –

Bone Physiology and Structure • Conley, Alan – UC-Davis – Physiology of Steroidogenic Pathways • Dhuyvetter, Dan – Ridley Inc., Mankato, MN – Commercial Animal Nutrition • Einarsson, Jon Ivar – Brigham and Women's Hospital Harvard Medical School –

Minimally Invasive Gynecologic Surgery • Ferreira Dias, Graça – Universidade Técnica de Lisboa, Portugal – Reproductive

Anatomy • Ford, Steve and Hess, Brett – Univ. of Wyoming – Reproductive

Physiology/Developmental Programming and Animal Nutrition • Fricke, Paul – Univ. of Wisconsin-Madison – Dairy Cow Reproduction/Extension • Funston, Rick- University of Nebraska-Lincoln—Reproductive

Physiology/Nutritional Physiology/Developmental Programming • Greenberg, James - Brigham and Women's Hospital Harvard Medical School –

Gynecologic Surgery • Hafez, Shireen – Alexandria Univ., Egypt – Vascular Anatomy of Female

Reproductive Organs



• Imumorin, Ikhide – Cornell Univ. – Quantitative Genetics/Epigenetics • Loi, Pasqualino – Universitá degli studi di Teramo, Italy – Animal

Embryology/Cloning • Longo, Larry – Center for Perinatal Biol., Loma Linda Univ. CA – Pregnacy

Physiology/Stress • Magness, Ronald – Univ. of Wisconsin-Madison – Perinatal Biology/Physiology • Musser, Rob – Kemin Industries, Des Moines, IA – Commercial Animal Nutrition • O’Rourke, Katherine – Animal Disease Res. Unit, USDA-ARS, Pullman, WA –

Microbiologist/Transmissible Spongiform Encephalopathies • Perry, George – South Dakota State Univ. - Reproductive

Physiology/Management • Scholljegerdes, Eric – New Mexico State Univ. – Animal Nutrition • Skarzynski, Dariusz - Polish Academy of Sciences, Olsztyn, Poland • Soto-Navarro, Sergio – New Mexico State Univ. – Animal Nutrition • Taylor, Brett – U.S. Sheep Exp. Sta., USDA-ARS, Dubois, ID –Animal Nutrition • Wallace, Jacqueline – Rowett Inst. of Nutr. & Health, Univ. Aberdeen, Scotland –

Nutritional Impacts on Pregnancy Outcomes • Wilson, Matthew – West Virginia Univ. – Animal Physiology/Stress • Wu, Guayao – Texas A&M Univ. – Nutritional Physiology/Developmental

Programming 3 *Key Investigators

• Bauer, Marc – Animal Nutrition • Berg, Eric – Meat Science/Muscle Biology • Berg, Paul – Meat Science/Animal Genetics • Borowicz, Pawel – Biological Imaging/Angiogenesis • Buchanan, David - Biostatistics • Caton, Joel – Co-Director – Nutrition-Reproduction Interactions/Developmental

Programming • Grazul-Bilska, Anna – Animal Embryology/Developmental Programming • Hammer, Carrie – Neonatal Physiology/Immunology • Johnson, Mary Lynn – Molecular Biology/Developmental Programming • Maddock Carlin, Kasey – Muscle Biology/Developmental Programming • Newman, David – Meat Science • Redmer, Dale – Reproductive Physiology/Developmental Programming • Reynolds, Larry – Nutrition-Reproduction Interactions/Developmental

Programming • Swanson, Kendall – Animal Nutrition/Energetics • Vonnahme, Kimberly – Co-Director – Nutrition-Reproduction

Interactions/Developmental Programming 4 *Description of Project The overall goal of the Center for Nutrition and Pregnancy (CNP) is to increase the proportion of healthy, productive offspring by ensuring an optimal maternal environment during pregnancy and lactation. This research area is extremely important because of



its tremendous potential socioeconomic impact. For example, various factors such as poor maternal nutrition, which lead to low birth weight, are major contributors to the high neonatal mortality in livestock and humans. In U.S. livestock, the rate of neonatal mortality is approximately 10% [1]. Compared with the rest of the developed world, the U.S. also suffers a high incidence of preterm birth and low birth weight in humans, which are major risk factors for infant mortality [2-4]. Moreover, in both humans and livestock, growth restricted offspring per se may be at risk not only of immediate postnatal complications but also may be ‘programmed’ to develop metabolic syndrome, poor growth, inappropriate body composition, immune dysfunction, reproductive failure, and poor cognitive development, as well as a host of other significant problems later in life – a concept that has been termed ‘Developmental Programming.’ In humans, Developmental Programming may perpetuate health problems and social difficulties over generations, whereas in livestock it impacts on meat, milk and fiber production and hence economic returns [5-10]. Since its inception in December 2002, the CNP has become one of the premiere centers in the U.S. addressing the impact not only of maternal nutrition but also various other factors as well (see below) on fetal and neonatal health and productivity (i.e., Developmental Programming). The CNP currently involves 15 Key Investigators 26 Collaborators from throughout the U.S. and the world. Importantly, as you can see from the list of Collaborators and Key Investigators, the CNP has brought together scientists from a wide range of disciplines, backgrounds and interests, from Biochemistry and Molecular Biology to Embryology to Evolutionary Ecology to Genetics, Nutrition, Pharmacology, Physiology and others. Importantly, however, the focus of their efforts is on determining how best to prevent or at least manage the negative consequences of Developmental Programming, with the ultimate goal of improving the health and productivity of the offspring from compromised pregnancies. Moreover, CNP investigators have published many review articles in international journals, organized and spoken at numerous international symposia, sat on numerous Federal grant review panels/focus groups, hosted several visiting scientists, and supervised many graduate and undergraduate students, all in the area of maternal nutrition and its role in Developmental Programming. Currently, studies in a variety of species (primarily sheep, swine, and cattle) are designed to understand how the following factors/stressors impact fetal and postnatal growth and development, and therefore health and productivity, of the offspring:

• Maternal nutritional intake around the time of conception • Maternal nutritional intake during pregnancy • Specific nutrients, such as selenium and protein, in the maternal diet • Maternal nutritional intake during early lactation • Maternal activity/exercise



• Maternal exposure to steroid hormones (e.g., corticoids, estrogens) • Maternal age (e.g., adolescence) • Maternal or fetal genotype • Singleton vs. multiple fetuses/offspring • Sex of the fetus/offspring • Assisted reproductive techniques (e.g., somatic cell nuclear transfer, in vitro

activation [parthenogenesis, androgenesis], in vitro fertilization) Based on our observations, we also have ongoing studies using various therapeutic and nutritional strategies designed to ‘rescue’ fetal growth and development that has been compromised by poor maternal nutrition. These strategies include specific nutrients (e.g., selenium, metabolizable protein) as well as dietary factors (e.g., Arginine) and drugs (e.g., sildenafil) that may increase nutrient delivery to the pregnant uterus. 5 *Primary Sources of Funding Because of the importance and potential socioeconomic impact of Developmental Programming, we have received funding for nearly 25 years from a variety of State and Federal agencies as well as from private companies within the livestock industry.

• North Dakota Agricultural Experiment Station • North Dakota State Board of Agricultural Research and Education • North Dakota Beef Commission • National Institute of Food and Agriculture

o Agriculture and Food Research Initiative (AFRI) • National Institutes of Health

o National Institute of Child Health and Human Development (NICHD) o National Heart, Lung, and Blood Institute (NHLBI) o Centers of Biomedical Research Excellence (COBRE) o IDeA Networks for Biomedical Research Excellence (INBRE)

• National Science Foundation o Experimental Program to Stimulate Competitive Research (EPSCoR) o Increasing the Participation and Advancement of Women in Academic

Science and Engineering Careers (ADVANCE) o Major Research Instrumentation Program (MRI)

• Diamond V Mills, Cedar Rapids, IA • Ridley Inc., Mankato, MN • Soda Inc., Mankato, MN (now Kemin Industries, Des Moines, IA)

6 *Duration The CNP was formally approved by the North Dakota State Board of Higher Education in December 2002, and has continued to be very active through today.



7 *Accomplishments As noted in the Description of Project section, since its inception only 8 years ago the CNP has become one of the premiere centers in the U.S. addressing the impact of not only maternal nutrition but also various other factors as well (see below) on fetal and neonatal health and productivity (i.e., Developmental Programming). Evidence for this includes our Key Investigators and Collaborators from throughout the U.S. and the world. In addition, CNP investigators have published numerous review articles, organized and spoken at numerous international symposia, sat on numerous Federal grant review panels/focus groups, hosted numerous visiting scientists, supervised many graduate and undergraduate students, all in the area of maternal nutrition and its role in Developmental Programming, and as documented in this section.

• Review Articles – Primary collaborators, as identified in Collaborators section, are underlined

o Lardy, G. P. and J. S. Caton. 2011. Beef Cattle Nutrition in Commercial Ranching Systems. In: Ruminant Nutrition Production Systems. UNESCO Books. In press.

o Caton, J. S. and B. W. Hess. 2010. Maternal plane of nutrition: Impacts on fetal outcomes and postnatal offspring responses. Invited review. Pages 104-122 in Proc. 4th Grazing Livestock Nutrition Conference. B. W. Hess, T. Delcurto, J. G. P. Bowman, and R. C. Waterman eds. West Sect. Am. Soc. Anim. Sci., Champaign, IL.

o Funston, R.N., D.L. Larson, and K.A. Vonnahme. 2010. Impacts of maternal nutrition on conceptus growth and offspring performance: Implications for beef cattle production. Invited review. J Anim Sci 88(13 suppl):E205-E215.

o Longo LD, Reynolds LP. Historical Perspective on placental developmental biology. Invited review. Internat J Develop Biol, Special Issue ‘Placental Developmental Biology,” JS Hunt and KL Thornburg (eds.) 2010; 54:237-255.

o Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, Luther JS, Buchanan DS, Hafez SA, Grazul-Bilska AT, Redmer DA. Utero-placental vascular development and placental function: An update. Invited review. Internat J Develop Biol, Special Issue ‘Placental Developmental Biology,” JS Hunt and KL Thornburg (eds.) 2010; 54:355-366.

o Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, Luther JS, Hammer CJ, Maddock Carlin KR, Grazul-Bilska AT, Redmer DA. Developmental programming: The concept, large animal models, and the key role of utero-placental vascular development. Invited review. J Anim Sci 2010; 88 (Suppl. 13):E61-E72.

o Caton, J. S. 2009. Significance of elevated selenium in muscle tissue: Functional food and nutrient reserve? Invited review. In: Selenium Deficiency, Toxicity, and Biofortification for Human Health. Eds. G. Banuelos, S. Lin, and X. Yin Eds. pp 57-58, University of Science and Technology of China Press. Hefei, China.



o Reynolds LP, Redmer DA, Grazul-Bilska AT, Vonnahme KA, Borowicz PP, Luther JS, Wallace JM, Spencer TE, Caton JS. Topical Review: Evidence for altered placental blood flow and vascularity in compromised pregnancies. Invited (Topical) review. J Physiol 2006; 572:51-58.

o Wallace JM, Luther JS, Milne JS, Aitken RP, Redmer DA, Reynolds LP, Hay WW Jr. Nutritional modulation of adolescent pregnancy outcome – A review. Invited review. Placenta 2006; 27 (Suppl. 1 [Trophoblast Research Vol. 20]): S61-S68.

o Reynolds LP, Borowicz PP, Vonnahme KA, Johnson ML, Grazul-Bilska AT, Redmer DA, Caton JS. Topical Review: Placental angiogenesis in sheep models of compromised pregnancy. Invited (Topical) review. J Physiol 2005; 565.1:43-58 (http://jp.physoc.org/cgi/reprint/565/1/43).

o Reynolds LP, Borowicz PP, Vonnahme KA, Johnson ML, Grazul-Bilska AT, Wallace JM, Caton JS, Redmer DA. Animal models of placental angiogenesis. Invited review. Placenta 2005; 26:689-708.

o Reynolds LP, Biondini ME, Borowicz PP, Grazul-Bilska AT, Vonnahme KA, Caton JS, Redmer DA. Functional significance of developmental changes in placental microvascular architecture: The sheep as a model. Invited review. Endothelium 2005; 12:11-19.

o Luther JS, Redmer DA, Reynolds LP, Wallace JM. Nutritional paradigms of ovine fetal growth restriction: Implications for human pregnancy. Invited Review. Human Fertility 2005; 8:179-187.

o Redmer DA, Wallace JM, Reynolds LP. 2004. Effects of nutrient intake during pregnancy on fetal and placental growth and vascular development. Invited review. Domestic Anim Endocrinol 27:199-217.

o Reynolds LP., Grazul-Bilska AT, Redmer DA. 2002. Angiogenesis in the Female Reproductive System: Pathological Implications. Review Article. Int. J. Exp. Pathol. 83:151-164.

• Additional Peer-Reviewed Articles – Primary collaborators, as identified in Collaborators section, are underlined

o Borowicz PP, Reynolds LP. Placental programming: More may still be less. Perspective. J. Physiol. 2010; 588:393.

o Grazul-Bilska AT, Borowicz PP, Minten MA, Johnson ML, Bilski JJ, Redmer DA, Reynolds LP. Placental development during early pregnancy in sheep: Vascular growth and expression of angiogenic factors in maternal placenta. Reproduction 2010; 140:165-174.

o Hafez S, Borowicz P, Reynolds L, Redmer D. Maternal and fetal microvasculature in sheep placenta across several stages of gestation. J Anat 2010; 216:292-300 (a figure from this paper appeared on the journal cover, March 2010).

o Lekatz, L.A., J.S. Caton, J.B. Taylor, L.P. Reynolds, D.A. Redmer, and K.A. Vonnahme. 2010. Maternal selenium supplementation and timing of nutrient restriction in pregnant sheep: Impacts on maternal endocrine status and placental characteristics. J Anim Sci. 88:955-971.

o Lekatz, L.A., Wu G., J.S. Caton, J.B. Taylor, L.P. Reynolds, D.A. Redmer, and K.A. Vonnahme. 2010. Maternal selenium supplementation and timing



of nutrient restriction in pregnant sheep: Impacts on nutrient availability to the fetus. J Anim Sci. 88: In press.

o Lekatz, L. A., M. A. Ward, P. P. Borowicz, J. B. Taylor, D. A. Redmer, A. T. Grazul-Bilska, L. P. Reynolds, J. S. Caton, and K. A. Vonnahme. 2010. Cotyledonary responses to maternal selenium and dietary restriction may influence alterations in fetal weight and fetal liver glycogen in sheep. Anim. Reprod. Sci. 117:216-225.

o Luther J, Aitken R, Milne J, McArdle H, Gambling L, Reynolds L, Redmer D, Wallace J. Liver iron status and associated haematological parameters in relation to fetal growth and pregnancy outcome in rapidly growing adolescent sheep carrying a singleton lamb derived by embryo transfer. Reprod Fert Develop 2010; 22:1230-1236.

o Meyer AM, Reed JJ, Neville TL, Taylor JB, Hammer CJ, Reynolds LP, Redmer DA, Vonnahme KA, Caton JS. Effects of nutritional plane and selenium supply during gestation on ewe and neonatal offspring performance, body composition, and serum selenium. J Anim Sci 2010; 88:1786-1800.

o Meyer AM, Reed JJ, Vonnahme KA, Soto-Navarro SA, Reynolds LP, Ford SP, Hess BW, Caton JS. Effects of stage of gestation and nutrient restriction during early to mid-gestation on maternal and fetal visceral organ mass and indices of jejunal growth and vascularity in beef cows. J Anim Sci 2010; 88:2410-2424.

o Neville TL, Caton JS, Hammer CJ, Reed JJ, Luther JS, Taylor JB, Redmer DA, Reynolds LP, Vonnahme KA. Ovine offspring growth and diet digestibility are influenced by maternal Se supplementation and nutritional intake level during pregnancy despite a common postnatal diet. J Anim Sci. 2010; 88:3645-3656.

o Neville TL, Redmer DA, Borowicz PP, Reed JJ, Ward MA, Johnson ML, Taylor JB, Soto-Navarro SA, Vonnahme KA, Reynolds LP, Caton JS. Maternal dietary restriction and selenium supply alters mRNA expression of angiogenic factors in maternal intestine, mammary gland, and fetal jejunal tissues during late gestation in pregnant ewe lambs. J Anim Sci 2010; 88:2692-2702.

o Vonnahme KA, Luther JS, Reynolds LP, Hammer CJ, Carlson DB, Redmer DA, Caton JS. Impacts of maternal selenium and nutritional level on growth, adiposity, and glucose tolerance in female offspring in sheep. Domestic Anim Endocrinol 2010; 39:240-248.

o Carlson DB, Reed JJ, Borowicz PP, Taylor JB, Reynolds LP, Neville TL, Redmer DA, Vonnahme KA, Caton JS. Effects of dietary selenium supply and timing of nutrient restriction during gestation on maternal growth and body composition of pregnant adolescent ewes. J Anim Sci 2009; 87: 669-680.

o Caton JS, Reed JJ, Aitken RP, Milne JS, Borowicz PP, Reynolds LP, Redmer DA, Wallace JM. Effects of maternal nutrition and stage of gestation on body weight, visceral organ mass, and indices of jejunal cellularity, proliferation, and vascularity in pregnant ewe lambs. J. Anim Sci. 2009; 87(1):222-235.



o Caton, J. K. Vonnahme, J. Reed, T. Neville, C Effertz, C. Hammer, J. Luther, D. Redmer, and L. Reynolds. 2007. Effects of maternal nutrition on birth weight and postnatal nutrient metabolism. Proceedings, International Symposium on Energy and Protein Metabolism. Vichy, France. EAAP Publication No. 124:101-102.

o Grazul Bilska AT, Caton JS, Arndt W, Burchill K, Thorson C, Borowczyk E, Bilski JJ, Redmer DA, Reynolds LP, Vonnahme KA. Cellular proliferation and vascularization in ovine fetal ovaries: Effects of undernutrition and selenium in maternal diet. Reproduction 2009; 137:699-707.

o Redmer DA, Luther J, Milne J, Aitken R, Johnson M, Borowicz P, Borowicz M, Reynolds LP, Wallace J. Fetoplacental growth and vascular development in overnourished adolescent sheep at day 50, 90 and 130 of gestation. Reproduction. 2009; 137:749-757.

o Taylor JB, Reynolds LP, Redmer DA, Caton JS. Maternal and fetal tissue selenium loads in nulliparous ewes fed supranutritional and excessive selenium during mid- to late pregnancy. J Anim Sci. 2009; 87:1828-1834.

o Borowicz PP, Hafez S, Redmer DA, Reynolds LP. 2008. Chapter 10. Methods for evaluating uteroplacental angiogenesis and their application using animal models. In: Methods in Enzymology, Vol. 445, Angiogenesis, In Vivo, Part B. pp. 229-53. (D Cheresh, ed.), Elsevier, NY.

o Evoniuk JM, Borowicz PP, Caton JS, Vonnahme KA, Reynolds LP, Taylor JB, Stoltenow CL, O'Rourke KI, Redmer DA. Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placenta. Placenta 2008; 29:422-428.

o Neville TL, Ward MA, Reed JJ, Soto-Navarro SA, Julius SL, Borowicz PP, Taylor JB, Redmer DA, Reynolds LP, Caton JS. Effects of level and source of dietary selenium on maternal and fetal body weight, visceral organ mass, cellularity estimates, and jejunal vascularity in pregnant ewe lambs. J Anim Sci 2008; 86:890-901.

o Swanson, T.J. Hammer, C.J., Luther, J.S., Carlson, D.B., Taylor, J.B., Redmer, D.A., Neville T.L., Reed J.J., Reynolds L.P., Caton J.S., Vonnahme, K. A. Effects of gestational plane of nutrition and selenium supplementation on mammary development and colostrum quality in pregnant ewe lambs. J Anim Sci 2008; 86:2415-2423.

o Vonnahme, K.A., J. Evoniuk, M.L. Johnson, P.P. Borowicz, D.A. Redmer, L.P. Reynolds, and A.T. Grazul-Bilska. Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep. Endocrine 2008; 33:53-61.

o Vonnahme, K.A., W.J. Arndt, M.L. Johnson, P.P. Borowicz, and L.P. Reynolds. Effect of morphology on placentome size, vascularity, and vasoreactivity in late pregnant sheep. Biol. Reprod. 2008. 79:976-82.

o Ward, M. A., T. L. Neville, J. J. Reed, J. B. Taylor, D. M. Hallford, S. A. Soto-Navarro, K. A. Vonnahme, D. A. Redmer, L. P. Reynolds, and J. S. Caton. Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs. J. Anim Sci. 2008; 86:1254-1262.



o Borowicz PP, Arnold DR, Johnson ML, Grazul-Bilska AT, Redmer DA, Reynolds LP. Placental growth throughout the last two-thirds of pregnancy in sheep: Vascular development and angiogenic factor expression. Biol Reprod 2007; 76:259-267 (A top-cited article appearing in the 2007-08 issues of Biology of Reproduction).

o Caton, J. S., A. T. Grazul-Bilska, K. A. Vonnahme, J. S. Luther, G. P. Lardy, C. J. Hammer, D. A. Redmer, and L. P. Reynolds. 2007. Nutritional management during gestation: impacts on lifelong performance. Invited presentation. Proc.18th Annual Florida Ruminant Nutrition Symposium. Pages 144-163.

o Luther J, Aitken R, Milne J, Matsuzaki M, Reynolds L, Redmer D, Wallace J. Maternal and fetal growth, body composition, endocrinology, and metabolic status in undernourished adolescent sheep. Biol Reprod 2007; 77:343-350.

o Luther J, Milne J, Aitken R, Matsuzaki M, Reynolds L, Redmer D, Wallace J. Placental growth, angiogenic gene expression, and vascular development in undernourished adolescent sheep. Biol Reprod 2007; 77:351-357.

o Palmieri C, Loi P, Reynolds LP, Ptak G, Della Salda L. Placental abnormalities in ovine somatic cell clones at term: A light and electron microscopic investigation. Placenta 2007; 28:577-584.

o Reed JJ, Ward MA, Vonnahme KA, Neville TL, Julius SL, Borowicz PP, Taylor JB, Redmer DA, Grazul-Bilska AT, Reynolds LP, Caton JS. Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass and cellularity estimates, and jejunal vascularity in pregnant ewe lambs. J. Anim Sci. 2007; 85:2721-2733.

o Vonnahme KA, Zhu MJ, Borowicz PP, Geary TW, Hess BW, Reynolds LP, Caton JS, Means WJ, Ford SP. Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome. J. Anim Sci. 2007; 85:2464-2472.

o Borowczyk, E. D. A. Redmer, J. S. Caton, J. J. Bilska, R. M. Weigl, D. Rouse, K. A. Vonnahme, P. P. Borowicz, L. P. Reynolds, and A. T. Grazul-Bilska. 2006. Effects of plane of nutrition on in vitro fertilization (IVF) and early embryonic development in sheep. J. Anim. Sci. 84:1593-1599.

o Echternkamp S.E., Vonnahme K.A., Green J.A., Ford S.P. 2006. Increased vascular endothelial growth factor and pregnancy-associated glycoproteins, but not insulin-like growth factor-I, in maternal blood of cows gestating twin fetuses. J. Anim. Sci. 84:2057-2064.

o Grazul-Bilska AT, Pant D, Luther JS, Borowicz PP, Navanukraw C, Caton JS, Ward MA, Redmer DA, Reynolds LP. Pregnancy rates and gravid uterine parameters in single, twin and triplet pregnancies in naturally bred ewes and ewes after transfer of in vitro produced embryos. Anim Reprod Sci 2006; 92: 268-283.

o Caton, J. S. K. A. Vonnahme, D. A. Redmer, P. P. Borowicz, M. A. Ward, C. E. Oliver, J. J. Reed, M. L. Johnson, M. L. Bauer, and L. P. Reynolds.



2005. Effects of maternal nutrition on intestinal growth, development, and vascularity in ruminants. Proc, Colorado Nutrition Roundtable (Invited).

o Encinias AM, Lardy GP, Leupp JL, Encinias HB, Reynolds LP, Caton JS. Efficacy of using a combination of rendered protein products as an undegradable intake protein supplement for lactating, winter-calving, beef cows fed bromegrass hay. J Anim Sci 2005; 83:187-195.

o Luther JS, Redmer DA, Reynolds LP, Wallace JM. Nutritional paradigms of ovine fetal growth restriction: Implications for human pregnancy. Invited Review. Human Fertility 2005; 8:179-187.

o Redmer DA, Aitken RP, Milne JS, Reynolds LP, Wallace JM. Influence of maternal nutrition on messenger RNA expression of placental angiogenic factors and their receptors at mid-gestation in adolescent sheep. Biol Reprod 2005; 72: 1004 - 1009.

o Taylor JB, Finley JW, Caton JS. Effect of chemical form of supranutritional selenium on selenium load and selenoprotein activities in virgin, pregnant, and lactating rats. J Anim Sci 2005; 83: 422-429.

o Vonnahme K.A., M.E. Wilson, Y. Li, H.L. Rupnow, T.M. Phernetton, S.P. Ford, R.R. Magness. 2005. Circulating levels of nitric oxide and vascular endothelial growth factor throughout ovine pregnancy. J Physiol. 565:101-109.

o Scheaffer, A.N., J.S. Caton, D.A. Redmer, D.R. Arnold and L.P. Reynolds. 2004. Effect of dietary restriction, pregnancy, and fetal type on intestinal cellularity and vascularity in Columbia and Romanov ewes. J. Anim. Sci. 82:3024-3033.

o Scheaffer, A. N., J.S. Caton, D.A. Redmer, and L.P. Reynolds. 2004. The effect of dietary restriction, pregnancy, and fetal type in different ewe types on fetal weight, maternal body weight, and visceral organ mass in ewes. J. Anim. Sci. 82:1826-1838.

o Scheaffer, A.N., J.S. Caton, M.L. Bauer, and L.P. Reynolds. 2003. The impact of pregnancy on visceral growth and energy use in beef heifers. J. Anim. Sci. 81:1853-1861.

• Grants Received o PHS Grant NHLBI 64141-01-04 "The major angiogenic factors in placental

angiogenesis"; $425,000 total direct costs; February 2001-January 2005 o NSF-EPSCoR Grant, Infrastructure Improvement Program (IIP)

"Instrumentation for high-throughput isolation, analysis, and quantification of RNA and DNA"; $78,876 total direct costs; April 2002-June 2002

o NSF Equipment Grant “Confocal microscopy system for physiological and endocrinological studies”; $60,099 total direct costs plus and additional $35,000 local matching funds; May 2003-April 2005

o NSF-EPSCoR Grant, “Confocal Microscope for Biological and Biomedical Studies,” $5,050 total direct cots, April 2003-March 2004

o NSF-INBRE Grant, “IDeA Networks for Biomedical Research Excellence” – Director, Cell Biology Core Laboratory, and Mentor, “Effect of MCPA, 2,4-D and bromoxynil on lung development (Dr. Hilde van Gijssel); $274,675 total direct costs, August 2004-May 2009



o USDA ARS Animal Disease Research Unit, Specific Cooperative Agreement SCA-58-5348-3-233, "Eradication of ovine scrapie TSE through selective genetics using a two flock model, $240,000 total direct costs, Sept. 3, 2003 - Sept. 14, 2007.

o USDA, NRI Conference Grant – FASEB Summer Research Conference “Molecular & Cellular Signaling in the Perinatal Cardiovascular System”; $10,000 total direct costs, August 2004-July 2005

o USDA-CSREES-NRI “Effects of maternal undernutrition and high selenium during gestation on growth and vascularization of key nutrient transferring tissues” $442,000 total costs, Dec 2004 to Nov. 2009

o PHS Grant NICHD 45784-01-05 "Nutrition, fetal growth, and placental angiogenesis"; $1,210,000 total direct costs; April 2005-March 2010

o USDA, NRI Conference Grant – Aspen Perinatal Biology Symposium, “Interaction of Maternal, Placental and Fetal Systems in Perinatal Development”; $10,000 total direct costs, July 2007-August 2008

o USDA, NRI Grant 2007-01215, “Epigenetics of Placental Angiogenesis in Cloned and Monoparental Sheep Fetuses”; $315,000 total direct costs, September 2007-August 2010

o PHS Grant NHLBI R03-HD061532-01-02, “Undernutrition in Pregnancy and Developmental Programming of Vascular Function”; $100,000 total direct costs, September 2009-August 2011

o ND SBARE “Visualizing and quantifying vascular architecture in key nutrient transferring tissues of ruminant livestock” $6,493 total costs. Jan 08 to Dec 08

o ND SBARE “Does Glucagon Like Peptide-2 (GLP2) improve intestinal function and health in ruminants?” $6,758 total costs, Jan 08 to Dec 08

o ND SBARE “Influence of maternal dietary intake and selenium level on postnatal performance and intestinal function”. $8,192 total costs, Jan 08 to Dec 08

o USDA-AFRI “Strengthening research capacity in developmental programming: Effects of maternal nutrition on perinatal intestinal growth and vascularity”; $67,244 total costs Aug 2009 to Aug 2010

o ND SBARE, “Ruminal by-pass supplementation of L-Arginine in ruminants: Impacts on reproduction”; $8,760 total costs, April 2009 to March 2010.

o USDA-AFRI, Conference Grant, “Intrauterine stress and adverse fetal outcomes: Linked by perinatal mechanisms of adaptation”; $10,000 total costs, November 2009 to October 2010

o ND SBARE “Ruminally undegradable protein supplementation of beef cows nutrient restricted during early to mid-gestation: Impacts on maternal metabolic state and offspring feed efficiency and intestinal vascularity;” $7,236 total costs, May 2010 to June 2011

o NSF MRI-R2 program, “Acquisition of laser microdissection and pressure catapulting system (LMPCS) for life sciences research and training;” $500,667 total costs, 2009-2012.



o ND EPSCoR, Women in sciences and engineering program (PI), “Acquisition of laser microdissection and pressure catapulting system (LMPCS) for life sciences research and training”$13,634 total costs, 2010.

o USDA, Agriculture and Food Research Initiative (AFRI), Proposal number 2009-65203-05696, "Strengthening research infrastructure through improving stereoscopy and imaging capabilities in agriculture sciences"; $28,633 direct costs + $28,633 NDSU match, Sept. 2009 - Aug. 2010.

o USDA, Agriculture and Food Research Initiative (AFRI), “Early nutritional impacts on uteroplacental blood flow and vascular reactivity in pregnant cows;” $320,000 total costs, 2009.

o USDA, Agriculture and Food Research Initiative (AFRI), “Influence of metabolizable protein supplementation in late pregnancy on offspring feed efficiency, carcass quality and fertility in sheep;” $350,000 total costs, 2009.

o NSF Advance FORWARD Leap Grant, “Influence of maternal endocrine and metabolic status on offspring growth and performance;” $23,000 total costs, 2009.

o Five States Ruminant Consortium, “Economic impacts of protein supplementation during late gestation on rebreeding in cows and effects on growth, development and carcass characteristics of steers calves.” Co-PD (portion of grant, $9,478 total costs) with Investigators from Univ. Nebraska-Lincoln, South Dakota State Univ., and Univ. Wyoming. 2009.

o ND Beef Commission, “Use of young female gilts as a biomedical model of human females to determine if consumption of beef from cattle administered estrogenic growth promotants results in premature puberty and obesity;” $30,000 total costs, 2009.

o ND State Board of Agriculture Research and Education, “Impacts of maternal exercise on litter size, offspring growth, and muscle fiber characteristics;” $10,270 total costs, 2009.

• Symposia organized o Co-Chair/Co-Organizer and also Session Chair, 3rd FASEB Summer

Research Conference on Perinatal Regulation of the Cardiovascular System, Tucson, AZ; August 2004.

o Facilitator, NIH-NIDDK Mtg. on The Intrauterine Environment: Long-term Consequences for Obesity and Metabolic Disease (co-sponsored by NHLBI, NICHD, and NIEHS), North Bethesda, MD; September 2005

o Invited Speaker and Workshop Participant, NIH/USDA Workshop: Advantages of Agriculturally Important Domestic Species as Biomedical Models (co-sponsored by NICHD, NIGMS, NHLBI, NIAID of NIH, and by USDA-CSREES NRI); Bethesda, MD; April 2007

o Co-organizer and Session Chair, 1st Aspen Perinatal Biology Symposium on Interaction of Maternal, Placental and Fetal Systems in Perinatal Biology, Aspen, CO (co-sponsored by NIH, March of Dimes, USDA-NRI, Abbott Laboratories, University of Cincinnati, University of Colorado, and North Dakota State University); August 2007



o Workshop organizer and presenter “Perinatal Metabolic Programming”, International Symposium on Energy and Protein Metabolism (ISEP), Vichy France 2007.

o Member, International Scientific Committee and Session Chair, Reproductive Bioengineering 2008, Wenns am Piztal, Austria; April 2008

o Member, Organizing Committee (Chair, utero-placental function and placentation session), 8th International Ruminant Reproduction Symposium, Anchorage, Alaska; September 2010

o Co-organizer (member of 3-person committee), Perinatal Programming of Offspring Symposium, Western Section, American Society of Animal Science, Denver, CO, July 2010

o Member, Organizing Committee, 2nd Aspen Perinatal Biology Symposium on Intrauterine Stress and Adverse Fetal Outcomes: Linked by Perinatal Mechanisms of Adaptation, Aspen, CO; August 2010

o Co-organizer, 2nd Aspen Perinatal Biology Symposium on Intrauterine Stress and Adverse Fetal Outcomes: Linked by Perinatal Mechanisms of Adaptation, Aspen, CO; August 2010

o Organizing Committee (Chair, Utero-Placental Function and Placentation session), 8th Internat. Ruminant Reproduction Symposium, Anchorage, Alaska, September, 2010

o Co-organizer, 2nd international Conference on Selenium in the Environment and Human Health, Suzhou, China October 2011

o Organizer of Midwest ASAS Physiology Symposium and session chair “Factors influencing placental function” Des Moines IA March 2010

• Visiting Professorships o 2001-2002, Visiting Scientist, Developmental Leave, Rowett Research

Institute, Aberdeen, UK. o Functional significance of developmental changes in placental

microvascular architecture: The sheep as a model;" Visiting Professorship in Biomedical Sciences, Loma Linda University School of Medicine, Loma Linda CA; November 2004

o “Cell model systems and methods in ovarian function;” NIH-INBRE Visiting Professorship in Cell Biology, Valley City State University, Valley City, ND; December 2004

o Visiting Professorship in Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Italy; Four presentations:(1) “Understanding the Basis of Fetal Programming of Adult Disease: Sheep Models of Compromised Pregnancy,” (2) “A New Model for Control of Ovarian Angiogenesis by VEGF and NO,” (3) “Regulation of Placental Angiogenesis during Early Pregnancy in Sheep,” and (4) “Functional Significance of Developmental Changes in Placental Microvascular Architecture: The Sheep as a Model;” May 2005

o 2009-2010, Hon. Research Fellow, Sabbatical Leave, Rowett Inst. of Health and Nutrition, Univ. Aberdeen, UK

• Keynote Speakerships o “Angiogenesis in the female reproductive organs;” Keynote Address,

American Society for Reproductive Immunology, Chicago, IL; June 2002.



o Invited keynote presentation "Fetal programming: Role of maternal nutrition during pregnancy." 96th Annual Meeting of the North Dakota Academy of Science, Fargo, April 2004.

o “The role of the maternal environment on fetal and placental growth.” The Kings Lectureship, Univ. of Arkansas; November 2005.

o Invited keynote presentation "Vasculature of the Reproductive System and the Vessels of Life - One of God's Beautiful Designs." Great Plains Natural Science Symposium, Northwestern College, Orange City, IA; April 2006.

o “Fetal programming of adult disease and its potential impact on animal production;” 2005-06 Keynote Speaker, Graduate Student Association, Department of Animal Science, University of Nebraska-Lincoln; April 2006.

o “Developmental Origins of Health and Disease in Humans and Farm Animals: Long-Term Implications and Potential Solutions;” Keynote Address, Fall 2008, North Dakota State University Chapter, Phi Kappa Phi Honor Society; November 2008.

o “Placental programming and life-long health and productivity,” Invited Keynote Speaker, National Farm Management Conference, Fargo, ND; June 2010.

• Invited National/International Symposium Presentations o "Effects of nutrient intake during pregnancy on fetal and placental growth

and vascular development". Invited Symposium Presentation. 54th Annual Meeting of the European Association for Animal Production, Rome, Italy. Sept. 1, 2003.

o “Maternal and fetal factors affecting placental angiogenesis: Implications for animal health and productivity;” International Congress on Sheep Production: Between Tradition, Research and Development, Department of Comparative Biomedical Science, University of Teramo, Italy; June 2004.

o “National Institutes of Health – Organization and Insights to Grant Formulation Strategies;” Workshop on Perspectives, Insights and Tools for Animal Scientists to Obtain USDA and NIH Funding, American Society of Animal Science, St. Louis, MO; July 2004.

o “Genetic and maternal factors affecting placental vascular development in sheep;” FASEB Summer Research Conference, Molecular and Cellular Signaling in the Perinatal Cardiovascular System, Tucson, AZ; August 2004.

o “Developmental origins of adult health and productivity: Implications for animal production,” Iowa State University Animal Science Departmental Seminar, February 2005.

o “Effects of maternal nutrition on fetal intestinal development” Colorado Nutrition Round Table, Denver, 2005.

o “Effects of maternal nutrition on intestinal growth, development, and vascularity in ruminants” Amer. Feed Industry Assoc., Kansas City, 2005.

o “Increasing selenium in meat and milk through nutrition,” Midwest Amer. Soc. Anim. Sci. meetings, Des Moines, IA, March 2006.



o “Nutrition and management during gestation: impacts on lifelong performance”, Amer. Soc. Anim. Sci. meetings, July 2006.

o “Where health begins: a look at how nutrition during pregnancy may impact livestock production,” Purdue University. Animal Science Departmental Seminar, November 2006.

o “Developmental programming of adult disease: Understanding the impact on human health and animal production;” NIH/USDA Workshop on Advantages of Agriculturally Important Domestic Species as Biomedical Models; Bethesda, MD; April 2007.

o “Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development;” 4th International Conference on the Female Reproductive Tract, Kloster Frauenwörth, Frauenchiemsee, Germany; June 2007.

o “Nutrition and management during gestation: Impacts on lifelong performance”, Florida Ruminant Nutrition Symposium, February 2007.

o “Effect of In-utero nutrition on subsequent offspring performance” Amer. Feed Industry Assoc., Scottsdale AZ Sept 2007.

o “Impacts of maternal nutrition and specific nutrients on fetal and neonatal organ development in sheep,” Aspen Perinatal Biology Symposium, August 2007.

o “Nutrition during gestation and fetal programming,” The Range Beef Cow Symposium XX, Fort Collins, CO, December 2007.

o “Influence of maternal nutrition on offspring performance,” Physiology Symposium, Midwestern Amer. Soc. Anim. Sci., March 2008

o “Impacts of Maternal Nutrition on Pregnancy and Offspring Performance,” Pfizer and Rocky Mountain Supply Appreciation Days, Belgrade, Dillion, and Townsend, MT, March 2008.

o “Placental microvascular growth: Implications for compromised pregnancy”; Reproductive Bioengineering 2008, Wenns im Pitztal, Austria; April 2008.

o “Fetal nutrition and offspring performance in ruminants,” Asociación Mexicana de Producción Animal, Monterrey. Mexico 2008.

o “Effect of in-utero nutrition on subsequent offspring performance.” Florida Professional Ranchers Symposium, April 2008.

o “Advantages of domestic animals as dual-purpose models that benefit agricultural and biomedical research,” Domestic Animal Biomedical Embryology (DABE) Symposium, International Embryo Transfer Society, San Diego, CA, January 2009.

o “Life before birth: Impacts of maternal offspring performance in livestock,” Invited talk, Ohio State Univ. Animal Science Graduate Student Organization, May 2009.

o “Angiogenesis in uterus and placenta”, Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, Germany; June 2009.

o “They are what Mama eats: Impacts of maternal nutrition on pregnancy and offspring performance,” Pfizer Animal Health’s Annual Summer Veterinarian Meeting. Devil’s Lake, ND, June 2009.



o “Background and philosophies,” ASAS Graduate Student Luncheon, American Society of Animal Science, Montreal, Canada; July 2009.

o “Large animal models of Developmental Programming;” Growth and Development Symposium, American Society of Animal Science, Montreal, Canada; July 2009.

o “Uteroplacental vascular development and placental function: An update;” President’s Symposium, Annual Meeting, Perinatal Research Society, Mohonk House, New Paltz NY, September 2009.

o “Uteroplacental vascular development and placental function: An update;” Reproductive Biology Interdisciplinary Program, Texas A&M University, October 2009.

o “Significance of elevated selenium in muscle tissue: Functional food and nutrient reserve?” 1st International Conference on Selenium in the Environment and Human Health, Suzhou, China, October 2009

o “Placental programming and life-long health and productivity,” Physiology Symposium, Midwestern Section, American Society of Animal Science, Des Moines, IA, March 2010.

o “If mama ain’t happy, ain’t nobody happy: Effect of maternal environment on nutrient delivery to her offspring,” Texas A&M Reproductive Biology Forum, April 2010.

o “Maternal plane of nutrition: Impacts on fetal outcomes and postnatal offspring responses,” 4th Grazing Livestock Conference, Estes Park. CO 2010.

o “Angiogenesis in uterus and placenta: animal model”, Veterinary School of Lisbon Technical University, Lisbon, Portugal; June 2010.

o “Maternal nutrition and developmental programming: Impacts on development and function of the gastrointestinal system in offspring,” Symposium on Impacts of In Utero Programming. Amer. Soc. of Animal Sci., Denver, CO; July 2010.

o “Taking the reins: Transitioning from PhD student to Associate Professor,” Graduate Student Symposium, Amer. Soc. of Animal Sci., Denver, CO; July 2010.

o “Impact of plane of nutrition (on perinatal programming of offspring),” 2nd Aspen Symposium on Perinatal Biology, Aspen, CO; August 2010.

o “Cell proliferation, apoptosis, vascularization and gap junctions in fetal ovaries: effects of maternal diet and implications for fetal programming”, 2nd Aspen Symposium on Perinatal Biology, Aspen, CO, August 2010.

o “Impact of Developmental Programming in livestock production (or, How maternal nutrition might determine lifetime productivity of her offspring),” Conference on Nutritional Regulation of the Genome, Continuing Education Conference, California Branch, American Registry of Professional Animal Scientists, Coalinga, CA; October 2010.



• Awards/Recognition Received o Caton, JS – Eugene R. Dahl Award for Excellence in Research, Senior

Career, College of Agriculture, North Dakota State Univ. and ND Agric. Exp. Sta., 2003

o Vonnahme, KA – USDA-NRI Travel Fellowship for Annual Meeting Soc. Study Reprod., 2003

o Caton, JS – The American Society of Animal Science Award in Ruminant Nutrition, Amer. Feed Industry Assoc.; For research contributions and excellence in the previous 10-yr period, 2004

o Vonnahme, KA – British Columbia Research Institute for Children’s and Women’s Health Travel Grant for Annual Meeting Soc. Study Reprod., 2004

o Vonnahme, KA – Larry Ewing Memorial Trainee Travel Award for Annual Meeting Soc. Study Reprod., 2004

o Vonnahme, KA – Young Investigator Travel Award for Annual Meeting Perinatal Res. Soc., Banff, Canada, 2005

o Vonnahme, KA – NIH Loan Repayment Program Award, 2005 o Reynolds, LP – Eugene R. Dahl Award for Excellence in Research, Senior

Career, College of Agriculture, North Dakota State Univ. and ND Agric. Exp. Sta., 2006

o Vonnahme, KA – Larson-Yaggie Research Award, Early Career, North Dakota State Univ. and ND Agric. Exp. Sta., 2006

o Reynolds, LP – The American Society of Animal Science Award in Animal Physiology and Endocrinology for research contributions and excellence in the previous 10-yr period, 2007

o Reynolds, LP – University Distinguished Professor, North Dakota State University, Fargo, ND, 2008

o Vonnahme, KA – Earl and Dorothy Foster Excellence in Teaching, North Dakota State Univ. and ND Agric. Exp. Sta., 2008

o Reynolds, LP – 51st Faculty Lectureship, A Womb with a View: How Fetal Development Affects Adult Health, North Dakota State University, April 2009

o Vonnahme, KA – Midwestern American Society of Animal Science Young Scientist Early Career Teaching Award, 2010

8 *Impact The wide variety of activities by CNP investigators, as documented in the Accomplishments section, have contributed not only to international recognition of the CNP but more importantly to wide recognition of Developmental Programming as a major issue contributing to the health and productivity of animals and humans alike. Important to these efforts has been the role of CNP investigators in training of other investigators, assisting granting agencies in planning and evaluating proposals, evaluating papers for various journals and other publications, and the educating of undergraduate and graduate students, all related to maternal nutritional and other factors contributing to Developmental Programming. A particularly notable part of these



efforts has been the training of 14 Postdoctoral Fellows, 60 Graduate Students, and more than 100 Undergraduate Research Interns.

• Visiting Scientists, Postdoctoral Fellows, and Students Supervised o Visiting Scientists – 3 o Postdoctoral Fellows – 14 o Ph.D. Students – 21 o M.S. Students – 39 o Undergraduate Research Interns – 114

• Grant Committees Served On o 37 @ NIH and NIFA-AFRI (formerly USDA-NRI), including 4 as chair

• Focus groups served on o NHLBI Working Group – The Influence of Early Programming in the

Development of Cardiovascular, Lung, Blood, and Sleep Disorders (http://www.nhlbi.nih.gov/meetings/workshops/earlyprg.htm)

o Advantages of Domestic Species as Dual-Use Models that Benefit Agricultural and Biomedical Research (http://www.adsbm.msu.edu/Home/tabid/54/Default.aspx) – workshop participant and co-author of numerous publications including recommendations (e.g., see [11])

• Editorships/Editorial Boards o Editorships

Caton – Associate Editor, Journal of Animal Science – 2004-06 Reynolds – Editor-in-Chief, Journal of Animal Science – 2005-08 Reynolds – Editor-in-Chief, Animal Science Image Gallery, National

Agricultural Library (http://anscigallery.nal.usda.gov/) o Editorial Boards

Chinese Journal of Physiology, 1994-1997 Journal of Animal Science, 1997-2000 Domestic Animal Endocrinology, 1995-2001, 2011-13 Biology of Reproduction, 2003-present Journal of Biomedicine and Biotechnology

(http://www.hindawi.com/journals/jbb/), 2008-present • Teaching and Mentoring

o Undergraduate Courses ARSC263, Introduction to Animal Biotechnology, 1997-present ARS 323, Fundamentals of Nutrition, 1994-present yearly ARS 463 L, Physiology of Reproduction Laboratory, every year. ARS 491, Undergraduate Seminar; spring semester, 2005; fall

semester, 2004; North Dakota State University, 100% responsibility ARS 463, Physiology of Reproduction; spring semester, 2004;

North Dakota State University, 50% responsibility and coordinator ARS 488, Dairy Production; spring, 2002-2003; North Dakota State

University, 15% responsibility ARS 357, Animal Genetics; spring, 2003; North Dakota State

University, 10% responsibility



ARS 435/635, Nutrition Laboratory Techniques, 1990 – 1998, every other year

Guest Lecturer for senior-level course, ARS 463, Physiology of Reproduction; spring, 2002, 2007; North Dakota State University

Guest Lecturer for senior/graduate-level course, ECE (Electrical and Computer Engineering) 487/687, Cardiovascular Engineering; spring, 2005; North Dakota State University

Guest lecturer in ANSC 220: Livestock Production; Estrous Synchronization in Beef Cattle, 2010

Guest lecturer in ANSC 488: Dairy Industry/Production Management; 2 lectures: Reproduction and Pregnancy in Dairy; Estrous Synchronization in Dairy, 2010

Guest lecturer in ARSC 488: Dairy Industry/Production Management; lectures on mammary gland development and milk synthesis, 2008

Guest lecturer in ARSC 480: Equine Production and Industry; lecture on Equine Reproduction and Reproductive Management, 2007

Guest lecturer in ARSC 736: Techniques in Nutrition; lecture and lab session on the methodology of radioimmunoassay, 2006

Guest lecturer in ARSC 464, Reproductive Management; gave lecture entitled: “Life before Birth: Understanding the Concepts of Fetal Programming,” 2006

Guest lecturer in ARSC 363; Nutrition and Physiology; lecture on exercise physiology, 2006

Guest presentation in ARSC 491: Undergraduate Seminar, “Developmental origins of adult health and productivity: implications for animal production, 2005

Guest lecturer in ARSC 357: Animal Breeding; lecture and lab on transcription and translation; gave lecture on cross-breeding in swine, 2005

Guest lecturer in ARSC 464, Reproductive Management; lecture on research at NDSU, 2004

Guest lecturer in ARSC 488: Dairy Industry/Production Management; lectures on mammary gland development and milk synthesis, 2004-05

Guest Lecturer in ARSC 488: Dairy Industry/Production Management. North Dakota State University; gave lectures on mammary gland development and milk synthesis, 2004

Independent Study – Vonnahme, KA – 12 students, 2005-10 o Graduate Courses

ARS 435/635, Nutrition Laboratory Techniques, 1990 – 1998, every other year

ARS 728, Advanced Reproductive Biology, graduate lecture course; spring semesters, 2002, 2004, 2006, 2008, 2010; North Dakota State University, 100% responsibility



ARS 730, Growth Biology, graduate lecture course; Spring quarter/semesters, 2003, 2005, 2007; North Dakota State University, 100% responsibility

ARS 774, Nitrogen Metabolism 1990 - Present, every other year ARS 775, Vitamins and Minerals, 1998 – Present, every other year. ARS 776, Digestive Physiology, 1989 – 1998, every other year BOT/BIOL/ZOO 720, Advanced Cell Biology, graduate lecture

course; Fall semester, 2007-10; North Dakota State University, 100% responsibility

ARS 598/790, Graduate Seminar; Spring quarter 1987, Spring 2002, 2011; North Dakota State University, 100% responsibility

BIOC 796, Scientific Integrity; Fall semester, 2005-07, 2009-10; North Dakota State University

Guest Lecturer for graduate-level course, ECE (Electrical and Computer Engineering – Bioengineering Focus) 796, ST/Cardiovascular Engineering; Spring 2005; North Dakota State University

9 Future Plans • Research – We plan to expand our current efforts to evaluate various therapeutic

agents (e.g., sildenafil) as well as targeted nutritional supplementation (e.g., metabolizable protein, specific nutrients such as selenium or Arginine) to reverse the effects of poor maternal nutrition and other maternal or fetal factors (e.g., genotype, multiple fetuses, age, etc.) on fetal and offspring growth and health

• National Consortium – We plan to establish a national consortium on Developmental Programming to address and coordinate research, educational, and outreach efforts on this extremely important topic. Initially, we will pursue two avenues to accomplish this goal:

o A NIFA-sponsored regional project to bring together researchers and research groups with an interest in Developmental Programming to establish research, teaching, and outreach priorities

o Multi-agency project – to address funding needs for research, teaching, and outreach efforts in Developmental Programming. This effort will emphasize three priority areas.

Establishment and use of animal models because of their critical importance in solving problems in Developmental Programming;

Collaborative efforts between researchers and livestock producers, with the goal of translating animal-based research to solving problems related to Developmental Programming in livestock

Collaboration between researchers and human nutritionists/clinicians with the goal of translating animal-based research to solving problems related to Developmental Programming in human populations



10 Selected References 1. Wu, G., F. W. Bazer, J. M. Wallace, and T. E. Spencer. 2006. BOARD-INVITED

REVIEW: Intrauterine growth retardation: Implications for the animal sciences. J. Anim. Sci. 84:2316–2337.

2. MacDorman MF, Mathews TJ. 2009. Behind international rankings of infant mortality: How the United States compares with Europe. NCHS Data Brief, CDC (http://www.cdc.gov/nchs/data/databriefs/db23.htm).

3. MOD (March of Dimes), 2009, What’s New: U.S. gets a “D” for preterm birth rate (http://www.marchofdimes.com/peristats/whatsnew.aspx?id=38&dv=wn).

4. WHO, 2005, Feto-maternal nutrition and low birth weight (http://www.who.int/nutrition/topics/feto_maternal/en/index.html).

5. Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993: 341: 938-942.

6. Bell AW. 1992. Foetal growth and its influence on postnatal growth and development. In: The Control of Fat and Lean Deposition. Oxford: Buttwerworth-Heinemann, pp 111-127.

7. Caton, JS and BW Hess. 2010. Maternal plane of nutrition: Impacts on fetal outcomes and postnatal offspring responses. Invited Review. Pages 104-122 in Proc. 4th Grazing Livestock Nutrition Conference. B. W. Hess, T. Delcurto, J. G. P. Bowman, and R. C. Waterman eds. West Sect. Am. Soc. Anim. Sci., Champaign, IL.

8. Godfrey KM, Barker DJ. Fetal nutrition and adult disease. Am J Clin Nutr 2000; 71(5 Suppl): 1344S-52S.

9. Hack M, Klein NK and Taylor HG Long-term developmental outcomes of low birth weight infants. Future Child 1995; 5: 176-196.

10. Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, JS. Luther, CJ Hammer, KR Maddock Carlin, Grazul-Bilska AT and Redmer DA. Developmental programming: The concept, large animal models, and the key role of utero-placental vascular development. J Anim Sci 2010b; 88: E61-E72.

11. Roberts, R. M., G. W. Smith, F. W. Bazer, J. Cibelli, G. E. Seidel Jr., D. E. Bauman, L. P. Reynolds, J. J. Ireland. Policy Forum: Farm Animal Research in Crisis. Science 2009; 324:468-469.

11 Websites http://www.ag.ndsu.edu/cnp/about-cnp 12 Contact Information Lawrence P. (Larry) Reynolds, Ph.D. University Distinguished Professor of Animal Sciences NORTH DAKOTA STATE UNIVERSITY Editor-in-Chief, Animal Science Image Gallery, National Agricultural Library <http://anscigallery.nal.usda.gov/> Hultz 177 NDSU 7630, P.O. Box 6050 Fargo, ND 58108-6050



MY NEW TEL. # 701-231-7641 FAX 701-231-7590 Skype 701-205-4105 mailto:[email protected]

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