Blood based biomarkers

Why do we want them? Exactly what do we want? How will we get it ?

Adapted from Sperling et al (2011) Alzheimer’s and dementia 7 280-92

Why do we want (blood based) biomarkers ?

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1.0

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1.4

1.8

Re

lative

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en

sity P<0.05

0.0 0.2 0.4 0.6 0.8 1.0

1 - Specificity

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Sen

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ROC Curve

Complement Factor H (CFH)

n>500

Proof of a signal in blood

(also complement c4 – decreased)

Biomarkers for prediction

‘Conversion’, progression and sub-type

Companion biomarkers

Specific to target/therapy

Biomarkers for pathology

Discovery by endophenotype

Biomarkers for clinical trials

Stratification and experimental medicine

What, exactly, do we want ?

Biomarkers for AD

not needed, not possible

Correlation with cortical atrophy

Correlation with cognition (MMSE)

Correlation with speed of decline

Design matters

In man….

W/T APP/PS1

In mouse….

European Medical Information Framework

Vision: To enable and conduct novel research

into human health by utilising human health data

at an unprecedented scale

• Access to information on 40 million patients

• Cohorts with samples, imaging and clinical data :

• > 20,000 for dementia and metabolic biomarker discovery and validation

• Linkage of clinical and omics data

• Development of a secure (privacy, legal) modular platform

• Continue to build a network of data sources and relevant research

http://www.imi.europa.eu/content/emif

How will we get biomarkers ?

EMIF – a public private partnership for data-integration

EM

IF -

Meta

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lic

EM

IF -

AD

Data Privacy

Analytical tools

Semantic Integration

Information standards

Data access / mgmt

IMI Structure and Network

Research Topics

EMIF governance

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TBD

EM

IF -

Pla

tfo

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Metabolic CNS

Maudsley BRC

Informatics team

Martina Sattlecker

Steven Kiddle

Steve Newhouse

Anbarasu Lourdasamy

Simon Furney

Gerome Breen

Rob Stewart

Mike Denis

Richard Dobson

King’s College London

Biomarkers team

Abdul Hye

Joanna Riddoch-Contreras

Rufina Leung

Andreas Guentert

Mohammed Aiyaz

Madhav Thambisetty (NIA)

Katie Lunnon

Alison Baird

Nicholas Ashton

Sarah Westwood

Latha Velayudhan

Chantal Bazenet

Angela Hodges

Simon Lovestone

AddNeuroMed

Imaging team

Eric Westman

Sebastian Muehlboeck

Sergi Costafreda

Lars-Olof Wahlund

Christian Spenger

Alan Evans

Andrew Simmons

AddNeuroMed

Clinical team

Hilkka Soininen

Bruno Vellas

Patrizia Meccocci

Magda Tsolaki

Iwona Kłoszewska

Simon Lovestone