amitrityline overdose.pptx1
TRANSCRIPT
A case of cardiac arrest
Dr.Rana Muhammad Habibullah
Intensive Care Medicine
Key content Cardiac arrest secondary to amitriptyline overdose
Management of amitriptyline overdose
Therapeutic hypothermia
Prognostication
Out of Hospital Cardiac Arrest
Witnessed Collapse
No standby CPR instantly
SCDF was called
SCDF arrived in 18 min
Found unresponsive, pulseless
CPR started
Defibrillator attached
ECG Tracing
Out of Hospital Cardiac Arrest
Shock delivered X 2 times
Pulse palpable
Transferred to ED with BMV
Intubated at ED
At EDParameters:
BP 79/52 mm (Hg)
HR 110 bpm
No spontaneous breathing
12 Lead ECG
Summary Survivor of cardiac arrest
Wide complex tachycardia with long QT
What might be cause Cardiac
Drugs
Electrolyte Imbalance
Case HistoryMr.X
53 years/Chinese/Male
Past Medical History
1.Depression
2.Benzodiazepine dependence
Social Issue Married with 3 children
Stays with wife and youngest son
Had behavioural issue and wife had Personal Protection Order
Breached PPO several occasion and had imprisonment
Current Admission Had conflict with wife
Became abusive and violent
Police was called by wife
Patient ingested more than 20 tablets
Police arrived
Patient collapsed while having argument with police
SCDF arrived in 18 minutes
VT arrest No H/O previous cardiac disease/risk factor/symptoms
Normal cardiac enzyme
Electrolytes normal
Diagnosed as VT arrest due to amitriptyline overdose
Issues Amitriptyline overdose
Survivor of cardiac arrest
Amitriptyline Pharmacokinetics:
-Highly lipid soluble
-Bioavailability 30-60%
-Highly protein bound
-Metabolised by liver
-Vd:5-10L/kg
-Half life 31-46 hours
Overdose:Effect CNS:
-drowsiness,coma,seizure,respiratory depression
Cardiovascular
-Tachycardia, Myocardial depression, wide QRS,Long QT,arrhythmia
Others:
Urinary retention, pupillary dilatation
Work up Routine Investigation
Drug screening test
ABG
ECG
ECG in TCA overdose Highly sensitive
Common-sinus tachycardia
Other feature: wide QRS,Long QT, increased PR interval, arrhythmia
Duration of QRS complex-correlates with complication, guide for treatment
R wave in aVr indicates susceptibility to seizure/arrhythmia
Treatment Vital support : ABC
Gastric Decontamination
Activated charcoal
IV sodium bicarbonate
Intralipid
Benzodiazepine for seizure
Treatment at ED IV fluid
IV sodium bicarbonate
Activated charcoal
Post Cardiac Arrest Care Supportive management
Therapeutic Hypothermia
Issues surrounding TH Toxic overdose
Arrhythmogenic drugs
Wide QRS+ Long QT
In ICUPupil :4 mm nonreactive
GCS:3/15
No spontaneous respiration
Gag reflex, cough reflex absent
Day 2
Wife raised concern about unnecessary prolongation of life
Prognostication
American Academy of Neurology guideline
ANN Guideline
Remember H’s and T’s-Cardiac arrest with toxic overdoseDR.RANA MUHAMMAD HABIBULLAH
INTENSIVE CARE MEDICINE
Prognostication Survivor of cardiac arrest
Amitriptyline overdose
Therapeutic hypothermia
Progress: Noted sluggish pupillary reaction D1(evening)
Noted gag reflex on D2
Noted Cough reflex D3
Noted spontaneous respiration D3
GCS was improving
Extubated on D6
Send to GW on D9