Amoebic colitis

Amoebic colitis

• Infection of the colon with Entamoebahistolytica

Morphology

• Sites:

• Ascending colon –the most common

• Sigmoid colon

• Rectum

• appendix

• Flask shaped ulcers:

• Early intestinal lesion is microulceration of mucosa which slowly enlarges.

• Small ulcer with heaped up margin but extends below the surface n apperars as flask-shaped.

• Numerous trophozoites can be seen at the margin of dead n viable tissue.

• Large ulcers show extensive liquefactivenecrosis with shaggy appearance.

• Ameboma: ameobic infection grossly appears as a mass. The mucosa becomes thin n ulcerated.Below this is inflammed n thickened wall of intestine, which is edematous and hemorrhagic with exuberant granulation tissue formation.

• Complications

• 1) liver abscess

• 2) effusion;;pleural

• 3) Hepatobronchial fistula

• 4) pericardial effusion

• Clinical picture:

• Pain abdomen with cramp

• Diarrhoea, sometimes with blood.

• Diagnosis: PAS stain: trophozoites of E.Histolytica are stained by PAS and iron haematoxylin.

• Thank you..