создание апк для генодиагностики атеросклероза
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Diagnostics: Novel Approaches
Institute for Atherosclerosis ResearchSkolkovo Innovative Center, Resident
• activity in business and innovations since 1992• 37 trademarks, licenses, certificates• 4 DSc, 9 PhDs• +700 publications, 8 patents, 15 patent applications• 25 government-funded studies and projects• 57 contracted studies
European Cardiovascular Disease Statistics 2010
Cardiologist
Conclusion-high risk
- medium risk- low risk
Biochemistrycholesterol,
HDL cholesterol,LDL cholesterol,
triglycerides
Current approach
Risk Factorsage,
gender,hypertesion,
smoking,diabetes,
etc.
International Task Force for Prevention of Coronary Heart Disease 2007
risk of infarction or cardiovascular death
3%low
15%intermediate
32%high
8% population
---------------------
15% population
---------------------
77% population
37% infarctions
---------------------
33% infarctions
---------------------
30% infarctions
problem: no adequate methods of individual risk assessment
decision: novel highly informative markers + novel methodology
Software & Hardware Complex
Risk factors &Biochemistry
Physician
Conclusion
UltrasoundGenetics *Genetics *
* Genetic diagnostics: principally novel markers (mutations in mitochondrial genome)
current approach
our decision our is better
Sensitivity ~65% ~90% ~1,4-fold
Specificity ~60% ~85% ~1,4-fold
Accuracy ~60% ~85% ~1,4-fold
Resolution ~40% ~75% ~1,9-fold
Company result of diagnostics * price
Progenika(Spain/USA)
reveal 1 case in 300-500 examinations $500
deCODE Genetics(USA)
reveal 1 case in 40-70 examinations $500
Our decision reveal 1 case in 4-6 examinations $200
* real incidence of predisposal to atherosclerosis, 1 case in 3-4 persons
01.2007 09.2012 12.2015
basic research
clinical and epidemiologic studies
laboratory samples
prototype
verification studies
product development activities
$1.23M
~$9.7M
product optimization
• investments in the project ~$4.8M
• investor’s participation in the form of a contribution to share capital and/or
contribution to the property
• sale of shares when the estimated volume of sales and/or capitalization
level is achieved
• exclusive license (for profiled investor)
EXECUTIVE SUMMARY
problem: no adequate methods of individual risk assessment
decision: novel highly informative markers + novel methodology
product: diagnostic kits + hardware & software complex for data interpretation
competitive advantages: no direct analogues, innovative methodology, IP as EU patent and patent applications, unbeaten diagnostic value; quantitative estimates
market size: up to 50M potential end users in Russia; obvious perspectives for global markets
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