1 o 2 + fa oh ° + fa ° singlet oxygen hydroxyl radical pufa + oh ° pufa ° + h 2 o pufa radical...
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1O2 + FA OH° + FA° Singlet Oxygen Hydroxyl Radical
PUFA + OH° PUFA° + H2O PUFA Radical
PUFA° + O2 PUFAO2°
PUFA Peroxide Radical
PUFAO2° + PUFA PUFAO2H + PUFA° Lipid Hydroperoxide
Breakdown Products (toxic)
Lipid Peroxidation
Factors influencing LPOin parenteral lipid admixtures
Oxygen
(Ambient) Light
Temperature
Micronutrients
Trace elements (Cu, Fe, Se)
Vitamins (E, A, C)
0
1
2
3
4
1 4 8 14 19 29
days of storage
peroxide values[mmol peroxides/L]
0.8
20-30°C / daylight; with TE20-30°C / daylight 2-8°C / light-protected with TE 2-8°C / light-protected
Steger, Mühlebach JPEN 2000;24:37-41
Lipid peroxidation of AIO admixtures:Influence of trace elements (TE) and storage conditions
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