1,000 compounds 15 hits - perkinelmer...breast cancer is influenced by signaling pathways in the...
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3D CELL CULTURE IS CHANGING THE GAME.The research tool can show a more biologically relevant picture of how cells function on many levels.
3D BY THE NUMBERSThe number of publications using 3D cell culture has nearly tripled over the past 5 years.
THE DEMAND FOR 3D CELL CULTUREBecause of these benefits, the 3D cell culture market is expected to more than triple in size by 2024.
3D MODELING: FLASHBACK TO THE 80SIn the 1980s, the Bissell lab began using 3D cell models to study how breast cancer is influenced by signaling pathways in the tumor microenvironment.
DRUG DISCOVERY IN ACTIONIn a recent study, a 3D organotypic model of ovarian cancer identified smaller molecules that inhibited ovarian cancer cell adhesion, migration and invasion. Out of 1,000 compounds screened, 15 were active hits.
WHY USE 3D OVER 2D?3D organotypic culture models (such as organoids and spheroids) are better than 2D models because they:
ü create cellular interactions that mimic scenarios in vivo;
ü exhibit a higher degree of structural complexity and homeostasis, similar to tissues and organs; and
ü provide accurate predictions of drug efficacy and toxicity, along with an understanding of a drug’s mechanism of action.
VISUALIZE THE FULL DETAIL OF 3D CELL CULTURE WITH HIGH CONTENT ANALYSIS
PerkinElmer offers a full product portfolio for 3D applications that includes spheroid culture platforms, reagents for metabolic analysis, and premier high
content analysis and screening imaging platforms.
Study the cell’s vascular system
Learn how cells
communicate and interact
with each other
Avoid sacrificing animals for models in preclinical studies
See how cells migrate, differentiate, survive
and grow
Source: Grand View Research, Inc.
perkinelmer.com/3Danalysis
Observe phenotypic
changes in detail
THE KEYS TO 3D
3D CELL CULTURE: COMING TO A LAB NEAR YOU
1,000 compounds15 hits
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1400
1630
2011 2012 2013 2014 2015
CORE BENEFITSThey also allow researchers to:
2013
Cancer
500
1000
US
D m
illio
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1500
2000
2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Tissue engineering & immunohistochemistry
Drug development
Stem cell research
Others
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