4.topical astringents

Pankaj Kusum Ramdas KhuspeM. Pharmacy (Pharmaceutics)

“Brings about protein precipitation.”

E.g.: Alum

Uses

For Styptic action

Anti inflammatory

Anti perspirant

Anti microbial

To remove unwanted skin

Alum

KAlSO4 .12H2O

MOP:1. From Alunite or bauxite

2. By mixing conc. potassium sulphate to aluminum sulphate

Physical Properties:

• Colorless granular crystalline powder

• Odourless

• Sweet astringent taste

• soluble in water

• Soluble in glycerin

• Insoluble in alcohol

• Aqueous solution is acidic in nature

Uses

• Topical agent

• Astringents

• Preparation of toxoids

• Antiseptics

• Local styptic action

Storage

“ It should be stored in well closed container at a cool

place.”

Zinc sulphate

ZnSO4MOP:1) By heating zinc sulphate in air

ZnS + 2O2 ZnSO4

2) Mixing zinc with sulphuric acidZn + H2SO4 ZnSO4 + H2

Physical Properties:

• Colorless powder• Odorless• Astringent taste• Very soluble in water• Very soluble in glycerin• Insoluble in alcohol• Aqueous solution is acidic in nature

Chemical Properties

When it is strongly heated it decomposes

Uses

• Topical agent• Astringents• Mild germicidal• Emetic• Local styptic action• Preparation of bandages and adhesive

tapes

Storage

“ It should be stored in well closed container at a cool

place.”