a safer approach to chronic pain management tom wroth md, mph jerry mckee pharm.d., m.s., bcpp...

A Safer Approach to Chronic Pain Management

Tom Wroth MD, MPH

Jerry McKee Pharm.D., M.S., BCPP

NCCHCA Annual Conference

Asheville, NC

June 23, 2012

Objectives

At the completion of this discussion, attendees will be able to •Understand the need for practices to approach chronic pain management in a systematic way•Understand the scope and clinical significance of chronic pain management issues nationally and in North Carolina•Describe the CCNC chronic pain initiative and its goals•Relate how specific practice level interventions can successfully and appropriately address the needs of chronic pain patients

Chronic Pain

• Chronic pain is defined as persistent pain, which can be either continuous or recurrent and of sufficient duration and intensity to adversely affect a patient's well-being, level of function, and quality of life.(Wisconsin Medical Society Task Force on Pain Mgt, 2004)

Why Should Health Centers Focus on Chronic Pain?

• Common medical problem in the community

– ~10% of adults

– Leads to significant disability

• Increased prevalence in health center populations (Medicaid, Medicare, Uninsured)

• Co-morbid chronic conditions: DM, CAD, HTN, Depression

• Changing epidemiology of accidental overdose

Why Should Health Centers Focus on Chronic Pain?

• Source of burnout and frustration for providers and staff

• Source or RISK for practices– Medical licensure and privileging– Medico-legal risk: accidental overdose

• We are a Patient Centered Medical Home– Team based care– Collaborative care model

The Challenge: There is not enough time…

With a typical panel of primary care patients-

•10.6 hours per day for chronic disease care

•7.4 hours per day for preventive care

•4.6 hours per day for acute care

Chronic pain management requires time and teamwork

Challenges: Clinicians can Foster Misuse

• Confrontation phobia– Fear of damaging physician-patient

relationship– Trouble saying “No”– Not skilled in discussing addiction

• Enabling behaviors– Physicians desire to relieve distress/pain

Chronic Pain and Co-Morbidities

• Depression – Prevalence of 35-50%• Anxiety – increased prevalence

– Associated with avoidant coping pattern

• Substance abuse – increased prevalence• Sleep Disorders

– Lack of restorative sleep perpetuates chronic pain and reduces function

• Personality disorders• Hx of childhood abuse

Definitions Misuse-use for purpose other than intended (get

high) Abuse- harmful use of a drug (drinking and

driving) Tolerance-body adapts to a certain dose such

that more is needed to achieve the same effect Physical Dependance- withdrawal occurs when

substance is stopped Addiction-behavioral term- denotes psychological

dependence, compulsive use, for reasons other than therapeutic use

How Prevalent is Misuse?

Total Pain Population

Aberrant behavior 40%Abuse 20%

Addiction 2-5%

US Prescription Overdoses

CDC Vital Statistics, Nov 2011•15,000 deaths annually

•In 2010, 1 in 20 used pain killers for nonmedical purposes

•Enough prescription painkillers were prescribed in 2010 to medicate every American adult around-the-clock for a month.

Drug overdose death rate --- United States, 2008

Source: Len Paulozzi, CDC Nov. 2011

0

2,000

4,000

6,000

8,000

10,000

12,000

14,000

'99 '00 '01 '02 '03 '04 '05 '06 '07

De

ath

s

14

Unintentional Overdose Deaths Involving Opioid Analgesics, Cocaine and Heroin

United States, 1999–2007Opioid analgesic

Cocaine

Heroin

National Vital Statistics System, http://wonder.cdc.gov, multiple cause dataset

Year

Source: Len Paulozzi, CDC Nov. 2011

Unintentional drug overdose death rates and total sales of opioid analgesics in morphine

equivalents by year in the U.S.

012345678

'90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07

0100200300400500600700800

Deaths/100,000 Opioid sales (mg/person)

Source: Len Paulozzi, CDC Nov. 2011

North Carolina Poisonings

Source: NC State Center for Health Statistics, Death file 2010; Analysis by Injury Epidemiology and Surveillance Unit

147

183

536

854

855

947

1,160

1,301

Leading Causes of Injury Deaths (by Number of Deaths, All Ages, North Carolina Residents: 2010)

Unintentional Motor Vehicle Crashes

Suicides

Unintentional Poisoning

Unintentional Falls

Homicides

Unintentional Suffocation

Unintentional Drowning Total Deaths = 5,983

* Unintentional Other and Unintentional Unspecified are two separate categories. Other comprises several smaller defined causes of death, while Unspecified refers to unintentional deaths that were not categorized due to coding challenges.

Unintentional, Other & Unspecified*

Unintentional Poisoning Deaths by County: N.C., 1999-2009

Source: N.C. State Center for Health Statistics, Vital Statistics-Deaths, 1999-2009Analysis by Injury Epidemiology and Surveillance Unit

Source: Farhad Modarai¹, Karin Mack¹, Leonard Paulozzi¹, Scott K. Proescholdbell²

Data Source: ARCOS Data

Mortality Rates of Unintentional and Undetermined Opioid Overdoses and Dispensation Rates of Opioid Analgesics*: North Carolina Residents, 2009

*Source:Mortality data: State Center for Health Statistics, NC Division of Public Health, 2009Population data: National Center for Health Statistics, 2009Prescription dispensation data: Controlled Substances Reporting System, 2009

Analysis:KJ Harmon, Injury Epidemiology and Surveillance Unit, Injury and Violence Prevention Branch,, NC Division of Public Health

Number of Times in which a Drug was Mentioned as a Cause of Death: N.C., 2010*

Source: N.C. State Center for Health Statistics, Vital Statistics-Deaths, 2010Analysis by Injury Epidemiology and Surveillance Unit

*Categories are not mutually exclusive

†Includes licit drugs that are misused/abused

0

200

400

600

800

1000

1200

1400

Total Illicit Licit†

All Drugs 100%

Cocaine, 12%

Heroin, 3%

Other Synthetic Opioids, 14%

Methodone, 16%

Other Drugs, 26%

Other Opioids, 36%

By combining prescription records with toxicology data, we were able to get an idea of how many cases had a prescription for the drug(s) that contributed to their death.

Combining CSRS and OCME data

Number of cases

Deaths per drug

Chronic Pain Initiative

CCNC and Project Lazarus:

Chronic Pain and Community Initiative

A set of inter-related programs designed to improve the medical care

received by chronic pain patients, and in the process, to reduce the

misuse, abuse, potential for diversion and overdose from opioid

medication.

Key program components:

Clinical Community Focus

Primary Care Physician Toolkit Take only your own medications

Emergency Department Toolkit Keep medications in a safe place

Care Management Toolkit Education on dangers of opioids

Network CPI Champion

What is the Chronic Pain Initiative?

Model is based on proper assessment, diagnosis, and treatment plan with Pain agreement as necessary

Community Care of North Carolina (CCNC), in conjunction with non-profit organization Project

Lazarus, is responding to some of the highest drug overdose death rates in the country through its

Chronic Pain Initiative (CPI).

Goals

Reduce opioid-related overdoses

Optimize treatment of chronic pain

Manage substance abuse issues (opioids)

Project Lazarus/Chronic Pain Initiative Model

Community Awareness

Epidemiologic Surveillance

Overdose Prevention

and Diversion Control

Program Evaluation

Overdose Rescue

Source: Wilkes Co. Health Department; NC SCHS; CDC Wonder

Project Lazarus. First Site – Wilkes County. Accidental poisoning deaths decrease

by more than 65% after start-up

Wilkes Recipients of Opioids*: As deaths go down, patients continue to get their pain medication

Source: NC CSRS and Project Lazarus

Project Lazarus Expands: in 2012 joins North Carolina’s Medicaid Authority (CCNC)

for statewide implementation

Project Lazarus – Strategies to community coalitions

Chronic Pain Initiative – Strategies to health care providers

Community awareness Provider education

Coalition formation and development ED policy change

Diversion control Expanded access to drug treatment

Pain patient support Patient risk reduction

Why are we looking at replication?

Cost of Hospitalizations for Unintentional Poisonings: NC, 2008

Average cost of inpatient hospitalizations

for an opioid poisoning*: $16,970. Number of hospitalizations for unintentional

and undetermined intent poisonings**: 5,833

Estimated costs in 2008:

$98,986,010

Does not include costs for hospitalized substance abuse*Agency for Healthcare Research and Quality** NC State Center for Health Statistics, data analyzed and prepared by K.

Harmon, Injury and Violence Prevention Branch, DPH, 01_19_2011Prepared by Project Lazarus through an unrestricted educational grant from Purdue Pharma LP: NED101356

Key Ingredients in Chronic Pain Initiative

Establishment (or prior existence) of a community coalition that is able to develop and implement effective strategies to reduce substance use

A sense of urgency among local actors who have influence

Dedicated manager of the coalition with skills in process and content

Appropriate strategy for achieving a change in prevailing medical practice re: treatment of chronic pain patients (PCP and ED locations)

Tailored to local conditions

Includes education on the extent of the problem in the community and the role of providers in limiting supply and opportunities for diversion

Includes useful tools that providers can adopt (e.g., Medication Agreements, guidelines for proper script writing)

Explicit recommendations for hospital policies that limit dispensing of narcotics (especially to ED patients)

Take advantage of leverage points in larger environment (e.g., CSRS, Medicaid lock-in policy)

Key Ingredients in Chronic Pain Initiative

Makes effective use of various partners in carrying out strategies including but not limited to:

Public health department – multiple strategies

County Medical Director – to reach physicians and ED

Medical providers – to change their own practice and educate other providers

Pharmacist – to other pharmacies in community

Law enforcement

Schools

Behavioral Health, Prevention and Treatment Programs and Organizations

Can coalitions help reduce Rx drug abuse?

Counties with coalitions had 6.2% lower rate of ED visits for substance abuse than counties with no coalitions (but this could be due to random chance)

However, counties with a coalition where the health department was the lead agency had a statistically significant 23% lower rate of ED visits (X2=2.15, p=0.03) than other counties

In counties with coalitions 1.7% more residents received opioids than in counties without a coalition.

Coalitions may be useful in reducing the harms of Rx drug abuse while improving access to pain medications at the same time.

More professional coalitions may have a greater impact on reducing Rx drug harms.

Data Sources: NC Health Directors Survey, NC DETECT (2010), CSRS (2008-2010)

Contents of the Toolkit

General information

Managing chronic pain

Proper prescription writing

Precautions

Tools for managing chronic pain patients

Universal Precaution for Prescribing and Algorithm for assessing and managing pain

Pain Treatment Agreement

Format for progress notes

Medication flowsheet

Personal care plan

Prescriber and Patient education materials

Screening Forms and Brief Intervention

Naloxone Prescribing

Controlled Substance Reporting System (CSRS)

Primary Care Tool Kit

• Physician toolkit for treating chronic pain patients

• Encourage the use of Pain Treatment Agreements with chronic pain

patients

• Encourage use of Provider Portal

• Encourage use of Controlled Substance Reporting System (CSRS)

• Encourage the assignment of pharmacy home for chronic pain patients-

lock-in program

Emergency Department Tool Kit

• Care management for pain patients visiting ED

• ED policy that restricts the dispensing of narcotics

• Encourage the Use of the CSRS by ED physicians

• Encourage the Use of Provider Portal in the ED

• Identify Chronic Pain Patients and Refer for Care Coordination based

on ED assessment

Care Management Tool Kit

Provide support to ED identification of chronic pain patients- referrals to PCP or specialty services

Provide care management for patients identified by PCP practice as CPI patient; consider pharmacy lock-in program

Ongoing care management for Medicaid patients with narcotic prescriptions above threshold pain patients via TREO data

Educate PCPs and providers in utilization of Chronic Pain Tool Kit

Emergency DepartmentPolicy

Non-narcotic pain medication for “frequent fliers.”

Prescriptions for narcotic or sedating medications that have been lost, stolen or expired will not be refilled in the Emergency Department

Referrals to Primary Care Providers Accepting New Patients.

Prescriptions necessary only in limited quantities North Carolina Controlled Substances Reporting

System, checked for any prescription for a controlled substance

Contact

Dr. Mike Lancaster mlancaster@n3cn.org

Fred Wells Brason II fbrason@projectlazarus.org

www.communitycarenc.org

www.projectlazarus.org

Controlled Substance Reporting System (CSRS)

Controlled Substances Reporting System NCGS 90-113.70-76

• Passed in August 2005

• Reporting began July 2007

• Required all dispensers to report to a centralized data base

• Weekly reporting began 01/02/10

CSRS Data Overview

• Over 84,000,000 prescriptions in the database (started July 1, 2007)

• Approx. 17.5 million per year

• Over 2,750,000 queries have been made of the system

• Over 11,300 dispensers and practitioners currently registered to use the system

• Averaging 2,300 queries per day

Top 10 Controlled Substances Dispensed in North Carolina: Number of Prescriptions, CSRS 2010

Source: Preliminary data: NC Controlled Substances Reporting System, Nov. 2011

571,192

613,350

671,662

705,301

847,974

1,097,151

1,604,778

1,757,764

2,451,678

4,302,868

0 500,000 1,000,000 1,500,000 2,000,000 2,500,000 3,000,000 3,500,000 4,000,000 4,500,000 5,000,000

DIAZEPAM

PROPOXYPHENE

AMPHETAMINES

METHYLPHENIDATE

LORAZEPAM

BENZODIAZEPAM

ZOLPIDEM

ALPRAZOLAM

OXYCODONE

HYDROCODONE

Doctor Shopping*: Trends for Schedule II

Patients with Multiple Prescribers and Dispensers Source: NC CSRS*Based on number of prescribers AND number of pharmacies within each 6 month period for schedule II.

How to contact the CSRS• www.nccsrs.org

• Call Bill Bronson, John Womble, or Devon Scott

919.733.1765• E-mail

William.Bronson@dhhs.nc.gov

Johnny.Womble@dhhs.nc.gov

Devon.Scott@dhhs.nc.gov

Step-by-Step Approach to Improving Chronic Pain

Management

Principles of Chronic Disease Management

• Use clinical information systems to Identify the population

• Identify best practices and develop practice guidelines

• Create team based approach with defined roles

• Define measures that will reflect performance improvement and report back to team

• Develop tools to support self management

Step 1: Use Information Systems to Identify the

Population• Use EMR or practice management software

query to identify the number of patients with chronic pain– Chronic Pain Syndrome – 338.4, back pain,

headache, neck pain, fibromyalgia *ICSI Guideline

– Encourage providers to code 338.4 in addition to specific diagnosis

– Look at # patients per provider or practice to identify your hot spots

Identify the Population:

Chronic Pain on Problem List

One Center has a high prevalence of opioid prescribing

Step 2: Identify Best Practices

• Start a workgroup with a clinical champion

• Identify practice guidelines– North Carolina Medical Board– Institute for Clinical Systems Improvement– Specialty societies: AAFP– Washington Medical Directors Group

The NC Medical Board

• Position statement 2008• 2010: 30% of NCMB infractions were due to improper

prescribing• Medical board advises:

– Clear documentation of history and physical, review of records, documentation of prescriptions, response to treatment, clear indication for treatment

– Use of practice safeguards (contracts, UDS, CSRS)– Identifying high risk patients and referring as

necessary (pain management or substance abuse)– Identifying “red flags”

Guidelines

• Institute for Clinical Systems Improvement (ICSI)– Healthcare Guideline: Assessment and

Management of Chronic Pain, 2011

• Washington State Medical Directors: – Interagency Guidelines on Opioid Dosing for

Chronic Pain, 2010

• American Pain Society– Guidelines for the Use of Opioid Therapy in

Patients with Chronic Pain, 2009

Step 2: Identify Best Practices

• Assessment:– Functional assessment- SF-36– Risk for Misuse

• Opioid Risk Tool• DIRE, COMM, SOAP• Baseline Urine Drug Screen• NC Controlled Substance Reporting System• Department of Corrections Website

– Depression and Substance Abuse Screen• PHQ9, CAGE

Decision Support

Risk Assessment, Depression Screen,NC CSRS, UDS, Pain Contract

Step 2: Identify Best Practices

• Management– Treatment agreement– Safe opioid prescribing

• < 100 mg MED, Drug combinations

– Monitoring High Risk Patients• Urine Drug Screen• NC CSRS

– Guidelines for referral to • Pain management• Substance Abuse• Mental Health

“Rational Prescribing Practices”

Framework for prescribing medications with abuse potential

•Have a clear clinical indication

•Assess risk using validated tools

•Establish therapeutic agreement

•Monitor and assess regularly

•Document appropriately

•Be willing to interveneFlinch JW, Prmary Care Clinics of N America, 1993

Step 3: Create a “Care Pathway” that Uses a Team

Based Care Approach• Provider

– Code Chronic Pain 338.4– Excellent documentation of assessment and

management– Management decisions

• Start, Continue, or Stop opioids

• Referral

• Safe opioid prescribing

– Identify high risk patients for monitoring

Step 3: Care Pathway

• Nursing:– Obtain Urine Drug Screen at defined intervals– PHQ9, Functional Assessment Tool

• Nursing/Care Management/Pharmacy– Opioid Risk Tool– NC CSRS report to provider (must be done by

pharmacist or provider)– Department of Corrections report to provider

• Quality/Administration: Quality data reporting and feedback

Use Tools to Identify Gaps in Care

Decision Support:‘What needs to be done’

Step 3: Define measures that will reflect performance improvement and report back

to team

• How do you know if you are improving care?– % patients on opioids with risk assesment

(ORT or PHQ9)– % patients on opioids with pain management

agreement– % patients on opioids with Urine Drug Screen

in 12 months

Incorporate Pain Measures into Quality Plan

% Patients with Contract

Step 4: Self Management Support

Step 5: Collaborate with Community Partners

• “It takes a village to take care of a chronic pain population’’– CCNC Chronic Pain Initiative

• Use medical management committee to develop common guidelines

• Use CCNC care managers as referral source• Meet with ER Physicians• Identify suboxone providers• Project Lazarus: Naloxone rescue initiative

Step 6: Collaborate with Pain Management Specialists

• Identify specialists in your area

• Share your guidelines for assessment, management, and referral

• Develop consultation relationships where information can be shared on high risk patients

PHS Pain Management Specialty Clinic

• 7 month experience with integrated pain management specialist– ½ day every 2 weeks – Internal referrals of high risk patients with specific

management questions– Goal of consultation

• Increase capacity of primary care provider to care for chronic pain patients

• Develop management plan

• Identify patients that would benefit from procedures or other referrals

PHS Pain Management Specialty Clinic

• Preliminary Results:– 46 patients with average of 2.9 visits– Structured assessment and management

protocols with care management support– Improved confidence and capacity in practice– Improved utilization of pain contracts,

assessment tools– Decreased risk associated with aberrant

patient behaviors

PHS Pain Management Specialty Clinic

• Functional assessment– Baseline SF-36 = 28.9– Mean increase = 3.7

• Depression– Mean PHQ9 = 12– Mean change in PHQ 9 score = -5

• Risk assessment– % with CSRS issue = 4.3%– % with unexpected findings on UDS = 32.6%

Conclusions

There is a public health need for practices to improve management of chronic pain

Team based care and care pathways can help providers improve care

Practices should collaborate with community partners and specialists to help manage the population

76

Questions?