acs-nsqip procedure targeted variables: liver …web2.facs.org/download/aloia_2.pdffinalists: top 12...

ACS-NSQIP Procedure Targeted Variables:Liver ResectionThomas A. Aloia, MD, FACSSurgeon Champion

Goals of the Session

• Examine the History of PTVs in Liver Surgery

• Discuss proposed PTVs• Additions• Subtractions• Conclude with ~8-12 finalists

History

• Proposed by Tim Pawlik and Steven Strasberg in 2009– No progress

• Genesis of this session topic– Henry Pitt

• IHPBA 2012

• NSQIP PUF 2005-2010– 1.2 million cases– 7,500 Hepatectomies

Crucible

• Must not duplicate current collected data• Must directly impact a specific 30-day outcome

– Transfusion– Bile Leak– Length of Stay– Liver Insufficiency– Morbidity– Mortality

• Improve risk adjustment– Redo

• Must be instrumental in answering a major question in the field– GA + Epidural vs GA only

• Binary if at all possible• Collectable by SCRs

– Must have an accepted definition– Available in common documentation (?Path report)

Focus on Major Questions

• Anesthesia• Chemotoxicity/Cirrhosis• Resection risk adjustment

– Redo, staged, multivisceral• Approach

– MIS vs Open• Important postoperative occurrences

– Bile leak– Liver insufficiency

Herding Cats

Proposed Hepatectomy Variables

• Preop biliary stent • Other therapy • Preop creatinine level• Preop INR • Preop bilirubin level • Platelet count • Viral hepatitis • Liver texture • Number of concurrent partial

resections / wedges performed at time of surgery

• Concurrent intra-operative ablation

• Inflow occlusion (Pringle maneuver) during resection

• Biliary reconstruction

• Drain(s) left at conclusion of procedure

• Primary Diagnosis • If neoplasm, tumor size (largest

dimension)• If neoplasm, number of discrete

tumors • Positive margins • Need for invasive intervention

postoperatively (not counting reoperation)

• Peak post-operative INR (between postop day 3 and discharge/death)

• Peak post-operative bilirubin (between postop day 3 and discharge/death)

Proposed Hepatectomy Variables

• Preop biliary stent • Other therapy • Preop creatinine level• Preop INR • Preop bilirubin level • Platelet count • Viral hepatitis • Liver texture • Number of concurrent partial

resections / wedges performed at time of surgery

• Concurrent intra-operative ablation

• Inflow occlusion (Pringle maneuver) during resection

• Biliary reconstruction

• Drain(s) left at conclusion of procedure

• Primary Diagnosis • If neoplasm, tumor size (largest

dimension)• If neoplasm, number of discrete

tumors • Positive margins • Need for invasive intervention

postoperatively (not counting reoperation)

• Peak post-operative INR (between postop day 3 and discharge/death)

• Peak post-operative bilirubin (between postop day 3 and discharge/death)

Quarterfinalists

• Other Therapy (PVE)• Preop biliary stent • Liver texture • Number of concurrent

partial resections / wedges performed at time of surgery

• Concurrent intra-operative ablation

• Inflow occlusion (Pringle maneuver) during resection

• Drain(s) left at conclusion of procedure

• Primary Diagnosis • Peak INR and Bili

Additions?

• Anesthesia• Post operative bile leak• Approach

Semifinalists

• Preop Risk Factors– PVE– Biliary stent– Histology

• Intraop Variables– Anesthesia– Approach– Character of the liver– Magnitude of the procedure– Duration of inflow occlusion– Hemostatics and Drains

• Postoperative Occurrences– Liver insufficiency– Bile leak

Individual Review

• Objective data• Institutional experience• NSQIP experience

PVE

Pros• Direct link to postop

outcome: liver insufficiency

Cons• Uncommon

– <10%

PVE

• Proposal– Include Yes/No

Preop Biliary Stent

Pros• Direct link to postop

outcome: infection and liver insufficiency

Cons• Rare

– <5%– Likely accounted for by

Other CPT coding of hepatico-enterostomy

Preop Biliary Stent

• Proposal– Exclude

Histology

Pros• Malignant vs benign

and type of malignancy impact technique/magnitude of resection/loss of viable parenchyma

• Help classify MIS utilization

Cons• Unlikely to impact 30-

day outcomes independent of magnitude of resection

• Already partially present in ICD-9/10 coding

Histology

• Proposal– Exclude

Anesthesia

Pros• Important question in

our field• Novel techniques

emerging

Cons• None• Current NSQIP variable

may be changed

Anesthesia

• Proposal– Push for all of NSQIP to code as:

• GA Only• Regional Only• Local Only• GA + Regional

– If unsuccessful:• GA only vs. GA + Regional

Approach

Pros• Becoming more

common• Not well captured by

CPTs

Cons• None

Approach

• Proposal– Include as the final approach

• Robotic• Total Lap• Hybrid• Open

– Do not include conversion• Stigma of conversion is a threat to patient

safety

Character of the Liver

Pros• Vital information

regarding risk of liver insufficiency

Cons• Gross and microscopic

component do not always correlate

• Chemotoxicity in several forms

• Steatosis• Cirrhosis w/wo portal

hypertension

Character of the Liver

• Proposal– Include– Cirrhosis

• Absent• Present without Portal HTN• Present with Portal HTN

– Gross Steatosis (Y/N)– Gross Chemotoxicity (Y/N)

Magnitude of the Procedure

Pros• Critical predictor for

multiple postop occurrences

Cons• How to measure

beyond CPT• CPT coding weakest

with multifocal resection strategies– RH + PLH

• Redo

Magnitude of the Procedure

• Proposal– Add Bilateral Resection/Ablation– Add Redo

Duration of Inflow Occlusion

Pros• Appropriate/inappropria

te use may influence EBL/Transfusions/liver insufficiency

Cons• Duration is key variable

and easy to collect but is not the whole story– Application before vs

after bleeding– Off pringle times

Duration of Inflow Occlusion

• Proposal– Total minutes of occlusion

Hemostatics and Drains

Pros• Possible relationship

with bleeding/bile leak/infection/LOS

• Very good randomized data indicating that hemostatics raise cost and have no impact on outcome

Cons• None for drains• How to classify

hemostatics– Materials vs sealants– Amount

Hemostatics and Drains

• Proposal– Exclude hemostatics– Include: Drain Yes/No

Liver Insufficiency

Pros• Likely our most

important procedure specific morbidity/mortality

Cons• Which definition

Liver Insufficiency

• Proposal– Peak INR and Bilirubin

Bile Leak

Pros• Likely our second most

important procedure specific morbidity/mortality

• Not completely accounted for by “deep space infection”

Cons• How to define?

Bile Leak

• Proposal– Include– Define: Abdominal fluid output containing

bili>2x serum bili requiring prolonged preliminary drainage (>POD4) or placement of secondary drain

Finalists: Top 12

• PVE– Y/N

• Anesthesia– GA only vs. GA + Regional

• Approach– Robot, TL, Hybrid, Open

• Character of the liver– Cirrhosis

• Absent• Present without Portal HTN• Present with Portal HTN

– Gross Steatosis (Y/N)– Gross Chemotoxicity (Y/N)

• Magnitude of the

procedure– Bilateral

Resection/Ablation (Y/N)– Redo (Y/N)

• Duration of inflow occlusion– Total minutes of occlusion

• Drains– Drain Y/N

• Liver insufficiency– Peak Postop INR and

Bilirubin• Bile leak

– Y/N

Summary of DropoutsVariable Reason

Preop creatinine level Already collected

Preop INR  Already collected as coagulopathy

Preop bilirubin level  Already collected

Platelet count  Already collected

Viral hepatitis  Not relevant to 30‐day outcomes, included in cirrhosis

Biliary reconstruction  Already collected as an ‘Other CPT’

If neoplasm, tumor size (largest dimension) Not relevant to 30‐day outcomes, included in CPT, HTF

If neoplasm, number of discrete tumors  Not relevant to 30‐day outcomes, included in CPT, HTF

Positive margins  Not relevant to 30‐day outcomes, HTF

Need for invasive intervention postoperatively Included in bile leak variable and deep space infection

Preop biliary stent Accounted for by ‘Other CPT’, HTF

Hemostatics Proven to have no benefit

Histology Not relevant to 30‐day outcomes, included in ICD‐9, HTF

Finalists: Top 12

• PVE– Y/N

• Anesthesia– GA only vs. GA + Regional

• Approach– Robot, TL, Hybrid, Open

• Character of the liver– Cirrhosis

• Absent• Present without Portal HTN• Present with Portal HTN

– Gross Steatosis (Y/N)– Gross Chemotoxicity (Y/N)

• Magnitude of the

procedure– Bilateral

Resection/Ablation (Y/N)– Redo (Y/N)

• Duration of inflow occlusion– Total minutes of occlusion

• Drains– Drain Y/N

• Liver insufficiency– Peak Postop INR and

Bilirubin• Bile leak

– Y/N

Successful Implementation=?

• Ability to answer…– PVE prevalence and impact?– When is Epidural positive/negative?– Impact of cirrhosis/steatosis/chemotoxicity on

outcomes?– Improved accuracy of risk adjustment based

on magnitude of procedure?– When is pringle positive/negative?– Do drains increase infections?– Know the risk factors for bile leak and LI?