analytical and process equipment
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K1 Competence Center - Initiated by the Federal Ministry of Transport, Innovation and Technology (BMVIT). and the Federal Ministry of Economy, Family and Youth (BMWFJ)Funded by the Austrian Research Promotion Agency (FFG), Land Steiermark and the
Styrian Business Promotion Agency (SFG).
Analytical and Process Equipment
Research Center Pharmaceutical Engineering GmbH (RCPE)
July 2013
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Overview Analytical Services I
19.04.2023RCPE Overview Services
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AttributeMeasurement
PrincipleMeasurement Device
Particle Size Laser Diffraction HELOS KR (Sympatec)
Particle Size Laser Diffraction Mastersizer 2000 (Malvern)
Particle Size & ShapeDynamic Picture
Analysis QICPIC (Sympatec)
Particle SizeDynamic Light
ScatteringNano ZS (Malvern)
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Overview Analytical Services II
AttributeMeasurement
PrincipleMeasurement Device
DensityGas Pressure
DifferentialAccuPyc 1340 Helium
Pyknometer (Micromeritics)
(Compacted) Bulk DensityVolume Change of Bulk
PowderPT-TD200 (Pharmatest)
Flow Properties / Fluidisation Segregation / Cohesion / Friction Angle
Normal Force, Shear Strength and Torque
FT4 Powder Rheometer System (FreemanTechnology)
Particle Size and Shape in Fluid Dispersion
Flow-Through Microscopy
MFI 5100 (Protein Simple)
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Overview Analytical Services III
19.04.2023RCPE Overview Services
4
AttributeMeasurement
PrincipleMeasurement Device
Zeta PotentialLaser Doppler Micro-
ElectrophoresisNano ZS (Malvern)
Dissolution Rate / in vitro Drug Release Information
Dissolution Apparatus USP 1 (Basket) and
USP 2 (Paddle) / UV Spectrophotometer
DT820LH (Erweka) + UV/ViS Lambda 25
(Perkin Elmer)
FriabilityExposure of Tablets to Mechanical Shock and
Attrition
PTF10E(PharmaTest)
Density / Velocity of Sound
Oscillating U-tube Sensor
DSA 5000 M (Anton Paar)
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Overview Analytical Services IV
19.04.2023RCPE Overview Services
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AttributeMeasurement
PrincipleMeasurement Device
Specific Surface / Porosity
Gas Adsorption Krypton / Nitrogen,
BET (Brunauer–Emmett–Teller) theory
Tristar II 3020 (Micromeritics)
Specific Surface / Porosity
Gas Adsorption Nitrogen,
BET (Brunauer–Emmett–Teller) theory
ASAP 2000(Micromeritics)
Structure / Polymorphism / Inner Surface
Small and Wide Angle X-Ray Scattering
(SWAXS)
S3-Micro SWAXS (Hecus/Bruker)
Secondary Protein Structure / Extruder
Residence Time
Raman Scattering (Flexible Process
Probe)
RXN2 Hybrid
(Kaiser Optics)
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Overview Analytical Services V
19.04.2023RCPE Overview Services
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AttributeMeasurement
PrincipleMeasurement Device
Concentration /Enzyme Kinetics
UV/VIS Spectroscopy (Transmission,
Absorption)
Lambda 950 (Perkin Elmer)
Concentration / Reaction Kinetics
Fourier Transform IR/Near-IR
Spectroscopy (Transmission,
Absorption, Diffuse Reflection)
Spectrum 400 (PerkinElmer)
Concentration / Polymorphism / Surface
Mapping
Raman Scattering (Scan Stage, Flexible
Probe)
RamanStation 400 (PerkinElmer)
Concentration / Reaction Kinetics
In-lineNear-IR Spectroscopy
(Diffuse Reflection)
SentroPAT FO (Sentronic), Probes: DR LS 300 (Dynisco)
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Overview Analytical Services VI
19.04.2023RCPE Overview Services
7
AttributeMeasurement
PrincipleMeasurement Device
ConcentrationSeperation via Ultra-High Pressure Liquid
Chromatography
Acquity UPLC + MS( Waters)
Concentration
Seperation via Liquid Chromatography / Photo Diode Array
Detector
Agilent 1260 HPLC + PDA(Agilent)
Identification of Substances
Triple- Quad Mass Spectroscopy
Alliance HPLC + MS(Waters)
ConcentrationSeperation via Gas Chromatography
Clarus500 (PerkinElmer)
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Overview Analytical Services VII
19.04.2023RCPE Overview Services
8
AttributeMeasurement
PrincipleMeasurement Device
Contact Angle / Surface Tension
Sessile Drop and Captive Bubble Method
(Static & Dynamic)
Easydrop (Krüss)
Contact Angle / Surface Tension
Washburn Method for Powders / Sessile Drop
and Captive Bubble
KT100 (Krüss)
Nanoparticle InclusionSpray Drying (Piezoelectric
Pulverizer)
Nano Spray Dryer B-90 (Büchi)
Residual Moisture Content
Karl Fischer TitrationTitroLine 7500 KF
(SI Analytics )
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Overview Analytical Services VIII
19.04.2023RCPE Overview Services
9
AttributeMeasurement
PrincipleMeasurement Device
Particle Shape / Imaging
MicroscopyDM4000 with
DFC290 Camera (Leica)
Weight (Precision 0.01 mg)
High Precision ScaleXP205DR /m
(Mettler Toledo)
Characterize Flow of Materials / Elasticity
EC Motor Drive with Normal Force and
Torque Sensor
Physica MCR 300
(Anton Paar)
Transformation Enthalpies / Specific Heat
Differential Scanning Calorimetry
DSC 204 F1 Phönix(Netzsch)
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Overview Analytical Services IX
19.04.2023RCPE Overview Services
10
AttributeMeasurement
PrincipleMeasurement Device
Particle Separation due to differences in their size,
shape, or density Sifting Segregation
Jenike & Johanson Segregation Tester SS1
Testing of inhaled products, measuring the
aerodynamic particle size distribution
Inertial ImpactionCopley Scientific Cascade Impactor
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Overview Process Services I
Attribute Process Principle Process Device
Hot Melt ExtrusionPlastification, mixing,
degassing, shaping by twin screw
Micro 27 Extrusion System(Leistritz)
Hot Melt Extrusion
Plastification, mixing, degassing, shaping by
twin screw
ZSK18 Extrusion System(Coperion)
Downstream extrusion Rotating knifeDie Face Pelletizer
Prototype(Automatik)
Downstream extrusion Rotating knifeStrand Granulator P60E
(Automatik)
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Overview Process Services II
Attribute Process Principle Process Device
Mixing 3D rotation Shake MixerTurbula T2F
(WAB)
GranulationGranulation by applying
high shear forcesHigh Shear Mixer P25
(Diosna)
MillingCooling with liquid
nitrogen and millingCryo Mill (Retsch)
Capsule fillingFilling of capsules with
nozzles
Laboratory Capsule FillerLabby(MG2)
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Overview Process Services III
Attribute Process Principle Process Device
Tablet pressing Rotary pressLaboratory Tablet Press 102i
(Fette Compacting)
Tablet pressingSimulation of rotary
presses
Compaction SimulatorSTYLCAM 200R(MedelPharm)
Coating, drying, encapsulation
Fluid bedBatch Fluid
Bed System Ventilus(Innojet)
Coating, drying, encapsulation Fluid bed
Batch Fluid Bed System GPC G1
(Glatt Process Technology)
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Overview Process Services IV
Attribute Process Principle Process Device
Dosing of liquidsMicro annular gear
pumpHNP mzr 7205 G
Dosing of powder Loss in weight feederK-Tron
K-CL-SFS-KT20
Dosing of powderLoss in weight feeder
small scale
BrabenderDDW-DDSR20 Hyg.
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