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Click-based synthesis and antitubercular evaluation of dibenzofuran tethered thiazolyl-1,2,3-triazolyl acetamides.

Goverdhan Surinenia, Perumal Yogeeswarib and Dharmarajan Sriramb, Srinivas Kantevaria,c

a Organic Chemistry Division-II (CPC Division), CSIR- Indian Institute of Chemical Technology, Hyderabad-500

007, Telangana, INDIA. bMedicinal Chemistry and Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology

& Science-Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad-500078, Telangana, INDIA.cAcademy of Scientific and innovative Research, CSIR- Indian Institute of Chemical Technology, Hyderabad-500

007, Telangana, INDIA.

Supporting Information

Table of Contents ---------------------------------------------------------------- Page

1. General Experimental procedures and spectral data: S2

2. 1H NMR, 13C NMR and HRMS spectra of 2, 3, 4 and 6a-p: S3-S59

Experimental Section:

Corresponding author. Tel.: +91-4027191437; fax: +91-4027198933; e-mail: kantevari@yahoo.com, kantevari@gmail.com.

1

All the reactions were monitored by TLC (Precoated silica plates and visualizing under UVlight).

Air-sensitive reagents were transferred by syringe or double-ended needle. Evaporation of

solvents was performed at reduced pressure on a Buchi rotary evaporator.1H and 13C NMR

spectra of samples in CDCl3 and DMSO-d6 were recorded on Bruker UXNMR FT-300MHz

(Avance) spectrometer and Varian FT-500MHz (Inova). Chemical shift reported are relative to

an internal standard TMS (δ=0.0). Mass spectra were recorded in ESI conditions at 70 eV on an

LC-MSD (Agilent technologies) spectrometers. All high-resolution spectra were recorded on

QSTAR XL hybrid MS/MS system (Applied Bio systems/ MDS sciex, foster city, USA),

equipped with an ESI source (IICT, Hyderabad). Column chromatography was performed on

silica gel (60-120 mesh) supplied by Acme Chemical Co., India. TLC was performed on Merck

60 F-254 silica gel plates. Commercially available anhydrous solvents CH2Cl2, DMF, MeOH,

Acetone, t-BuOH and EtOAc were used as such without further purification.

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