big data and the promise of personalized medicine

Big data and the promise of personalized medicine

Indrek VainuHelsinki Business Hub

indrek.vainu@helsinkibusinesshub.fiMobile: +358 44 746 3902

Hello!

What is Personalized Medicine?

Customization of healthcare – decisions, practices, products tailored to individual patients

A lot of data

• The source code of you => 3.2 billion base pairs• Sequenced => 700 MB of data

http://cdn.trendhunterstatic.com/thumbs/illumina-hiseq-2500.jpeg http://thewinnower.com/blog/rejected-pt-1/

Beating Moore’s law

http://www.genome.gov/images/content/cost_per_genome_apr.jpg

Biobanks + data centers

http://www.ebo-enterprises.com/sites/default/files/images/07-14datacenter_lg.jpg

Genomics ROI

“Every dollar we invested to map the human genome returned $140 to our economy.”

--President Barack Obama, 2013 State of the Union address, Feb. 12, 2013

http://web.ornl.gov/sci/techresources/Human_Genome/publicat/BattelleReport2011.pdf

In the news …

The promise?

http://www.condenaststore.com/-sp/Here-s-to-the-human-genome-and-its-potential-in-finding-at-long-last-a-Cartoon-Prints_i8643225_.htm

The basis for personalized medicine

Benefits

•Genetic testing to select drugs–Xalkori, non-small cell lung cancer drug–Treatment cost $10,000 / month–Works only for ALK-positive gene mutation

patients (3-5%)–Testing costs $400–24 out of 25 patients do not respond–BOTTOM LINE => testing all $10,000 vs $250,000/month

• Categorized treatment plans

• Identifying responding patients

http://abcnews.go.com/Health/CancerPreventionAndTreatment/lung-cancer-pill-crizotinib-highlights-improved-iding-treating/story?id=14414833

Finland well positioned

• Finland has:–several biobanks–unique genomic

composition–electronic medical

records–research infrastructure

• Recently:–Biobank Act to use

biobank data for research purposes

Thank you