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Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710 11.2017

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Biograph VisionSee a whole new world of precision

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

… we were inspired to makebreakthrough improvements thatwould revolutionize PET/CTby going beyond digitalto address our customers’ needs.

Although as a modality,PET/CT has vastlyimproved the practiceof healthcare...

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

100%SiPM

sensorcoverage1

84 cps/kBq1

effectivesensitivity

Biograph VisionGoing beyond digital with the Optiso UDR detector

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

3.2 mmLSO

crystals

249 ps1

time-of-flight

AccuracyPerformanceReproducibilityOptiso UDR

Beyond digital

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph VisionSee a whole new world of precision

Accuracyto reveal the bigger picture

Performanceto maximize efficiency

Reproducibilityto better understand disease progression

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Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

We want to help you address personalized medicine byfocusing on clinical insights while driving sustainable outcomes

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Data acquired under IRB-approved protocol. Data on file.Biograph Vision and its features and applications and are currently underdevelopment and are not for sale in the U.S. Their future availability cannotbe guaranteed. They do not yet fulfill all the essential requirementsaccording to the European Medical Device Directive (93/42/EEC) and itsnational implementations and are not yet commercially available in theEuropean Union.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Get the full potential out of your PET/CT with new options

OncoFreeze

CardioFreeze

FlowMotionMultiparametric

PET Suite

Static OncoFreeze

Dual gating CardioFreeze

Images virtuallyfree of motion

Additional parameters for more information relatedto therapy effectiveness ⇓ Absolute quantification

1

2

3Biograph Vision, OncoFreeze, CardioFreeze and FlowMotion Multiparametric PET Suite are currently under development and are not for salein the U.S. Their future availability cannot be guaranteed. They do not yet fulfill all the essential requirements according to the EuropeanMedical Device Directive (93/42/EEC) and its national implementations and are not yet commercially available in the European Union. 1Datacourtesy of University of Tennessee, Knoxville, USA,2Data courtesy of University of Michigan, Ann Arbor, USA, 3Data courtesy of University ofGeneva, Geneva, Switzerland. All images were acquired on a Biograph mCT system.

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Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Proprietary LSO crystals

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.. 1Compared to BGO scintillators.

Siemens is the only PET manufacturer thatowns the entire manufacturing process of thedetector.

• Grown, cut, and individually selected in-house

• Self-manufactured to enable precisespecifications and complete detectorredesign

LSO scintillator for fast time-of-flight andexcellent image quality1

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Reducing crystal size improves spatial resolution and contrastrecovery, thus improving detectability

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. Based on internal measurements available attime of publication. Data on file.

Biograph Vision™

High-resolution torso phantomSphere size (mm): 5.0, 7.9, 9.9, 12.4, 15.4, 19.86:1 contrast-to-background

5 mmsphere

5x5 crystalmini-block

3.2 mmLSO crystal

element

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

All planes of a modified Defrise phantom are clearlyvisible with Biograph Vision, even off-center

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Biograph Vision

3 mm

4 mm

5 mm

3 mm

4 mm

5 mm

Centralposition

20 cmoff center

Axial resolutionphantom

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Clear visualization of the 2.4 mm cylinders of theMini-Derenzo phantom with Biograph Vision

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Biograph VisionDiameter (mm)

1.21.6

2.4

3.24.0

4.8

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

249 pstiming

resolution1100%

coverage1

of the LSOarray

SiPMs cover 100% of the LSO array, maximizing the detectionof light from the scintillator

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

More coverage equals faster time-of-flight

Time-of-flight performance depends on collectinglight from all photons in the scintillation.

• SiPMs cover the entire LSO-array area,maximizing the detection of light from thescintillator

• 100% coverage, enabling fast temporalresolution1

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

249 pstiming

resolution1100%

coverage1

of the LSOarray

Stable time-of-flight performance over a large activity range

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

0

100

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0 5 10 15 20 25

Tim

ing

reso

lutio

n1(p

s)

Activity (mCi)

Timing resolution and activity

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

249 pstiming

resolution1100%

coverage1

of the LSOarray

Time-of-flight performance at 249 ps enables smallsegments of response

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

3.7cm

249 ps

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

3.2 mmLSO crystal

element

608electronicchannels

100%coverage1

of the LSOarray

5x5 crystalmini-block

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

A new approach to detector design with Biograph Vision

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Optimal performance in a wide range of count rates with thenew Optiso UDR detector

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Optiso Ultra Dynamic Range (UDR)

• Fast time of flight and high effectivesensitivity provide excellent performance inlow and medium activity ranges such as 90Y,18F and 68Ga applications.

• A small block detector with low deadtimemakes it suitable to operate in the high-activity concentrations found in studies withvery short-lived tracers, such as 82Rb and 15O.

18F: Data courtesy of Kantonsspital Baselland, Liestal, Switzerland11C: Data courtesy of Zentralklinik Bad Berka, Bad Berka, Germany82Rb: Data courtesy of Central Manchester University Hospitals, Manchester, UKImages for illustration purposes only. Data acquired on Biograph mCT system.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

A completely new high-performing detector with the visionof expanding clinical and research capabilities

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

A complete redesign of the PETdetector focusing on:

• Accuracy• Performance• Reproducibility The new

Optiso UDRdetector

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph Vision shares the solid foundationof Biograph mCT’s clinical workflow and software

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

• Large 78 cm bore

• FlowMotion continuous bed motion

• And new, unique features

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Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Large bore improves access and comfort

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

78 cm

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

1.97 mscan range1

227 kgmaximum

patientweight1

Designed to support a broad patient population

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

High spatial resolution throughout the field-of-view

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availability cannotbe guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC) and its nationalimplementations and are not yet commercially available in the European Union. Data courtesy of the Ohio State University, Columbus, Ohio, USA.Data acquired on a Biograph mCT system. 1Based on internal measurements available at time of publication. Data on file.

FBP FBP OSEM OSEMAxial Transverse Axial Transverse

1 cm 3,9 3,8 3,6 3,410 cm 4,8 4,6 4,0 3,920 cm 5,1 5,1 4,7 4,1

0,0

1,0

2,0

3,0

4,0

5,0

6,0

FWHM

(mm

)1

Biograph Vision

1 cm10 cm20 cm

1 cm

10 cm

20 cm

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph Vision’s high performance enables low injected doseand short scan time

Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union. 1Based on internal measurements available attime of publication. Data on file.

86 cps/kBqeffective

sensitivity1

• Low injected dose• Short scan time

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph VisionNeurology

Data acquired under IRB-approved protocol. Data on file.Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Sharply delineated cortical uptake, with high contrast betweenthe gray and white matter. There is impressive definition of thegyri, basal ganglia and cerebellum.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph VisionOncology

Data acquired under IRB-approved protocol. Data on file.Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Sharp delineation of the muscleand fat planes, vertebral marginsand end plates, biliary radicals,renal calyces, aortic wall andpapillary muscles of the heart.

Unrestricted © Siemens Healthcare GmbH, 2017 MI-3710

Biograph VisionCardiology

Data acquired under IRB-approved protocol. Data on file.Biograph Vision and its features and applications and are currently under development and are not for sale in the U.S. Their future availabilitycannot be guaranteed. They do not yet fulfill all the essential requirements according to the European Medical Device Directive (93/42/EEC)and its national implementations and are not yet commercially available in the European Union.

Visualization of the heart with impressive clarity, includingremarkable delineation of the left ventricular edge andpapillary muscles even without cardiac gating.