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BMedSc Bachelor of Medical Science Year 1 Modules: Cellular Biochemistry and Biology
Module Description
The aim of this module is to provide a basic understanding of protein biochemistry and build from this to provide an overview of the key processes in cell biology. Description of the fundamental elements of protein structure and function together with the relevant chemical principles will provide a context for understanding the basic quantitative elements of biochemistry and an appreciation of the applications for proteins in biomedicine. This will provide the student with sufficient background to understand the second phase of the module, where the fundamental elements of the cell will be discussed, including cell structure, motility, adhesion, signalling, proliferation, trafficking and regulation.
Module Content
Session Session Title
Lecture Introduction to the Module
Lecture Charge and shape in biological reactions
Lecture Protons and their Impact
Lecture Maintenance of pH
Self Directed Learning Solutions dilutions
Lecture The components of proteins
Small Group Teaching Ionisation and pH
Lecture Protein structure dictates function
Small Group Teaching SOD Session 1
Lecture Protein Partners
Lecture Protein Interactions
Small Group Teaching Protein Structure
Lecture Measuring protein activity
Small Group Teaching SOD Session 2
Lecture Fluorescence in biochemical analysis
Small Group Teaching Spectroscopy
Lecture Energetics of protein action
Lecture Dynamics of Protein Action
Self Directed Learning Cellular Reactions
Self Directed Learning Inhibitors
Lecture Controlling protein action
Lecture Extracting proteins from biological sources
Laboratory Practical Enzyme Review
Small Group Teaching Kinetics
Small Group Teaching SOD Session 3
Lecture Analysis of protein properties
Lecture Protein applications in biomedicine
Small Group Teaching Purification
Lecture How we study cells
Self Directed Learning SOD Session 4
Lecture Moving cargo in the cell
Lecture Keeping cells together
Self Directed Learning Motors
Lecture The scaffold of the cell
Self Directed Learning Adhesion
Lecture Cell structure - membrane compartments
Small Group Teaching Cell adhesion
Small Group Teaching SOD Session 5
Lecture Cell movement
Lecture The social life of cells
Small Group Teaching Motility
Lecture Communication between cells 1
Lecture Communication between cells 2
Small Group Teaching Signalling
Small Group Teaching SOD Session 6
Lecture Cell growth and proliferation
Lecture Regulating cell numbers
Small Group Teaching Cell Cycle
Lecture Moving into the nucleus
Small Group Teaching SOD Session 7
Self Directed Learning Adhesion
Lecture Getting to the cell surface
Lecture Controlling activity in the cell
Laboratory Practical Cell Cycle (Part 1)
Small Group Teaching Transport
Lecture Latency and activation
Laboratory Practical Cell Cycle (Part 2)
Lecture Review of the module
Small Group Teaching SOD Session 8
Small Group Teaching SOD Session 9/10
Learning Outcomes By the end of the module students should be able to:
1. Describe the principle of chemical ionisation and apply this knowledge quantitatively in the context of pH, buffers and protein action
2. Give an overview of protein structure, including its origin during biosynthesis, the forces responsible for its maintenance and its relevance to macromolecular assembly and protein substrate interaction, and to apply this in the context of structure/function relationships
3. Describe the basic aspects of enzyme kinetics and its analysis and apply this knowledge to interpret a simple experimental data set
4. Describe the basis of the key methodologies used to purify and analyse proteins and use this information to design a simple preparative or analytical process
5. Describe the underlying structure of the cell and the contributions of the cytoskeleton, cell adhesion and membrane compartments to cell function
6. Describe the basic strategies used by cells to communicate and how this influences cell proliferation and to apply this knowledge to design experimental outlines to investigate its consequences
7. Describe key intracellular trafficking events used to transport cargoes between compartments of the cell and the relationship of these processes to the activation and degradation of proteins
Assessment Module assessment will comprise a combination of a written unseen paper and in-course assessments: Examination (2 hours; 2 from 4 essays and 6 SAQs): 75% In course assessment 25%: Students will give individual 10 minute oral presentations, each covering a specified aspect of the module (12.5%) and a January MCQ (50 questions, 1 hour, 12.5%). Hours Academic staff to deliver 33 lecture sessions, 110 small group sessions (10 SGTs taught as 2 x 5 groups and 10 tutorials) and 18 (2 x 9) hours of practical work.
BMedSc Bachelor of Medical Science Year 1 Modules: Cardiovascular Science
Module Description
This module will provide students with a detailed understanding of the functioning and control of the heart and vasculature. The module will be delivered by scientific and clinical research experts within the College to ensure a broad perspective to the subject rooted in current state-of-the-art research knowledge. This module will provide a foundation from which the student will build their knowledge, skill and experience in this area should they choose to study the subject further in the third year or in postgraduate studies. The module is organised into a series of themes: the heart, the vascular system and control mechanisms. In each theme a combination of lectures, small group discussion, practical work and interactive sessions will be used to encourage the students to apply their knowledge about the system and develop generic skills that can be applied to other modules.
Module Content
Session Session Title
Lecture Coronary Circulation
Lecture Cardiac Function: EC Coupling
Lecture Cardiac Function: Failing Heart
Lecture Cardic arrhythmicity
Lecture Physical Characteristics of Blood
Small Group Teaching
Cardiac Function: Review of Material in Lectures L04-L06
Lecture Red and White Cell Circulation
Lecture Dysregulated Leukocyte Trafficking in Chronic Disease
Lecture CNS Control of Cardiovascular System
Lecture Disturbances of Blood Pressure and Volume
Small Group Teaching
Cardiovascular Pathology - Review of materials in lectures L10-L12
Lecture Review of the Respiratory System
Lecture Central(neural) Control of Respiration
Lecture Pheripheral (Chemical) Control of Respiration
Practical Exercise and Blood pressure reg
Lecture Pulmonary Function of Circulation
Lecture Normal and Abnormal Pulmonary Function
Lecture Respiratory Failure
Lecture Integration of Cardiovascular & Respiratory Function
Small Group Teaching Respiration: Review of materials in lectures L13-L17
Lecture Temperature Regulation
Lecture CVRS Integration: Exercise
Lecture Integration: Alerting response, Vasovagal syncope
Lecture CVRS integration: sleep
Lecture acclimatisation to high Altitude
Practical Pulmonary Function in Rest and Exercise
Small Group Teaching CVRS Integration
Small Group Teaching
Pulmonary function in rest and exercise - review of practical data
Seminar Interactive Demonstration
Lecture Introduction to the Cardiovascular and Respiratory System
Learning Outcomes By the end of the module students should be able to:
1. Describe the basic structure and function of cardiovascular system and how it enables oxygen and metabolic fuel to reach tissues, and carbon dioxide and waste products to be removed.
2. Evaluate the use of genetic, molecular, cell, tissue and whole organism (including man) approaches to the study of the cardiovascular system
3. Apply knowledge gained from reference to experimental research models about cardiac structure and function in normal circumstances and disease.
4. Apply knowledge gained from reference to experimental research models used for understanding vascular structure and function in normal circumstances and disease.
5. Describe the central mechanisms responsible for controlling the cardiovascular system using knowledge gained from an understanding of the research methods currently used in this area.
Assessment Module assessed by one piece of in course assessment and a written, unseen examination End of year 1 hr examination (75%) – 1 hr: a selection of 15 MCQs, 2 from 4 SAQs, 1 from 2 Essays
ICA (25%) – Data interpretation exercise Hours Total contact hours: 37: 15 hr Lectures; 12 hr Tutorials; 10 hr practical classes/workshops; 63 hrs guided independent study
BMedSc Bachelor of Medical Science Year 1 Modules: Drug Action
Module Description
The module aims to familiarise the students with the principles of pharmacology as a quantitative science. Coverage of the basic principles is supported by a systems based consideration of some of the potential mechanisms for the pharmacological manipulation of the peripheral and central nervous systems, the gastrointestinal tract, inflammatory processes, infection and cancer.
Module Content
Session Session Title
Lecture Principles of Drug Action
Lecture Introduction to Quantitive Pharmacology
Tutorial Tutorial 1
Lecture Pharm Methods and Meas
Lecture Drugs Affecting the Neuromuscular Junction
Lecture Absorption and Distribution of Drugs
Lecture Local Anaesthetics
Tutorial Tutorial 2
Lecture Drug Metabolism and Excretion
Lecture Introduction to Autonomic Pharmacology
Lecture Drugs Affecting the Parasympathetic Nervous System
Tutorial Tutorial 3
Lecture Adrenergic Pharmacology 1
SGT Autonomic Function and Dysfunction
Com Practical Cardiolab 1
Lecture Anti-Cholinesterases
Tutorial Tutorial 4
Lecture Histamine and Histamine Receptor Antagonists
Lecture Emetics and anti-drugs
Lecture Cardiolab assessment
Tutorial Tutorial 5
Lecture Pharmacokinetics 1
Lecture Pharmacokinetics 2
Student Presentation Presentations
Tutorial Tutorial 6
Lecture Opiate
Lecture Alcohol
Lecture Cytotoxic drugs
Tutorial Tutorial 7
Tutorial Tutorial 8
Lecture Adverse drug reactions
Lecture Principles in chemotherapy
Tutorial Tutorial 9
Lecture Anti-viral chemo
Lecture Anti-parasitic chemo
Practical Drugs Affecting the Isolated Ileum of the Guinea-Pig
Learning Outcomes By the end of the module students should be able to:
1. understand the concept of a drug receptor and appreciate the nature of these receptors 2. define the terms agonist, antagonist, partial agonist, affinity and efficacy, and
understand the importance of these parameters in determining the properties of drugs
3. realise the importance of pharmacokinetics in influencing the response to a drug 4. know the mechanisms of action and side effects of selected drugs affecting a)
the peripheral nerves, b) the central nervous system, c) the gastrointestinal tract, d) inflammatory processes and e) infectious organisms and cancer cells
5. appreciate the ways in which differences between individuals can influence the response to, and toxic effects of, drugs
6. present and interpret data from simple pharmacological experiments 7. work as a group to prepare and deliver an oral presentation
Assessment The module is assessed by a combination of a 1 hr written, unseen examination and in course assessment. Examination 75% (Semester 2) ICA 25% (Semester 2) The examination will comprise 25 MCQs and 4 SAQs from a choice of 6. The ICA component will comprise the following: Group seminar presentation
Hours Total contact hours: 100: 20 hr Lectures; 6 tutorials and a 2h seminar session for each of 10 groups (=80h).
BMedSc Bachelor of Medical Science Year 1 Modules: Digestion and Renal Sciences
Module Description
The module links the function of the main nutritive inputs (through Digestion) and their waste outputs (Renal Sciences). The processes of digestion, absorption and excretion in the gastro-intestinal tract and associated organs are introduced to provide a system-based appreciation of specific function/dysfunction. The Digestive science component covers the physiology of the gastrointestinal tract with a strong relevance to gastrointestinal disease. The Renal Science component covers the anatomy, physiology and toxicology of the kidney and urinary tract, and the role of the kidneys in homeostasis of osmolarity, volume and acid-base. Most pertinently both aspects of the module align with research performed within the college of MDS and thus provides students with the opportunity to experience cutting edge research within the college of MDS.
Module Content
Session Session Title
Lecture Introduction and Overview of the Digestive System
Lecture Functions of the mouth/oesophagus and associated diseases
Lecture Gross Anatomy of the Digestive System
Lecture Secretion in the Stomach and its control
AnatPrac Histology of the Gut Wall and Glands
Lecture Secretion in the pancreas and intestines
Lecture Control of Smooth Muscle in GI Tract
Lecture Motility in the GI Tract
Lecture Function of the Liver and Hepatobiliary System
Lecture Jaundice
Lecture Absorption Ions and Water
SGT Digestion 1 – GORD
Lecture Control and Absorption of Iron
Lecture Digestion and Absorption of Carbohydrate and Protein
SGT Digestions 2 – Jaundice
Lecture Digestion and Absorption of Fat
Lecture Fed/fasted states and Metabolic Disorders
Exam Essay under examination
SGT Digestion 3 – Pancreatitis
Lecture Glycogen synthesis and breakdown
Lecture Nutrition 1 – Normal Physiology
SGT Digestion 4 – Iron Deficiency
Lecture Nutrition 2 – Starvation/Obesity
Lecture Acute and Chronic Inflammation of the GIT
Lecture Cancers of the GIT
Exam Turning Point Formative MCQ
Exam Assessment Session / MCQ
Learning Outcomes By the end of the module students should be able to:
1. Understand the gross anatomy of the organs of the digestive, renal and urinary systems (including their relations to other organs in the abdomen and pelvis), and demonstrate an understanding of their functions and processes.
2. Appreciate the mechanisms of digestion, motility, absorption and elimination as applied to the major organs and classes of food.
3. Understand the special features of the renal blood supply which adapt the organ for filtration and reabsorption, and how blood flow and GFR can be measured
4. Describe the transport properties of the nephron and how these relate to excretory function of the kidneys
5. Understand the role of the kidneys in regulating body fluid osmolarity, volume and acid-base balance; and the methods of investigation used to obtain this knowledge.
6. Understand the cause and types of the major diseases of the gastrointestinal tract and how this impacts on its function
7. Understand the role of food in society, of nutrition and disordered nutrition and metabolic disturbance in diabetes.
8. Understand the role of the kidneys in regulating body fluid osmolarity, volume and acid-base balance; and the methods of investigation used to obtain this knowledge.
9. Understand how drugs, including anti-ulcer treatments and diuretics, can modify digestive and renal function.
10. Use independent thought processes to discuss and evaluate scientific material.
Assessment The module is assessed by a combination of written examination (2 hours, consisting of 20MCQs, 4 from 6 SAQs and 2 from 4 essays) and course work.
Examination 75% (Semester 2) Course work 25% (Semester 2) The course work component will consist of an essay (2000 words excluding references). Hours Total contact hours: 57: 36 hr Lectures; 13 tutorials 2hr demonstration; 6 practical classes/workshops
BMedSc Bachelor of Medical Science Year 1 component: Employability Skills passport (Level C) non credit-bearing
Component Description The purpose of this component is to encourage students to develop a number of skills which are critical for their on-going development on the course but also for their future employability prospects. To achieve this goal, the component will focus on the non-module specific skills acquired during the year. This will not require any additional assessment but emphasises and rewards engagement of students with these elements. Furthermore, it ensures that students are not progressing with deficiencies in their skills which could put them at a significant disadvantage in subsequent years.
Students shall normally be required to:
1. Attend, engage with and contribute to all identified compulsory teaching sessions, including anatomy, laboratory and computer practicals, small group teaching sessions, tutorials and progress tutorials.
2. Engage with their Personal Tutor during Progress Tutorials and reflect on the subject and transferable/employability skills that they are developing with the aid of feedback that they have received.
Component Outcomes By the end of the component students should be able to:
1. Demonstrate a basic level of ability to contribute to communicate orally and in writing scientific concepts and/or data
2. Undertake laboratory work safely and competently, to the level taught at level C 3. Demonstrate a willingness to work effectively in groups and contribute to the
achievement of common goals 4. Demonstrate a willingness to engage in reflective practice relating to their
learning experiences
BMedSc Bachelor of Medical Science Year 1 Modules: Fundamentals of life science
Module Description
The module introduces basic concepts in biomedical sciences and provides a sound knowledge base for subsequent cellular and systems-based modules. It comprises a series of lectures, small group sessions and laboratory-based practical sessions that will lead to an in-depth understanding of some fundamental principles of human biology. The structure and function of DNA, RNA, proteins and lipids are introduced at the beginning of the module. Later, the physiology of fluid compartments and the biochemistry of energy generation are considered. The fundamental principles of human embryological development, and the anatomy of some of the major structures of the body are presented. The biology of bacteria, including their structure and genetics, antibiotics and antibiotic resistance are introduced. The biology of viruses, viral infection and virus-receptor interactions are considered, and an introduction to immunology, including innate and adaptive immunity is presented. A number of experimental technologies, including DNA cloning and sequencing, polymerase chain reaction and the use of antibodies as experimental tools are discussed.
Module Content
Session Session Title
Lecture Introduction to the module
Lecture Structure and properties of RNA
Lecture Amino acids and proteins
Small Group Teaching Breaking the Code
Tutorial Assessment tutorials : essay setting and feedback
Laboratory Practical Core Labskills 1
Lecture Translation
Lecture Enzymes
Anatomy Practical Introduction to histology and classification of tissues
Laboratory Practical Core Labskills 2
Anatomy Practical Preparation and visualisation of histological specimens
Laboratory Practical Core Labskills 3
Anatomy Practical Epithelial tissue
Small Group Teaching Metabolism II
Anatomy Practical Epithelial tissue
Anatomy Practical Topography and histology of the skin
Lecture Early embryonic development
Lecture Gastrulation and the formation of the body plan
Small Group Teaching Hold - Spare Slot (as per Wendy/Lisa)
Lecture Development of the organ systems – ectoderm and nervous system
Lecture Development of the organ systems – mesoderm
Anatomy Practical Histology and histopathology of connective tissue
Lecture Development of the body systems – body folding and endoderm
Lecture Recombinant DNA and cloning
Small Group Teaching Embryology I
Lecture Introduction to infection and immunity
Small Group Teaching Embryology II
Lecture Structure of bacterial cells
Laboratory Practical Gram Stain 1
Anatomy Practical Histology of cartilage and bone
Laboratory Practical Gram Stain 2
Small Group Teaching Experimental Procedures
Lecture Genetics of bacteria
Lecture Virology: Your cells under new management
Anatomy Practical Muscle anatomy
Lecture Antibiotics
Lecture The ‘lock and key’ model of virus-receptor interaction
Small Group Teaching Bacteriology
Tutorial assessment tutorials : essay setting and feedback
Small Group Teaching Bacteriology
Lecture DNA viruses, clinical features and replication
Lecture Innate immunity
Small Group Teaching Virology
Lecture Adaptive immunity
Small Group Teaching Immunology
Lecture Introduction to immunology
Learning Outcomes By the end of the module students should be able to:
1. demonstrate a basic knowledge and understanding of the structure of DNA, RNA, proteins and lipids, and the fundamental principles of replication, transcription and translation.
2. demonstrate a basic knowledge and understanding of the fundamental principles of physiology including the role of cell membranes, fluid compartments and the principles by which cell volume and composition is maintained.
3. demonstrate a basic knowledge and understanding of the fundamental principles of biochemistry including an appreciation of metabolic pathways such as glycolysis and gluconeogenesis, and the mechanisms by which energy is generated in the cell.
4. demonstrate a basic knowledge and understanding of the fundamental principles of human embryological development including fertilisation and organ development, and including an appreciation of how developmental defects can arise.
5. demonstrate a basic knowledge and understanding of the fundamental principles of human anatomy including an appreciation of the structure and function of epithelial tissues, connective tissues, muscle and the skin.
6. demonstrate a basic knowledge and understanding of the fundamental principles of bacteriology, including the structure of bacterial cells, the genetics of bacteria, antibiotics and antibiotic resistance.
7. demonstrate a basic knowledge and understanding of the fundamental principles of virology including viral infection and virus-receptor interactions.
8. demonstrate a basic knowledge and understanding of the fundamental principles of immunology including innate and adaptive immunity.
9. demonstrate a basic knowledge and understanding of the fundamental principles of DNA cloning and sequencing, polymerase chain reaction, the use of antibodies as experimental tools and other experimental techniques that are routinely used in modern research laboratories.
Assessment The module is assessed by a combination of written (2 hours comprising 6/8 SAQ and 2/4 essays) and course work. Written examination 75% Course work 25% The course work component will comprise of: Essay (1500 word) 12.5% January MCQ exam (50 questions) 12.5% Hours Total contact hours: 200: 34 hr Lectures; 20 tutorials; 11 practical classes/workshops
BMedSc Bachelor of Medical Science Year 1 Modules: Foundations of Neuroscience
Module Description
This is the first of a series of systems and/or subject based course elements in Years 1 and 2. It considers the structure and function of the nervous system and synaptic communication in general and then goes on to cover in greater detail the structure and function of the sensory, autonomic and enteric nervous systems. It is linked to the following modules: Cardiovascular Science, Digestive & Renal Systems and Drug Action. These links reflect a) the integration between the physiological control of the cardiovascular and digestive system with the nervous system and b) the importance of synapses in the peripheral and central nervous systems and as drug targets.
Module Content
Session Session Title
Lecture Introduction to the Module
Lecture Membranes and Cell Excitation
Lecture The Basis of Excitability
Lecture Neurones, Synapses, Role of Transmitters
Lecture Synaptic signalling
Computer Practical Sensory Receptors PBL A
Computer Practical Introduction to Neurones in Action (session 1)
Small Group Teaching Action Potentials
Lecture Glia - form and function
Computer Practical Introduction to Neurones in Action (session 2)
Computer Practical Sensory Receptors PBL B
Computer Practical Neurones in Action: The Na+ Action Potential (session 1)
Computer Practical Neurones in Action: The Na+ Action Potential (session 2)
Lecture The Neuromuscular Junction
Small Group Teaching Neuronal Circuits
Anatomy Practical Histol and Histopath of Nervous System 1 and 2
Lecture Somatic Nervous System: an Overview
Lecture Nerve and Muscle: Degeneration and Re-innervation
Small Group Teaching Nerve Function and Dysfunction A
Practical Nerve Action Potentials
Anatomy Practical Topography of Brain, Spinal Cord and Cranial Nerves
Lecture Chemical Senses
Computer Practical Neuroscience Assessment 1
Anatomy Practical Topography of the Sensory Systems
Lecture Sensory System: Vision
Lecture Sensory System: Somatosensory
Small Group Teaching Nerve Function and Dystfunction B
Lecture Sensory System: Audition
Lecture Simple Reflexes
Small Group Teaching Sensory Systems
Lecture Anatomy of the Autonomic Nervous System: an Overview
Lecture Functioning of the Autonomic Nervous System: an Overview
Lecture The Enteric Nervous System
Anatomy Practical Anatomy of the Autonomic Nervous System: an Overview
Lecture Concepts of Brain Function
Computer Practical Neuroscience Assessment 2
Learning Outcomes By the end of the module students should be able to:
1. Appreciate the topographical organisation of the nervous system; in particular, the sensory division of the somatic, the enteric and autonomic nervous systems. Also, be familiar with the distribution and function of the cranial nerves
2. Understand the principles by which neurons are able to: receive and recognise information from the internal and external environments; to generate electrical signals; to communicate with other cells via synapses (including the multisynaptic pathways of simple reflexes)
3. Demonstrate an awareness of the structure and function of the organs involved in the special senses of sight and hearing and chemical senses
4. Demonstrate knowledge of the different glial cell types in the nervous system and their function and roles.
5. Be able to present and interpret data generated by a quantitative experiment.
Assessment The module is assessed by a combination of written examination and course work. Written examination 75% (semester 2) Course work 25% (semester 1 and 2) The examination is composed of the following sections:
A: 4 short notes, at least one of which must be on an anatomy topic (out of 6 questions in total; 4 on general module content, 2 on anatomy teaching) B: 1 essay question (out of 2). Examination sections will be weighted equally. The course work component will include the following: Practical write up with questions 12.5% MCQ test 12.5% (taken in January) Hours Total contact hours: 38.5: 18 hr Lectures; 9 tutorials; 11.5 practical classes/workshops
BMedSc Bachelor of Medical Science Year 1 Modules: Introduction to Molecular and Experimental Genetics Module Description
The aim of the module is to provide a basic understanding of the causes and consequences of human genetic variation. A description of the molecular methods for investigating pathological genetic variations in man will provide the student with sufficient background to be able to understand the approaches used to investigate the molecular pathology of human disorders.
Module Content
Session Session Title
Lecture Recombinant DNA & Cloning
Lecture Experimental Technology 1: DNA and RNA
Lecture Experimental Technology 2: RNA
Lecture Experimental Technology 3; Antibodies as experimental tools
Tutorial Assessment Tutorial
SGT Problem Based Session
Lab Practical Molecular Biology Techniques
Lecture Origin of genetic variation – meiosis
Lecture Origin of genetic variation – mutation
Lecture Mutation; origin, pattern and implications
Lecture Molecular pathology – (I) The consequences of gene mutation
SGT Karyotype Analysis
Lecture Molecular pathology – Functional essays
Lecture The future: mammalian cloning and uses of stem cells
Lecture Problem based learning. Genes in pedigrees
SGT Pedigree Analysis
Learning Outcomes By the end of the module students should be able to:
1. Describe the basis of germline genetic variation in man. Also understand the importance and origin of the germline mutation rate in the male and female.
2. Understand at a basic level the role of mutation in evolution. 3. Describe the patterns of Mendelian inheritance in man as well as how
mitochondrial inheritance is different from this. 4. Describe the range of human chromosome disorders particularly those arising
from chromosomal non- disjunction and their consequences for the individual. 5. Describe the methods, at a basic level, that are used to investigate gene
mutation and chromosome abnormalities in man as utilised in an NHS genetics laboratory.
6. Explain the consequences of gene mutation in terms of its effect on protein function and how this effect can be measured in the laboratory.
Assessment Module assessment will consist of a combination of a written unseen paper and a single in course assessment. Written examination 75% Consisting of a 1 hour written examination (15 MCQ, 2 short answer questions and 1 essay question). Course work 25% Practical class write-up Hours Total contact hours: 30: 18 hr Lectures; 8 tutorials; 4 practical classes/workshops (the shorter version of the practical class had been scheduled for 4h) This practical would run twice (each with half the class)
BMedSc Bachelor of Medical Science Year 1 Modules: Introduction to Research and Experimental Skills
Module Description
Research and experimental design are key concepts for someone working within a scientific discipline to understand. This module will teach these key skills, whilst giving the students exposure to the best biomedical research within the College. It will seek to inspire and motivate them, whilst teaching core academic skills such as literature searching and evaluation. It will look at the full life cycle of research, from project design, via practical issues of setting up a piece of research, to effectively communicating its outcomes via academic writing and presentation. We will introduce the consideration of bioethics and current experimental approaches and their use in modern biology. The module will provide training in the application of statistical methods to experimental design and data analysis.
Module Content
Session Session Title
Lecture Introduction to BMedSc Year 1
Lecture Intro to module- life cycle of research
Practical Library Skills and using the library
Practical Literatures Searches and the Internet
Lecture HoS Research strengths
Practical Cluster session. (word, excel, powerpoint skills
Small Group Teaching Assessing the quality of sources
Practical Cluster session. (word, excel, powerpoint skills
Small Group Teaching Head of Student Support
Small Group Teaching Myth busters-research design
Lecture Health & Safety
Practical Research taster 1- lab tour
Practical Research taster 1
Small Group Teaching What is an abstract?
Small Group Teaching Mythbusters - Experimental Design
Lecture The scientific process. Experimental design (controls, outliers, repetition)
Lecture Stats I Intro to Stats
Lecture Stats II Vetting variability and pursuing population parameters
Small Group Teaching Debates Part 1
Lecture Stats III Do Smarties make you smarter?
Small Group Teaching Data handling (basic numeracy, buffers, unit conversion)
Lecture The effect of the change in the HE tuition fee structure on subject choice
Small Group Teaching Data interpretation worksheet (e.g. Statistics)/ Focus on statistical analysis (basic)
Lecture Experimental techniques to solve a research problem (1)/ Gene expression. Westerns, PCR & Q-RT PCR
Practical Research Taster Slot
Lecture The Stroop test
Practical Research taster 2 - Ppt discussions (formative assessment)
Lecture The effect of voter turnout on general election results
Learning Outcomes By the end of the module students should be able to:
1. Demonstrate an understanding of how to communicate scientific concepts (e.g. written report and poster session)
2. Perform a literature search to identify material appropriate to a given topic (poster session and written report)
3. Demonstrate an awareness of how to design an experiment and be able to propose suitable methods to address a basic research question (poster session and written report).
4. Demonstrate knowledge of the different glial cell types in the nervous system and their function and roles.
5. Understand, be able to apply and interpret appropriate statistical methods to simple unseen experimental data (MCQ).
Assessment The module will be assessed by two components: 1) A Group work poster presentation on their final Research taster visit, (including literature background, future experimental design, methods and outcomes) : 20% Associated individual written report (1500 words): 30% 2) A Statistics MCQ exam (30, 1 from 5 MCQs in 1 h): 50% Students MUST pass both components- i.e. both are required components to pass the module. Students, who miss their final Researcher taster day due to a justifiable reason, will be given a handout so they are still able to complete the Poster activity and written report. Hours Total contact hours: 64: 20 hr Lectures; 32 tutorials; 4 hr IT cluster sessions; 8 hr supervised time in studio/workshop/lab
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