boswellia serrata akba-may09
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Boswellia Serrata AKBA
Nutra Specialities India
March 2009
Rejuvenates Joint Cartilage
by inhibiting the
5-lipoxygenase activity
Boswellia Serrata AKBA
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What is Boswellia Serrata
Boswellia has long been an Ayurvedic medicine.
Boswellia Serrata contains boswellic acids
which plays as a vital role for treatment of
various anti-inflammatory conditions.
Boswellia shows good improvements in
curing Inflammation, Colitis, Cancer,
Osteoarthritis, Bronchial Asthma, etc.
Boswellia extract is considered as analternative to NSAID due to less side
effects.
Historical Boswellia
Boswellic acids are natural extracts of the plant Boswellia
serrata which are biologically active pentacyclic triterpenes of
Frankincense derived from the gum resin of the tree of the
family Burseraceae.
Frankincense is being used extensively all over the world in
various clinical conditions, specifically employed to alleviate
the signs and symptoms in chronic arthritis conditions.
Frankincense that had been a compound in the European
pharmacopeia till 1900, went into oblivion since then.
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Boswellia Composition
Boswellia consists of 6 Major acids
1. - Boswellic Acid
2. - Boswellic Acid
3. 3 Acetyl - - Boswellic Acid
4. 3 Acetyl - - Boswellic Acid
5. 11-keto - - Boswellic Acid
6. 3 Acetyl -11- keto Boswellic Acid - AKBA
Research data suggests that of the various boswellic acids, 3 Acetyl -
11 keto Boswellic Acid or AKBA, is considered the most active and
powerful acid. AKBA helps preserve the structural integrity of joint
cartilage, promotes gastrointestinal health and maintains a healthy
immune mediator cascade at the cellular level.
The Frankincense extract contains beta-boswellic acids
(BA) 10 to 21%, 3-O-acetyle--boswellic acids (ABA) 0.05
to 6%, 11-oxo-b-boswellic acids (KBA) 2.5 to 7.5% and 3-O-
acetyle-11-oxo-b-boswellic acids (AKBA) 0.1 to 3%.
In conventional Boswellia of these major 6 Boswellic acids
AKBA is present in the range of 0.1 to 3% only.
Nutra Specialities India introduces AKMAX standardized
to contain minimum 35% of AKBA.
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Highest Quality Standards
Specifications
AKMAX Nutra
Specialities India
Conventional Boswellia
Serrata Extract
Color and Appearance
Off White to pale Yellow
free flowing powder with a
characteristic resinous
taste.
Off White to pale Yellow
free flowing powder with a
characteristic resinous
taste.
Organic Acid
(Titration Method) >90% >70%
AKBA
(HPLC Method) >30% 2-3%
Recommended Dosage 50-150 mg/day 500-1500 mg/day
We also follow Pharmaceutical Standards in Consistent Quality Management.
o Water by KF
o Loss on Drying
o Heavy Metal
o Microbial Analysis
Biological Actions Joint Support: Boswellia AKBA helps preserve the structural integrity of joint cartilage,
promotes gastrointestinal health and maintains a healthy immune mediator cascade at the
cellular level. Boswellia maintain healthy 5lipoxygenase (5LO) activity, moderating
leukotriene biosynthesis and AKBA inhibit the leukotriene biosynthesis by a non-redox,
noncompetitive inhibition of 5-LO.
Immune Support: In addition to maintaining healthy 5LO activity, exciting new research has
revealed that 5LO may influence healthy gene expression of immune compounds. In studies,
5LO has demonstrated the potential to support joint motility and comfort, in part by
promoting a healthy immune response. It may also play a role in maintaining healthy matrix
metalloproteinase (MMP) activity, supporting connective tissue structural composition.
Gastrointestinal Support: A randomized double blind study revealed that AKBA supports
gastrointestinal health. AKBA has also maintained healthy immune activity in the endothelial
lining of the digestive tract. AKBA supports healthy cell signaling and cell cycle function for
high capacity cellular support.
A series of chronic inflammatory diseases are thought to be perpetuated by leukotrienes.
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AKBA Inhibits 5-Lipoxygenase and stops biosynthesis of Leukotrienes.
Name : 3 Acetyl -11- keto Boswellic Acid Chemical Formula : C32H48O5 Molecular Weight : 512.73 Melting Point : 271 C CAS Number : 67416-61-9
Pathway of Boswellia AKBA
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Properties
The new improved AKMAX from Nutra extracts is potent in anti-inflammatory action for enhanced results.
This unique extract shall be employed in; the treatment of chronicinflammatory conditions such as Rheumatoid Arthritis, Chronic Bronchitis,Asthma, Chronic inflammatory bowel diseases (Ulcerative Colitis, CrohnsDisease) as well as Chronic inflammatory skin diseases (Atopic Dermatitisand Psoriasis).
In addition to maintaining healthy 5-LO activity, exciting new research hasrevealed that AKBA may influence healthy gene expression of immunecompounds.
In OA patients, AKBA controls and inhibits degeneration of cartilage tissuecaused by the MMPs such as MMP-3 which are over-expressed andabundant in fluids of the synovial cavity.
The 5-LOX Paradox
The key enzyme in the conversion of Arachidonic Acid into
LTB5 is 5-Lipoxygenase (5-LOX).
Inhibition of 5-LOX thus assumes special significance when it
comes to the management of chronic inflammatory disorders.
Boswellic acids also act as efficient inhibitors of MAP Kinases
& Topoisomerises.
New studies show conclusively that 5-LOX products directly
stimulate prostate cancer cell proliferation via several well-
defined mechanisms.
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Saturated and Omega-6 fats convert to Arachidonic acid in the body. One way that thebody rids itself of excess arachidonic acid is provoking a dangerous metabolizing pathway
through 5-lipoxygenase (5-LOX).
Arachidonic acid is metabolized by 5-LOX to 5-hydroxyeicosatetraeonic acid (5-HETE), a
potent survival factor that prostate cancer cells use to escape destruction.
In addition to 5-HETE, 5-LOX also metabolizes arachidonic acid to leukotriene B4, a potent
proinflammatory agent that causes destructive reactions throughout the body and inflicts
severe damage to the arterial wall.
In response to arachidonic acid overload, the body increases its production of enzymes
like 5-LOX to degrade arachidonic acid. Not only do 5-LOX products directly stimulate
cancer cell propagation, but the breakdown products that 5-LOX produces from
arachidonic acid (such as leukotriene B4, 5-HETE, and hydroxylated fatty acids) causetissue destruction, chronic inflammation, and increased resistance of tumor cells to
apoptosis (programmed cell destruction).
How 5-LOX Paradox - Works
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Other Benefits
Arthritis
Respiratory System Disorders
Gastro-Intestinal Tract
Anti-Cancer
-- Its actions are very targeted-- It promotes Bone and Joint health
Arthritis In Indian Ayurvedic medicine Boswellia serrata has been used for
hundreds of years for treating Arthritis.
Osteoarthritis (OA) affects nearly 21 million people in the USA, accountingfor 25% of visits to primary care physicians.
Extracts ofBoswellia serrata have been clinically studied for Osteoarthritis(OA) and joint function, particularly for osteoarthritis of the knee
As an anti-arthritic, AKMAX with AKBA reduces the chipping off oflycosaminoglycans, the base substance for cartilage repair unlike the
commonly used NSAIDs and COX-2 inhibitors.
AKMAX helps to shrink inflamed tissues by improving the blood supply tothe affected area and enhances the repair of damaged blood vessels.
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Arthritis
A human study on patients with osteoarthritis of the knee showed that
boswellia decreased pain, increasing physical functioning significantly in
range of motion and endurance.
Patients receiving AKBA treatment reported
decrease in knee pain, increased knee flexion and
increased walking distance. The frequency of
swelling in the knee joint was decreased.
An inflamed knee joint that occurs in osteoarthritis.
Respiratory System Disorders
AKMAX inhibits Human Leukocyte
Elastase (HLE) that causes Emphysema
and stimulates mucus secretion leading
to Cystic Fibrosis, Chronic Bronchitis,
Bronchial Asthma etc.
Bronchial Asthma is a disease of the lungs
in which an obstructive ventilation
disturbance of the respiratory passages
evokes a feeling of shortness of breath.
Bosellia serrata extract induces the activation of calpain
in HeLa human cervical carcinoma cells.
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Inflammatory Bowel Diseases
Group of conditions which are inflammatory, affectingthe tissue that lines the gastrointestinal system (the largeand small intestine) is classed as an inflammatory boweldisease (IBD).
Animal studies shows significantly reduced macroscopicand microscopic inflammation.
Gastro-Intestinal Tract AKMAX due to their inhibitory effects on 5-LOX exerts an anti-
inflammatory activity and is found to be useful in the treatment of
Ulcerative Colitis and Crohns disease.
Boswellia extracts cause immuno modulation by simultaneously inhibiting
TH1 and promoting TH2 cytokine production. They regulate vascular
responses to inflammation and stabilize mast cells.
In cases of intestinal inflammation, boswellic acids may modulate the
adhesive interactions between leukocytes and endothelial cells, bycountering the activation of leukocytes and/or down-regulating the
expression of endothelial cell adhesion molecules.
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Chronic Colitis
Colitis is a chronic digestive disease characterized by inflammation of thecolon.
The inflammatory process in colitis is associated with increased formationof leukotrienes.
General signs and symptoms of colitis
- Pain, depression,
- Aches and pains within the joints, changes in bowel habits
- Fever; swelling of the colon tissue, ulcers on the colon,
- Diarrhea.
Anti-Cancer All Boswellic acids have been shown to inhibit the growth of leukaemia
cells in human leukaemia HL-60 in culture, in a dose dependent manner.
Boswellic acids induce antiproliferation, differentiation and apoptosis inleukemia cell lines. They exert cytotoxic effects on established humanglioblastoma and leukemia cell lines, as well as on primary humanmeningioma cells.
Boswellic acids may help reduce cerebral edema in patients with braintumors, helping reduce the need for steroids and their significant adverseside effects.
Research show AKBA inhibited cellular growth in colon cancer cells.
AKBA has also been found to inhibit tumor cell growth and induceApoptosis.
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Human Studies - Arthritis
Kimmatkar N, Thawani V, Hingorani L, Khiyani R.MS Orthopedics, IndiraGandhi Medical College, Nagpur, India. Efficacy and tolerability of Boswelliaserrata extract in treatment of osteoarthritis of knee--a randomized doubleblind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7
Trial: To assess the efficacy, safety and tolerability of BoswelliaSerrattaExtract
Subject: 30 Patients
Treatments: 250mg of Boswellia
Outcome: - decrease in knee pain,
- increased knee flexion and
- increased walking distance.
- the frequency of swelling in the knee joint was decreased
Human Studies - ArthritisSengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D,Raychaudhuri SP., India., A double blind, randomized, placebo controlledstudy of the efficacy and safety of 30% AKBA for treatment of osteoarthritis ofthe knee. Arthritis Res Ther. 2008;10(4):R85. Epub 2008 Jul 30
Trial: To evaluate the efficacy and safety of 30% AKBA in thetreatment of osteoarthritis (OA) of the knee
Subject: 75 Patients; 90 Day double-blind, randomized, placebo-controlled
Treatments: 100mg of Boswellia AKBA
Outcome: Significant improvements in pain score and functionalability in the AKBA admitted patients
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Animal Studies - Inflammatory
Krieglstein CF, Anthoni C, Rijcken EJ, Lauktter M, Spiegel HU, Boden SE,etal.Department of General Surgery, Westfalian Wilhelm's University,Waldeyerstrasse 1, 48149 Mnster, Germany. Acetyl-11-keto-beta-boswellic acid, aconstituent of a herbal medicine from Boswellia serrata resin, attenuatesexperimental ileitis. Int J Colorectal Dis. 2001 Apr;16(2):88-95
Trial: Leukocyte-endothelial cell interactions in inflammatorybowel disease on rats
Subject: To determine the efficacy of Boswellia extract andAKBA
Treatments: Boswellia AKBA
Outcome: Both Boswellia extract and AKBA decreased rolling (up to90%) and adherent leukocytes (up to 98%), attenuated tissueinjury scores, and significantly reduced macroscopic andmicroscopic inflammation of the gut mucosa.
Human Studies - InflammatoryGupta I, Parihar A, Malhotra P, Gupta S, Ldtke R, Safayhi H, AmmonHP.Department of Medicine, Medical College Jammu, J&K, India.Effects of gum resin of Boswellia serrata in patients with chronic colitis.Planta Med. 2001 Jul;67(5):391-5
Trial: The gum resin of Boswellia serrata and control for
the treatment of chronic colitis disease.
Subject: 20 for BSE and 10 for Control; 3 *300mg 6 weeks
Treatments: 900mg of Boswellia/daily
Outcome: 14 of 20 from BSE and 4 of 10 from control shownimprovement in colitis
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Human Studies - Inflammatory
Gupta I, Gupta V, Parihar A, Gupta S, Ldtke R, Safayhi H, AmmonHP.Pharmakologie fr Naturwissenschaftler, Pharmazeutisches Institutder Universitt Tbingen, Auf der Morgenstelle 8, D-72076 Tbingen,Germany. Effects of Boswellia serrata gum resin in patients withbronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res. 1998 Nov 17;3(11):511-4
Trial: To treat Bronchial Asthma disease
Subject: 40 for BSE 18-75 years; 3 *300mg 6 weeks and40 for Control 14-58 years; 3 *300mg 6 weeks
Treatments: 900mg of Boswellia/daily; Double Blinded
Outcome: In BSE group shows 70% improvement in Asthmaconditions and in control group only 27% showedimprovements
Human Studies Anti-CancerLu M, Xia L, Hua H, Jing Y. Division of Hematology/Oncology, Department ofMedicine, Mount Sinai School of Medicine, New York, New York 10029-6547,USA. Acetyl-keto-beta-boswellic acid induces apoptosis through a deathreceptor 5-mediated pathway in prostate cancer cells. Cancer Res. 2008 Feb15;68(4):1180-6
Trial: The apoptotic effects and the mechanisms of action ofAKBA to Induce Apoptosis in human prostate cancercells.
Subject: Human Prostate Cancer Cells
Treatments: Boswellia AKBA/twice daily
Outcome: AKBA induces apoptosis in prostate cancer cellsthrough a DR5-mediated pathway. AKBA resulted as anovel inhibitor in treatment of cancer cells.
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Corporate Office:Nutra Specialities IndiaNo: 5, Vivekananda Street, Spurtank Road,
Chetpet, Chennai 600 031,Tamil Nadu, India.
Phone: +91 44 4284 9552 / 9553Fax: +91 44 4284 9856Email: marketing@nutraforlife.com
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5100 Highlands Parkway, SE
Smyrna, GA 30082
Dir: 1-770-373-5333
Phone: 1-770.916.1722 ext. 101
www.nutraforlife.com
Boswellia Serrata AKBA
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