calcium signalling. why calcium? [ca 2+ ] i maintained very low – prevents precipitation of...
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- Slide 1
- Calcium Signalling
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- Why Calcium? [Ca 2+ ] i maintained very low Prevents precipitation of organic anions
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- Why Calcium? Divalency - stronger protein binding than monovalent ions. Large [Ca 2+ ] gradient [10 -7 vs. 10 -3 M]
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- PM Ca 2+ -ATPase ER Ca 2+ -ATPase Calsequestrin Mitochondrial high capacity (low affinity) pump
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- Target TissueSignaling MoleculeMajor Responses LiverVasopressinGlycogen breakdown PancreasAChAmylase secretion Smooth muscleAChContraction Mast cellsAntigenHistamine secretion Blood plateletsThrombinaggregation
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- Turn the Pathway Off Voltage-gated Ca 2+ channels inactivate IP 3 rapidly dephosphorylated Ca 2+ rapidly pumped out Phosphatases are activated (CaMKII)
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- Ca 2+ as a 2 nd Messenger (contd) Ryanodine Receptors (RyR) Important for skeletal muscle Caffeine is an example of a reversible activator of RyRs IP3 receptors Inositol-1,4,5-P3
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- Gq Signalling - Calcium Signalling Tyrosine kinase Signalling Calcium Signalling
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- Paari Dominic Swaminathan et al. Circulation Research. 2012;110:1661-1677 Copyright American Heart Association, Inc. All rights reserved.
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- The domain structure of a calmodulin-dependent protein kinase II (CaMKII) monomer. Paari Dominic Swaminathan et al. Circulation Research. 2012;110:1661-1677 Copyright American Heart Association, Inc. All rights reserved.
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- Ca-Responsive Transcriptional Activation cAMP-response element (CRE) CaM KII and Ras-ERK1/2 signaling pathways NFAT
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