cancer drugs approved quickly but not to patient's benefit, researcher says

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Science News from research organizations

Cancer drugs approved quickly but not topatient's benefit, researcher says

May 7, 2015

York University

Highly priced cancer drugs get rushed approvals despitepoor trial methodology and little effect on the longevity ofpatients, cautions one expert, who adds that drug reviewersdon't look at the long term survival of patients who takethem.

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Highly priced cancer drugs get rushed approvalsdespite poor trial methodology and little effect onthe longevity of patients, cautions York UniversityProfessor Dr. Joel Lexchin in the School of HealthPolicy and Management.

"Patients and their doctors should demand that regulators require pharmacompanies to provide clear evidence of clinical effectiveness of the drugs,resulting from rigorous methodology," suggests Lexchin. "Drug agencieslike the Food and Drug Administration (FDA) and the European MedicineAgency (EMA) don't actually look at whether people live longer."

In an article in the British Medical Journal, titled "Why do cancer drugs getsuch an easy ride?," Lexchiin and co-author Donald Light, a professor inthe School of Osteopathic Medicine, Rowan University in New Jersey, notethat accelerated approval and shortened review times also make it asmooth sail for cancer drugs.

Lexchin cites earlier research reviewing solid cancer drugs within 10 yearsof EMA approval to point out that these drugs improved survival by justover a month.

"Similarly 71 drugs approved by the FDA from 2002 to 2014 for solid

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Cite This Page :

York University. "Cancer drugs approved quickly but not to patient'sbenefit, researcher says." ScienceDaily. ScienceDaily, 7 May 2015..

tumours have resulted in median gains in progression-free and overallsurvival of only 2.5 and 2.1 months, respectively," he says adding, "Also,only 42 per cent met the American Society of Clinical Oncology CancerResearch Committee's criteria for meaningful results for patients."

Story Source:

The above story is based on materials provided by York University. Note:Materials may be edited for content and length.

Journal Reference :

1. D. W. Light, J. Lexchin. Why do cancer drugs get such an easyride? BMJ, 2015; 350 (apr23 1): h2068 DOI: 10.1136/bmj.h2068

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