carol friedman, d.o. associate director for adult immunization immunization services division

Carol Friedman, D.O.

Associate Director for Adult Immunization

Immunization Services Division

National Center for Immunization and Respiratory Diseases

Centers for Disease Control and Prevention

Seasonal Flu Vaccine Update2009-2010

Seasonal Flu Vaccine Supply

• June 2009 vaccine manufacturers state 118 million doses of seasonal flu vaccine will be produced

• August 2009 numbers revised to 114 million doses produced

• Represents ~3% reduction from original projection

• Amount of vaccine distributed similar to 2008-2009 flu season

U.S. Seasonal Influenza Vaccine: Production and Use

Doses Produced (millions)

Doses Distributed (millions)

2006 120.9 102.5

2007 140.6 112.8

2008 135.9 113

2009 114 (est) 112.7*

*Amount reported by manufacturers to CDC which is being validated.

Vaccine Supply Challenges

• Vaccine available much earlier

• Increased demand

• Facilities switched to production of H1N1 vaccine production

• Delay in availability of vaccine

• Pre-booked orders canceled or reduced

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7-Aug 21-Aug 4-Sep 18-Sep 2-Oct 16-Oct 30-Oct 13-Nov 27-Nov 11-Dec 25-Dec 8-Jan

Mill

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Week of Incidence

2004 2005 2006

2007 2008 2009

# o

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Weekly Flu Vaccinations in Medicare Population in 2009 Compared to 2004-2008Measurement Criteria: Procedure on Any Claim Processed as of Week 2 in Jan10

Long-Term Care Facilities (LTCF) Affected

• Reports of vaccine shortages among LTCFs– Orders canceled or reduced

• Additional 500,000 doses made available for LTCF in December

• Pharmacies, supermarkets, community vaccinators provided vaccine

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7-Aug 21-Aug 4-Sep 18-Sep 2-Oct 16-Oct 30-Oct 13-Nov 27-Nov 11-Dec 25-Dec 8-Jan

Week of Incidence

2006 2007 2008 2009

Rate

of V

accin

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ns (p

er

1,0

00)

Weekly Flu Vaccination Rate in 2009 Compared to 2006-2008Measurement Criteria: Procedure on Any Claim Processed as of Week 2 in Jan10

Population: Part D Medicare Institutionalized

Demand Remains High

• Cumulative seasonal influenza vaccination coverage since August was 42% by Jan 2

• Demand for seasonal vaccine remains higher than supply (139-173 million vs. 114 available)– Majority of people report they have gotten, will

definitely get, or will probably get seasonal flu vaccine (58%)

Outlook for Next Season

• ACIP Influenza Work Group considering universal flu recommendation

– Begin 2010-2011

– Two stage

• Encourage for 2010-2011

• Full implementation 2011-2012

• Fluzone High Dose Vaccine

– High-dose seasonal flu vaccine for persons ≥65 years

– Contains 4 x amount of antigen

– FDA licensed December

Outlook for Next Season (2)

• Preliminary reports indicate manufacturers plan to make at least as much vaccine as this year

– Will this be enough?

• Vaccine composition

– Strains will be identified at VRBPAC* meeting in February

– Likely include 2009 H1N1 strain

*Vaccines and Related Biological Products Advisory Committee

Thank You!!

Questions??