correlation between retinopathy of prematurity and levels of
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Correlation between Retinopathy of Prematurity and Levels of
Proinflammatory Cytokines
Presented in Trisakti University July 2012I Gusti Agung Ayu Widyarini
030.09.113
Retinopathy of Prematurity in The World
WHO: First cause of blindness in infants in
developed and developing countries
Indonesia: First cause of blindness in preterm
infants
Retinopathy of Prematurity
Vascular disorder of infants with gestational age less than 28 weeks and is accompanied by low birth
weight
1. Shastry BS. Genetic susceptibility to advanced retinopathy of prematurity (ROP). J Biomed Sci 2010; 17:69.
Pathogenesis of ROP
1. Sapieha P, Joyal JS, Rivera JC, Duchemin EK, Sennlaub F, Hardy P, et al. Retinopathy of prematurity: understanding ischemical retinal vasculopathies at an extreme of life. JCI 2010; 120(9): 3022-30.
Fails to limit retinal oxygenation
The regrowth becomes overstated, deregulated, and
misguide
Arrest in vascular development
Stages of ROP
1. Piscitelli. Different stages of retinopathy of prematurity. Accessed in June, 28th 2012. Available at: URL: http://ropmalpractice.com/?page_id=19
Cytokine: The Amazing Protein
1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6 th ed. Philadelphia: Elsevier Saunders; 2007. p. 267-70.
Cytokines are proteins secreted by the cells of innate and adaptive immunity that
mediate many of the functions of these cells,
include hematopoietic cells
Proinflammatory Cytokines in Plasma
1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6 th ed. Philadelphia: Elsevier Saunders; 2007. p. 267-70.
Correlation between ROP and Levels of Proinflammatory Cytokines
1. Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Seminars in Fetal and Neonatal Medicine 2012: 26-9.
BDNF
IL-1β
TNF-α
IL-8
IL-6
NT-4
IGF-I
Proinflammatory cytokines
VEGF
Studies
Study Year Subjects Duration of Intervention Result
Sood et al 2009
877 preterm neonates with
birth weight 401-1000 gr
21 days
↑ IL-6↑ CRP
↓ TGF-β, BDNF, NT-4
Silveira et al2005
-2007
74 very low birth weight infants 27 months
↑ IL-6↑ IL-8
↑ TNF-α
1. Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, et al. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatric Research 2010; 67(4): 394-400.
2. Silveira RC, Filho JBF, Procianoy RS. Assessment of the contribution of cytokine plasma levels to detect retinopathy of prematurity in very low birth weight infants. IOVS 2011; 52(3): 1297-300.
Conclusion
Retinopathy of prematurity is a vascular disorder that attacks the blood vessels of the retina in infants with
premature birth and low birth weight
There are significant association between retinopathy of prematurity in the inflammatory process that triggers
the secretion of proinflammatory cytokines
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