ctsi annual retreat 2011: a tale of summer

Clinical and TranslationalScience Institute / CTSIat the University of California, San Francisco

CTSI Annual Retreat 2011A Tale of Summer

S. Claiborne Johnston, MD, PhD

Associate Vice Chancellor of Research & CTSI Director

“Daddy, why does the train stop

here?”

- Teo Johnston, Age 8

Evolution of an Industry

• Start-up/building phase

– Hire

– Build basic structures

– Start slow but accelerate

1857

Investors

• European investment groups.

1850 1860 1870 1880 1890

New England 2,507 3,660 4,494 5,982 6,831

Middle States 3,202 6,705 10,964 15,872 21,536

Southern

States2,036 8,838 11,192 14,778 29,209

Western

States and

Territories

1,276 11,400 24,587 52,589 62,394

Pacific States

and

Territories

23 1,677 4,080 9,804

Totals 9,021 30,626 52,914 93,301 129,774

US Regional Miles of Railroad

Railroads in 1918

1918

Number of industry-sponsored clinical

trials

0

20

40

60

80

100

120

140

160

180

200

new amendment No cost extensions

2009

2010

# c

on

tra

cts

n = 374

n = 423

Median Cycle Time for Industry Contractsfrom internal documents complete to final award – industry clinical trials

Ca

len

da

r d

ays

0

10

20

30

40

50

60

70

80

New Amendments no cost extensions

2008

2009

2010

IRB Approval Times

2009 139 days

2010 71 days

“Daddy, why does the train stop

here?”

- Teo Johnston, Age 8

Railroads in 1918

1918

2006

Evolution of an Industry

• Start-up/building phase

– Hire

– Build basic structures

– Start slow but accelerate

• Sustainability phase

– Prepare for change; keep eyes on future

– Consider more flexible approaches

– Continue to innovate

CTSI Retreat 2011

12:45-3:00 “CTSI Idol”

3:00-3:20 Break

3:20-4:00 Defining Success

4:00-4:20 Early Stage Translation

4:20-4:40 Improving the Health of SF

4:40-5:00 Closing Discussion

5:00-6:00 Reception