environmental signal integration by a modular and gate
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Environmental signal integration by a modular AND gate
J Christopher Anderson, Christopher A Voigt and Adam P Arkin
Molecular Systems Biology (2007) 3:133
AND gate
INPUT OUTPUT
A B A AND B
0 0 0
0 1 0
1 0 0
1 1 1
Amber stop codon
Nonsense mutation = point mutation in DNA sequence resulting in premature stop codon or nonsense codon in transcribed mRNA -> truncated/non-functional protein product.
Supressor = tRNA that can “read” nonsense codon and cause appropriate amino acid to be incorporated into peptide sequence.
Functionality
Mathematical model
Modularity
Concluding remarks
Independent promoters detecting different aspects of the environment (O2, pH, cell density, lactate, glucose) could be integrated to sense a specific environment.
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