food and drug interactions khalid a. al-madani, mph, dsc consultant in clinical nutrition & vice...

Food and Drug Food and Drug InteractionsInteractions

Khalid A. Al-Madani, MPH, DScConsultant In Clinical Nutrition & Vice Present

of Saudi Society for Food and Nutrition

Medications and Food Intake

Drug Complications That Alter Food Intake

Medications and Food Intake

(Conti.)

Medication That Alter Appetite

Diet-Drug Interactions and Absorption

Medication Effectson Nutrient Absorption

Drug-nutrient binding

Diet-Drug Interactions and Absorption (Conti.)

Diet-Drug Interactions and Absorption (Conti.)

Altered acidity in thestomach

Stomach Emptying Rate

Diet-Drug Interactions and Absorption (Conti.)

Diet-Drug Interactionsand Metabolism

An An increaseincrease leads to a leads to a decreasedecrease

in enzyme activityin enzyme activity in drug concentration in drug concentration

and effect and effect

ANDAND

A A decreasedecrease leads to an leads to an increaseincrease

in enzyme activityin enzyme activity in drug concentration in drug concentration

and effect and effect

Diet-Drug Interactionsand Metabolism ( Conti.)

Diet-Drug Interactionsand Metabolism ( Conti.)

A New Concern - A New Concern - GrapefruitGrapefruit

Can cause more Can cause more of a drug to be of a drug to be absorbed from absorbed from intestine – even intestine – even toxic levelstoxic levels

May cause a May cause a drug not to drug not to workwork

Diet-Drug Interactionsand Metabolism ( Conti.)

Diet-Drug Interactionsand Metabolism ( Conti.)Vitamin K and WarfarinVitamin K and Warfarin

Keep intake of foods containing Keep intake of foods containing Vitamin K constantVitamin K constant

Vitamin K is high in spinach, kale, Vitamin K is high in spinach, kale, cauliflower, broccoli and other cauliflower, broccoli and other leafy greensleafy greens

Also don’t take Vitamin K Also don’t take Vitamin K

supplementsupplement

Diet-Drug Interactionsand Excretion

Medication Effects onNutrient Excretion

Diet-Drug Interactionsand Excretion ( Conti.)

Dietary Effects onMedication Excretion

Diet-Drug Interactionsand Toxicity

Diet-Drug Interactionsand Toxicity ( Conti.)

MOA Inhibitors MOA Inhibitors No beer, red wine No beer, red wine No cheddar, brie, No cheddar, brie,

mozzarella cheesemozzarella cheese No beef or chicken liver, No beef or chicken liver,

cured meats, caviar or dried cured meats, caviar or dried fishfish

Diet-Drug Interactionsand Toxicity ( Conti.)

Conclusion

Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.

THANK YOUTHANK YOU

FORFOR

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