genetics 210: personalized medicine and genomics

Genetics 210: Personalized Medicine and Genomics

FOR: MDS, PHDS AND CURIOUS STUDENTS

SPRING TERM. TUE 2:15 – 4:05 THUR. 2:15-4:05GENOTYPING : $15 COPAYGENE210 .STANFORD.EDU: INFO AND FAQS

Today

Course overview (~30’)Informed consent (~30’)How to get genotyped (~10’)Questions (~15’)

Course Staff

Course Organizers: Stuart Kim (Dev. Bio., Genetics) Aaron Gitler (Genetics) Rosalind Chuang (Neurology)

TAs: Andrew Roos (Epidemiology) Thomas Roos (Epidemiology)

Published Genome-Wide Associations

Genetics 210: Personalized Medicine and Genomics

DiabetesHeart DiseaseCancer Alzheimer’s, Parkinson’s/Huntington’s

Human Ancestry

Height prediction

How much Neanderthal are you?

Neanderthal George Church, Harvard Geneticist

Stuart

All time record

Joint Genotyping Task Force2008-2010

Charles Prober Dean Hank Greely Law SchoolRuss Altman Genetics C. Braddock Med SchoolPat Brown Biochem. Gil Chu BiochemMike Grecius Neur.Sean David Med. SchoolCarlos Bustamente Gen. Harry Greenberg DeanRalph Horwitz Psych Louanne Hudgins EpiAnne James Legal Counsel Jesse Karmazin Med. SchoolStuart Kim Dev. Bio. Mark Krasnow BiochemPhil Lavori HRP David Magnus Cen. BMEKelly Ormond Genetics Alan Schatzberg Psych.Mike Snyder Genetics Atul Butte BMIKeyan Salari Med. School Mildred Cho Pediatrics

Personal Genotyping

Voluntary. You can use a public genome file instead of your own.

Confidential – instructors will not know who opted to be genotyped.

Private – Your own DNA information will not be revealed.

Counseling - genetic counseling via 23andMe and medical/psychological counseling via Dr. Alan Schatzberg (Psychology, Stanford).

Introductory Projects

Report on specific genetic locus. Published on SNPedia.com

Class room debate on FDA legislationUnanticipated opportunities that arise as you

explore your genome

Advanced Projects = (project + final)

Annotate whole-genome for Stuart Kim or Aaron Gitler (adopted)

Write a grant for Kaiser-Permanente GWAS (n=110,000)

Analyze exome sequence data from ALS patients

Write an algorithm for choosing minimal n number of people to sequence to get all sequence data in a population

Gene210

Three ManuscriptsTextbookPatentGrantiPhone App

in the news Chicago Medicine Magazine (story on page 18) Salon Web Magazine (9/2013) Stanford Medicine - DNA testing improves learning (8/13) San Jose Mercury News (5/2013) Time (2/2013) Nature USA Today San Francisco Chronicle Recap San Francisco Chronicle Genome Technology Stanford Press Release Nature Blogs LA Times Blog Genome Web Center for Genetics and Society Scientific American

Exploring Personal GenomicsAvailable at Amazon.com

How to get genotyping kits1. ATTEND THIS INFORMATION SESSION.2. MAKE CHECK $15 TO STANFORD.3. BRING CHECK TO KATHY FISHER IN

BECKMAN B300 .4. FILL OUT INFORMED CONSENT FORM5. BRING SAMPLES BACK TO KATHY B3006. WE WILL SHIP THE GROUP OF

SAMPLES BACK TO COMPANY TUESDAY 4PM FEB. 4

7. RESULTS IN 6-8 WEEKS.8. CLASS STARTS TUESDAY APRIL 1 ,

2012 .

https://www.23andme.com/user/claim/