g*)hi)ij 2#&$/3#45.67.%881&5)3599./%' /.%&.5#9 ......tnbc (n=74) inferred activity...

TNBC (n=74)HR+ (n=205)

Infer

red a

ctivit

ySi

gnific

ance

[-log 1

0(p)]

p=0.05

Infer

red a

ctivit

y G1-2 (n=117)G3 (n=162)

Sign

ifican

ce[-lo

g 10(p

)]Si

gnific

ance

!"#$%

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p=0.05

(%

p=0.05

Corre

lation

[Spe

arma

n Rho

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Infer

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Model Endpoint odd ratio/hazard ratio(95 CI) p-value

Cox OS 0.55 (0.39-0.77) 0.0005Cox DFS 0.62 (0.47-0.81) 0.0004

Logistic regression pCR 1.63 (1.12-2.36) 0.0107

M ?

ImmunityBio

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Coho

rtpr

opor

tion (

%)

High activity Normal activity Low activity

279 Geparsepto HER2-negative samples

1467

clini

cal c

ases

1467 reference clinical cases

>1200 example later-stage test cases

[Breast n=213]

Other

Breast

oo o ooo ooo oo

Mean

gene

set

expr

essio

nInf

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d ac

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scor

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Positive correlationNegative correlation

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