glomerular filtration rate

Glomerular Filtration Rate

(GFR) Done By

Budour Alzahrani - Reem Alattas

Under supervise

Amal AlQahtani - Amer Amro

Case Study

Outlines

Nuclear

Medicine

Procedures

Imaging

Procedures

Non-Imaging

Procedures

Imaging procedures

Myocardial perfusion imaging

Thyroid scan

Renogram

Bone scan

Non-Imaging procedures

GFR (in-vitro)

RBC’s (Red Cell Mass)

Schilling Test

Most Common…

Glomerular Filtration

Glomerular filtration rate (GFR) is a commonly accepted

standard measure of renal function.

GFR is calculated from the area under the plasma clearance

curve, which required multiple blood samples to be taken

over a period of several hours.

Glomerular Filtration Rate

Indications Calculation of dose in chemotherapy

Detection of renal failure

Assessment of donors for

transplantation

evaluation of single kidney function

Contraindication

Patients with ascites.

Edema or other expanded body space.

Patient’s Preparation • Excessive intake of drinks containing caffeine including tea, coffee

and Coke should be avoided after 10 pm the night before the

test because of their diuretic effect

• recommended to avoid high protein meals before the study

• Some drugs can reduce renal function, should be stopped e.g.

diuretics.

• Note patient’s height and weight

Radiopharmaceuticals • Cr-51 EDTA

Half Life : 27.7 days

Dose : 2.0 MBq I.V

• Tc-99m DTPA is also used.

Procedure Explain the procedure .

Inject the Cr-51 EDTA .

Ask the patient to come back after 2,3 and 4

hours from the injection time for blood sample .

01

02

03

Procedure 04

05

06

Centrifuge the blood samples.

Dispense 2 ml of plasma.

Count sample tube on Gamma counter.

Case study Case 1

Case 2 Age: 66y.

Gender: female.

Clinical history: Brest cancer.

Reason of study: assess kidney function before chemotherapy.

Age: 65y.

Gender: male.

Clinical history: DM , HTN .

Reason of study: diabetic nephropathy.

Normal Case Result Abnormal Case Result Case 1 Case 2

This sheet is used for calculation of Adult GFR

Conclusion • GFR is the best test to measure kidney function , and to determine

the kidneys filtration rate.

• GFR used to detect renal failure and to assess donors for kidney

transplantation, also help to assess patient kidney function before

chemotherapy.

References • PSMMC Protocol.

• (2016). Bnms.org.uk. Retrieved 11 May 2016, from

http://www.bnms.org.uk/~bnms/images/stories/downloads/documents/gfrguidelin

esv5.2.pdf

• http://www.nuclearmedicine.org.uk/gfr/GFR_autumn2003_web.pdf

Thank You