group 3: m. yusron hasani(105090100111037) a. muammar kadafi (115090101111012) nira meirita w....
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ANTIBODY AND ANTIGEN
Group 3:M. Yusron Hasani (105090100111037)A. Muammar Kadafi (115090101111012)Nira Meirita W. (115090100111017)Putri Indisari (115090107111021)
JURUSAN BIOLOGIFAKULTAS MATEMATIKA DAN ILMU
PENGETAHUAN ALAMUNIVERSITAS BRAWIJAYA
MALANG2013
ANTIGENSubstance that stimulates the production of
antibodies and can be recognised by a B cell receptor or antibody, or a T cell receptor.
Protein, polisakarida or other molecule Part of the antigen which comes into contact
with the antigen receptor is called the epitope or antigenic determinant
Epitope, or antigenic determinant, is a small, specific portion of an antigen recognized by the immune system such as antibodies. A single antigen usually has several different epitopes. The region on an antibody which recognizes the epitope is called a paratope. Antibodies fit precisely and bind to specific epitopes.
ANTIGEN STRUCTURE
linear or sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure
Conformational epitope that has a specific three-dimensional shape and its protein structure. In contrast, most antibodies recognize this epitope
Types of epitopes
The binding between antibodies and antigens has high specificity and affinity resulting from various structural and energetic aspects.
Is a non covalent bond ( similar mechanism as lock and key on enzyme and a substrate )
Happens because the molecular structure of an antibody typical
Antigen-Antibody Binding
Pre-natal used IgG as antibody
Post-natal used IgA from colostrum as antibody
Immune system on pre-post natal
Response to the first exposure to antigen called primary immune response, mediated by lympocytes, called naïve lympocytes
Subsequent encounters with the same antigen lead to responses, called secondary imune response
First exposure to antigen stimulate primary imun responses signalling by IgM few days after exposing.
Time between exposure and appearance of IgM antigen called the lag phase
In serum, IgG start to be detected 6-7 days after exposure
When second exposure to antigen occurs, secondary immune response in which IgM and IgG levels increased rapidly with a short lag phase
IgM levels did not exceed the peak levels of the primary response, but IgG levels rise much higher and lasts longer
Much better response faster on secondary immune response
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