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Health Sciences and Well-being Research Beacon
NEWSLETTER Autumn / Winter 2013
Faculty of Applied Sciences
Health Sciences and Well-being Research Beacon:
High quality research into contemporary health issues
From the lab through to clinical practice
Multi-disciplinary research teams that span fundamental and applied sciences
2
Foreword from the HSWB Beacon team
The HSWB Research Beacon is located in the Sciences Complex, City Campus, University of Sunderland
Contacts
Health Improvement and Well-being
Dr Lyn Brierley-Jones, Beacon Research Fellow
T: 0191 515 3492
E: lyn.brierley-jones@sunderland.ac.uk
Drug Discovery and Application
Dr Peter Dawson, Beacon Research Fellow
Tel: 0191 515 2572, E: peter.dawson@sunderland.ac.uk
General enquiries
Ms Glenda Young, Faculty Admin Assistant
(Research Beacons), T: 0191 515 2527
E: glenda.young@sunderland.ac.uk
Website
http://www.sunderland.ac.uk/research/areasofresearch/
healthsciencesandwell-beingbeacon
Welcome to the Health Sciences and Well-being
Research Beacon newsletter, Autumn / Winter 2013.
HSWB Beacon research is focused around two key themes:
Pharmaceutical and biological sciences
Mental health, healthcare and health behaviours
Within these, research groups are looking at:
Common mental health problems: from prevention to novel therapeutic interventions
Infection and immunology: from pathogenesis to treatment
Pharmaceutical sciences: from disease to medicines use
Understanding health behaviours: the impact of the individual and society on health
Cross cutting all research, a further research group looks at Knowledge translation and exchange
3
Middle-class alcohol time bomb
RESEARCH NEWS from the Health Sciences and Well-being Research Beacon
Middle-class profession-
als are risking serious
health problems by using
alcohol as a means of
stress relief, reward for
looking after a family and
working full-time, new
research has revealed.
Despite the common
perception that young people are the section of society most
affected by alcohol, new research shows it’s actually white
collar workers who are most guilty of alcohol abuse.
The research concludes that a complete overhaul of public
health messages is needed to give a more realistic picture of
those affected by alcohol. The research analysed the drinking
habits and the reasons for drinking among five different
groups of workers in the public and private sectors, aged
between 21 and 55.
The groups discussed their drinking patterns, their perceived
norms and how much alcohol they consumed on a personal
level as well as professional situations, such as entertaining
clients.
They found that those middle-class workers who drank at
home viewed alcohol as a reward for everyday chores after
work hours, such as looking after their children and cooking
dinner for the family. Alcohol was also used to alleviate
stress and as a way of telling the individual that they had
fulfilled their commitments. One respondent said drinking
alcohol after the children had gone to bed “makes me feel
like an adult again”.
In light of the new evidence researchers feel public health
warnings are failing to resonate with white collar workers
and have instead “actively reinforced their view that their
own alcohol use was problem-free”.
Instead, the report says that in future public health messages
should focus on a typical person and the damages that can
happen to their long-term health, and not solely the crime or
disorder that alcohol abuse can result amongst younger
members of society.
Dr Jonathan Ling, Senior
Lecturer in Public Health said:
“One of the issues that people
tend to focus on in relation to
alcohol use is ‘problem drink-
ing’. Problem drinking is usually
thought of in terms of young
people binge drinking in city
centres, or people with alcohol
dependency. However, what is
starting to be recognised is that
regularly consuming alcohol at
lower levels than would cause intoxication is likely to be
harmful to health, and that the people that drink most regu-
larly aren’t young people, but those who live in households
where someone has a managerial or professional job.”
Dr Lyn Brierley-Jones, HSWB
Beacon Research Fellow,
added: “Our research showed a
common perception among
some middle-class groups that
regularly drinking at home,
particularly drinking wine, is
safe and sensible, even though
such drinking often takes them
over the recommended daily
guidelines. These home drink-
ers don’t see their drinking
pattern as problematic, but evidence suggests that such
drinking will lead to significant health problems later in life,
and a major health burden for the NHS.”
Ling J, Smith K, Crosland A, Kaner E F S, Haighton C A, Brierley-Jones L and Wilson G (2012) The 'other' in patterns of
drinking: A qualitative study of attitudes towards alcohol use among professional, managerial and clerical workers.
BMC Public Health, 12 (892).
Dr Lyn Brierley-Jones
Dept of Pharmacy, Health
and Well-being
Dr Jonathan Ling
Dept of Pharmacy, Health
and Well-being
4
In profile: New Beacon members
Dr Graeme O’Boyle, Senior Lecturer in Immunology,
Dept of Pharmacy, Health and Well-being
Chemokines are a family of proteins that
control the directional movement of cells
throughout the body.
They have a key role in the functioning of
the immune system where they direct
white blood cells to migrate from the
blood stream into inflamed tissues.
Chemokines are also involved in the
metastatic spread of cancers from their
initial site to other organs.
My work has focused on endogenous
mechanisms that regulate chemokine
biology with a view to understanding
how they might be targeted for thera-
peutic intervention.
My work has been translated to a num-
ber of inflammatory diseases such as
rheumatoid arthritis, transplant rejection
(both bone marrow and solid organ), and
inflammatory bowel disease.
I also work on the pathological migration
of breast and skin cancers to the lung and
liver. graeme.o’boyle@sunderland.ac.uk
My PhD, awarded from Teesside University in 2008, involved
the study of femoral neck fracture fixation techniques using
cannulated screws.
Through a combination of finite element computer
simulation and mechanical testing, optimal screw placement
and tension was identified to improve the stability at the
fracture site to improve bone healing.
Having a sport science background, my current research
focusses on strategies to reduce injuries in sport.
This includes examining the mechanics of contact situations
in rugby union, such as the scrum and tackles, and the
analysis of player posture.
This research involves community rugby clubs as it is
important that player welfare is considered at all levels,
especially those where the availability of medical care is
limited and the risk increased.
I am also interested in the level of physical activity in non-
standard situations.
This has involved using GPS and activity monitors to
measure the level and intensity of movement at outdoor
festivals, as this is an untapped market for health
promotion.
eddie.bradley@sunderland.ac.uk
Dr Eddie Bradley, Senior Lecturer in Biomechanics
Dept of Sport and Exercise Sciences
5
In profile: New Beacon members
Dr Stephany Veuger, Senior Lecturer in Clinical Biochemistry
Dept of Pharmacy, Health and Well-being
A major focus of my research has been to evaluate DNA
repair inhibitors as potential drugs to be used in
combination with current therapies or as stand-alone
therapies in cancer treatment. I have supported anti-cancer
drug discovery projects by evaluating drugs to exploit
underlying molecular defects in a range of human cancers;
investigating interactive effects of proteins involved in the
sensing and responding to DNA damage; developing and
validating pharmacodynamic biomarkers for agents pro-
gressing to clinical trials.
My current research is focussed on the mechanisms of DNA
repair following ionising radiation/chemotherapeutic drugs
and the role of NFkappa B in mediating resistance. This is
important as by defining resistance mechanisms to ionising
radiation and clinically important DNA damaging agents, it
has important implications for the way in which cancer ther-
apies are used and how future regimens may be developed.
I have an
interest in both solid
tumours and
haematological
malignancies (AML,
CLL).
I am a Fellow of the
HEA. Previously, I
have held posts as an
associate lecturer at
Northumbria Universi-
ty teaching on the biomedical sciences programme and the
Open University where I continue to tutor the MSc in medic-
inal chemistry. I am a visiting practitioner on the global
scholars programme, St Georges University Grenada, and
was e-learning developer at Newcastle University.
stephany.veuger@sunderland.ac.uk
I am a pharmacist working with a
community pharmacy for about six years
now. I have always wanted to develop my
pharmaceutical career. I am really
interested in the formulation of drugs,
especially hydrophobic drugs, as more than
40% of the drugs used are poorly water sol-
uble.
So, during my PhD study I will be working on
the best techniques for the formulation of
oral lipophilic drugs. I think it is really
interesting how lipophilic drugs are
formulated in a way to be absorbed in the
aqueous environment of the
gastrointestinal system, because they are
easily excreted from GIT before they are
fully dissolved and absorbed into the
systemic circulation.
Hence in my PhD studies I am exploring the
techniques that enhance the drug
dissolution to get optimal absorption and
bioavailability of lipophilic drugs, using solid
dispersion, lyophilisation technique, and
combination with cyclodextrines.
Ashraf Saleh, PhD student under the supervision of Dr Amal Ali Elkordy, Dr Ken
McGarry and Dr Cheng Shu Chaw, Dept of Pharmacy, Health and Well-being
Ashraf Saleh
Pharmaceutics researcher
Spotlight on Beacon PhD researchers
6
How wearing red helps you win
RESEARCH NEWS from the Health Sciences and Well-being Research Beacon
MANCHESTER United, Ferrari’s
Formula 1 team and the Spanish
football team all have one thing in
common which may explain their
success.
New research has found evidence to
show that putting on a red shirt can
give individuals and teams a physical
and psychological advantage.
Previous research has shown that wear-
ing red can be an advantage in compe-
tition, either by inhibiting opponents or
by giving the wearers of red a form of
mental advantage.
Now research from the University of
Sunderland has shown for the first time
that an individual’s testosterone levels
are associated with the choice of col-
ours they make when taking part in
competition. In this study, it was found
that males who chose to wear red in a
competitive task had higher testos-
terone levels than other males who
chose to wear blue.
Dr Daniel Farrelly, a Senior Lecturer in
Psychology believes this may explain
why teams as well as individual sports
stars in red could be much more suc-
cessful than those wearing other col-
ours.
Dr Farrelly, explains: “It has been
shown that in other primates such as
some species of monkeys, the redness
of skin relates to both the individual’s
testosterone levels
and also their domi-
nance. It is possible
that a similar innate
effect may occur in
humans. However it
may also be the result of cultural links
we make with the colour red, as it is
often used in warning signs such as
‘stop’ signs and traffic lights.
Researchers recruited 73 men who
were unaware of the study’s aims, and
told them they would be performing a
competitive task and their performanc-
es would be placed on a leaderboard.
Participants then chose either a red or
blue symbol to represent them in the
table and completed the competitive
tasks. They also answered question-
naires on whether personal reasons
affected their choice, to explain a num-
ber of characteristics about the colour
choice. Saliva samples were taken both
at the start of the study (before they
knew about the
competitive task)
and at the end, and
these were then
analysed for testos-
terone levels.
Dr Farrelly said:
“This is the first
study to look at whether
biological factors, specifical-
ly testosterone which has
been linked to characteris-
tics such as dominance,
aggression and competi-
tiveness, may affect the
choices we make in com-
petitive scenarios. Also by
allowing participants in a
test to choose their colour,
this study reveals that there
may be something intrinsi-
cally different about ‘red’ competitors,
that can give them an advantage.”
Farrelly, D, Slater, R, Elliott, H,
Walden, H and Wetherell, M (2013)
Competitors who choose to be red
have higher testosterone levels.
Psychological Science.
“Research shows for the
first time that an
individual’s testosterone
levels are associated with
the choice of colour in
competition”
Dr Daniel Farrelly, Dept of Psychology
7
Older drinkers need better alcohol advice
RESEARCH NEWS from the Health Sciences and Well-being Research Beacon
Joint research at the University of
Sunderland and University of
Newcastle has called for changes to be
made to the recommended safe levels
of drinking for over 65s and also
special alcohol advice to be made
available for older people.
The call comes as the team from
Newcastle and Sunderland Universities
publish a paper which looks at the
reasons why many older people
continue to drink to levels hazardous or
harmful to their health.
The paper found that many older
people may not recognise they are
heavy drinkers if they don’t see
themselves as dependent and
therefore having a problem.
As part of the study, organised through
Fuse, the Centre for Translational
Research in Public Health, the
academics carried out interviews and
conducted focus groups with 53 men
and women aged between 65 and 90.
They wanted to find out the reasons
why many in that age group drink to
unhealthy levels, and what their
attitudes are.
Many of those interviewed were blasé
about high alcohol intake and
questioned health practitioners who
cautioned them to drink less.
But heavy drinking in this age group is
strongly linked with depression and
anxiety and longer term health
problems.
Metabolism is slower in later life, and
older people are very likely to take
prescribed medicines that can interact
with alcohol. For these reasons heavy
drinking can have a bigger impact on
the lives of older people than the
younger generation.
And so far public health messages
about harmful drinking have not been
as effective for the older age group as
they have for the younger.
Older people saw drinking alcohol as a
positive way to relax and be sociable
with friends and family.
Chronic pain, loneliness and
bereavement were identified as likely
to lead to heavier drinking in later life.
The study was funded by Age UK.
University of Sunderland researchers pictured from L-R: Prof Ann Crosland and Dr Jonathan Ling
Department of Pharmacy, Health and Well-being
G.B. Wilson, E.F.S. Kaner, A. Cros-
land, J. Ling, K.E. McCabe, and
C.A. Haighton, 'A Qualitative
Study of Alcohol, Health and
Identities among UK Adults in
Later Life' PLOS ONE, 8 (2013),
8
New life into heart transplants
RESEARCH NEWS from the Health Sciences and Well-being Research Beacon
Human hearts which are not used each
year because they are deemed
unsuitable for an organ transplant
could get a second chance to save a
life, with the help of new research
taking place in the North East.
Organ shortage is one of the most
pressing issues concerning the field of
transplantation, with hundreds of
Britons a year dying while on the
transplant waiting list, and coronary
heart disease being one of the biggest
killers in the UK.
Some hearts are not retrieved from
potential donors due to their
unsuitability for organ transplantation.
Now new research at the University of
Sunderland, in collaboration with
Newcastle University to restart hearts
and develop tests to prove they are still
viable, could use more of the declined
donor hearts, potentially helping to
reduce transplant waiting lists.
As a result of successful pre-clinical
tests in the lab to get dead pigs’ hearts
beating once again, clinical trials are to
begin on human hearts that would not
otherwise have been used after ethical
approval was granted by National Re-
search Ethics service in Newcastle.
Dr Noel Carter, senior lecturer in molec-
ular biology, explained: “We have
demonstrated enough evidence in our
results from restarting pigs’ hearts after
several hours of being clinically dead, to
be able to begin clinical testing on
human hearts that are considered too
marginal to be used for transplant or as
a source of heart valves.
“Heart surgeons have to be 100%
positive that this vital organ is going to
work before transplantation, which is
why a number of them end up not
being used. Our research wants to take
those rejected hearts, get them
restarted, carry out echocardiograms
and tests in a sterile environment to
check activity and show them to be in
perfect working order. We believe then
a proportion could be reconsidered for
transplantation.”
The research team has developed a
novel circulatory equipment and defib-
rillators to pump warm, oxygenated
blood through the hearts and used
dialysis to filter out unwanted products
from the circuit thereby restoring the
heart’s metabolic activity.
Dr Carter added: “We are devising a
series of parameters to test the hearts
and ensure that they would be viable if
a transplant goes ahead. We believe
this could offer new hope for patients
and see an increase in heart trans-
plants.”
Heart transplant is the only option for
patients with end-stage heart failure or
irreparable coronary artery disease.
During this procedure, doctors replace
the ailing heart with a healthy one from
a brain dead patient.
This latest research is in addition to
previous work by the same Sunderland
research group hoping to expand the
donor pool by looking at
non-heartbeating donors.
“We believe this could offer new hope for patients
and see an increase in heart transplants.”
Left to right: Dr Noel Carter, Dept of Pharmacy, Health and Well-being, with PhD student Omar Mownah
9
Football myth kicked into touch
RESEARCH NEWS from the Health Sciences and Well-being Research Beacon
Barcelona, Bayern Munich and the
Spanish football team might dominate
the beautiful game, but new research
has quashed the myth they tire the
opposition by keeping the ball.
For years, coaches, pundits and fans
believed teams should “let the ball do
the work” because the other team will
have to run further to regain posses-
sion. This is believed to enable world
class players to tire their opponents out
and help them conserve their energy.
However, research from the University
of Sunderland shows they cover the
same distances whether teams have the
ball or not.
Academics looked at 810 English
Premier League players in 54 matches
with an equal amount of players from
home and away sides, with the data
taken from the computerised tracking
system. Each individual player’s physical
and technical performance was
recorded, including how far they ran,
the varying levels of intensity and how
many passes they made.
The research has quashed the myth that
if you pass the ball more often than the
opposition then you would conserve
energy, tiring them out while doing so.
They found that no differences were
observed for total distance covered by
football teams with low percentage of
ball possession and those who had the
ball more often. This trend continued
when it came to high intensity running
and sprinting.
Research showed running with the ball
at a high-intensity was 31 per cent more
by teams with a high percentage of pos-
session than those with a low percent-
age. In contrast, those teams with a
high percentage of possession ran 22
per cent less at a high-intensity than
those with a low percentage when they
did not have the ball.
Dr Paul Bradley, senior lecturer in sport
and exercise science said: “We didn’t
find any statistical difference in their
physical exertions during the game.
However, as expected the technical
indicators did show superior differences
between those that keep the ball, and
those that don’t. The myth is that if you
cover a large amount of distance then
you tend to have a lower percentage of
possession, but these findings show it
isn’t the case at all.
“We always thought that there was
truth in the old adage of ‘let the ball do
the work’ and let the other team chase
after it, but it’s quite clearly not backed
up by the facts. There’s less than one
per cent difference between high and
low percentage of possession football
teams. They’re obviously superior in
terms of how many passes they make,
but not in distance.”
The research is the first to examine the
effects of high percentage of ball
possession and a low percentage on
physical and technical profiles during
elite football matches. The research
also looked at each different position
from each group for comparison.
Bradley P, Lago-Penas C, Rey E and Diaz A G (2013) The effect of high and low
percentage ball possession on physical and technical profiles in English FA
Premier League soccer matches. Journal of Sports Sciences, 31 (12).
Dr Paul Bradley
Dept of Sport and Exercise Sciences
10
Sunderland→London & Australia
Dr Jane Carr-Wilkinson, a senior lecturer in Physiological
Sciences in the Department of Pharmacy, Health and Well-
being gave a presentation at the House of Lords on cancer
research work taking place in the North East.
Dr Carr-Wilkinson was invited to the 25th Anniversary
Science Celebration of Children with Cancer UK, which held
its special reception to showcase the leading edge research
which the charity funds, in June 2013.
Dr Carr-Wilkinson presented a poster based on research,
which she has been working on in collaboration with
Newcastle University, developing a stem cell model that will
aid understanding of how common childhood tumour
neuroblastoma develops.
Dr Carr-Wilkinson said: “By understanding more about how
cancer develops, research may lead us to the development
of much-needed new therapies that may improve the
survival rates for cancer, including high risk neuroblastoma.”
Dr Jane Carr-Wilkinson takes cancer research
from Sunderland to the House of Lords
Linda Váradi’s PhD research to help in the fight against
infections, such as MRSA and E. coli, has led to a prestigious
placement ‘down under’.
Linda Váradi joined the University of Sunderland in 2009 and
began her project to design, make and test compounds to be
used in hospital laboratories to detect and identify the
bacteria responsible for causing infections in patients. This
research is being carried out in collaboration with global bio-
technology company bioMérieux and Newcastle’s Freeman
Hospital, as part of an on-going collaboration.
As a result of this work and her academic experiences at
Sunderland, Linda was offered a three-year postdoctoral
fellowship on a National Health and Medical Research
Council (NHMRC) funded project at the University of Sydney
in Australia.
Linda said: “I’m delighted to have been offered this post; it’s
working as part of a multi-national collaboration with
renowned researchers in their field. I am going to be working
on chemistry research, trying to enhance bacterial detection.
The main aim is to patent some of the applications and have
the research published. This has been made possible thanks
to the skills and scientific understanding I’ve developed at
Sunderland.”
Roz Anderson,
Professor of
Pharmaceutical
Chemistry, said:
“We are delighted
that Linda has been
offered this post,
which attracted
applications from
around the world.”
PhD student takes research ‘down under’
Linda Váradi (right) pictured with her
PhD supervisor Prof Roz Anderson
Dr Jane Carr-Wilkinson pictured outside House of Lords
11
Research funding news: Molplex
Molplex Pharmaceuticals has been conditionally selected to
receive government funding to help deliver new treatments
against the growing menace of drug resistant infections.
The company uses its innovative technology to identify and
optimise new treatments for infections and other serious
diseases.
An award from the Government’s Regional Growth Fund
(RGF) will help to build a new Optiplex drug discovery facility
that will speed up the delivery of new treatments at a radi-
cally lower cost.
Chief Executive Officer David Leahy was delighted to receive
the high level of financial support from the government:
“This success is a major breakthrough for Molplex in our
fight to deliver new drug treatments in a safer, more effec-
tive way and at a much lower cost.
“The award also recognises the hard work we have done
over many years to optimise the pharmaceutical research
and development and will trigger additional private invest-
ment, creating new jobs at Molplex, our suppliers and in the
local community.”
Mr Leahy also thanked other contributors who had helped
with the project.
“We thank our investors and Sunderland University for their
help in getting Optiplex production-ready.
“The University’s practical assistance and “can-do” attitude
has been critical in getting this important work off the
ground.”
The local SME Molplex Pharmaceuticals’ Optiplex platform
fuses in silico drug design and automated decision making
with microscale candidate synthesis and surface plasmon
resonance screening to optimise the drug discovery process,
providing results more quickly and at a significantly lower
cost.
Working alongside Dr Mark Ashton, Dr Peter Dawson and
Prof Roz Anderson at the University of Sunderland, Dr Tim
Blackburn is supported by Molplex to develop and validate
novel microfluidics technology for future Optiplex use.
This new collaboration is already producing interesting and
exciting results, with the promise of publication soon to be
realised.
We applaud Molplex for achieving this award and anticipate
the translation of an exciting concept into clinical products.
Molplex win UK Government funding to establish an Optiplex laboratory
to deliver new drugs for currently untreatable infections
12
Beacon Research Seminars
HSWB BEACON SEMINARS are open to everyone to attend
HSWB Beacon research seminars for 2013-4 include a variety of stimulating and diverse speakers and
topics around the five research themes of the Beacon. Seminars are open to all and refreshments
are served.
New seminars are being added to our series on a continuous basis, so do please check the Beacon
website for an up to date schedule at:
http://www.sunderland.ac.uk/research/areasofresearch/healthsciencesandwell-beingbeacon
If you would like to be added to the seminar email list to receive details of seminars by email, please
contact Glenda Young, FAS Admin Assistant (Research Beacons), email:
glenda.young@sunderland.ac.uk or ext. 2527.
Beacon Publications
May—September 2013
RESEARCH ARTICLES
Bradley PS, Carling C, Gomez Diaz A, Hood, P, Barnes C, Ade J, Boddy M, Krustrup P & Mohr M (2013) Match Performance
and Physical Capacity of Players in the Top Three Competitive Standards of English Professional Soccer. Hum Mov Sci.
Bradley PS, Di Mascio, M, Bangsbo, J & Krustrup, P. (2012b) The maximal and sub-maximal versions of the Yo-Yo inter-
mittent endurance test level 2 are simply reproducible, sensitive and valid. Eur J Appl Physiol 112, 1973-1975.
Bradley PS, C. Lago-Penas, E. Rey, and A.G. Diaz, The Effect of High and Low Percentage Ball Possession on Physical and
Technical Profiles in English FA Premier League Soccer Matches, J Sports Sci., 31 (2013 ), 1261-70.
Bradley, PS, and P. Krustrup, Counter-Point Number 3: Football-Specific Testing: Adding Value or Confirming the Evidence?,
The Journal of Sports Sciences, epub ahead of print (2013).
Bradley PS & Noakes TD (2013) Match running performance fluctuations in elite soccer: indicative of fatigue, pacing or situ-
ational influences? J Sports Sci.
Carling C, Nelson L, Wright M & Bradley PS (2013) Comment on ‘Performance analysis in football: A critical review and im-
plications for future research’ J Sports Sci. .
Di Mascio M & Bradley PS (2013) Evaluation of the most intense high-intensity running period in English FA premier league
soccer matches. J Strength Cond Res 27, 909-915
Gomez-Diaz A, Pallares JG, Diaz A & Bradley PS (2013). Cuantificación de la carga física y psicológica en fútbol profesional:
diferencias según el nivel competitivo y efectos sobre el resultado en competición oficial. Revista de Psicologia del Deporte.
22, 201-207.
13
Beacon Publications
RESEARCH ARTICLES continued
Bradley, P.S., Dellal, P.S., Mohr, M. Castellano, J & Wilkie, A. (2013 E-pub ahead of print). Gender Differences in Match Per-
formance Characteristics of Soccer Players Competing in the UEFA Champions League. Human Movement Science.
Brierley-Jones, L., Crawley, R.A., Ayers, S. and Lomax, S. (2014 in press) Stillbirth and Stigma: The Spoiling and Repair of
Multiple Social Identities, OMEGA the journal of death and dying
Coad, L, Carter, N and Ling, J (2013) Attitudes of young adults from the UK towards organ and tissue donation and trans-
plantation. Transplantation Research, 2:9.
Crawley, R., Lomax, S. and Ayers, S. (2013) Recovering from stillbirth: The effects of making and sharing memories on ma-
ternal mental health. Journal of Reproductive and Infant Psychology
Wilson, G B, Kaner, E F S, Crosland, A, Ling, J, Smith, K and Haighton, C A (2013) A Qualitative Study of Alcohol, Health and
Identities among UK Adults in Later Life. PLoS ONE 8(8): e71792.
Cuthill, F. (2013 in press) Understanding the ways in which health visitors manage anxiety in cross-cultural work: a qualita-tive study, Primary Health Care Research and Development.
Haj-Ahmad, R. R., Elkordy, AA, Chaw, CS, Moore, A. (2013). Compare and contrast the effects of surfactants (Pluronic®F-127
and Cremophor®EL) and sugars (β-cyclodextrin and inulin) on properties of spray dried and crystallised lysozyme. European
Journal of Pharmaceutical Sciences. 49: 519-534.
Elkordy, AA., Bhangale, U., Murle, N., Zarara, M. F. (2013). Combination of lactose (as a carrier) with cremophor® EL (as a
liquid vehicle) to enhance dissolution of griseofulvin. Powder Technology. 246: 182-186.
Farrelly, D. (2013) Altruism as an Indicator of Good Parenting Quality in Long Term Relationships: Further Investigations
Using the Mate Preferences Towards Altruistic Traits Scale, The Journal of Social Psychology, 153, 395-98.
Bedernjak, A., Groundwater, PW, Gray, M, Orenga, S, Perry, JD, Anderson, R. (2013) Synthesis and Evaluation of Halogenat-
ed Nitrophenoxazinones as Nitroreductase Substrates for the Detection of Pathogenic Bacteria Tetrahedron, 69, 8456–62.
Todd, A., Husband, A., Hurren, A., Kler, S. & Ling, J. (2013). Patients using antifungals following laryngectomy: A qualitative
study of community pharmacists in the North of England. International Journal of Pharmacy Practice 13 (1): 45 - 49.
Ling, J., McCabe, KE, Brent, S. & Crosland, A. (2013). Key workers in cancer care: Patient and staff attitudes and wider impli-
cations for role development in cancer services. European Journal of Cancer Care 22 (5), 691-698.
Vaideanu, D., Sandhu, S.S., Ling, J., Richardson, J. & Steel D.H.W. (2013 in press). The rate of diabetic vitrectomy in a defined geographical area of North East England. Ophthalmic Epidemiology.
M. Ahsan, H. Nazar. An investigation of how personal smoking habits affect a healthcare professional’s (HCPs) ability and
motivation to provide effective smoking cessation advice and consultation: Perspectives of undergraduate pharmacy stu-
dents. International Journal of Pharmacy Practice (2013) Supplement 2; 21:24-25.
I. Andrew, H. Nazar. A palliative care (PC) hospice placement: Students’ qualitative evaluation of experience-based learning.
International Journal of Pharmacy Practice (2013) Supplement 2; 21:39.
N. Ahmad, H. Nazar. Investigating the views of undergraduate pharmacy students towards physician assisted suicide (PAS).
International Journal of Pharmacy Practice (2013) Supplement 2; 21:40.
A. Todd, H. Nazar, I. Andrew, L..Baker, A. Husband. Quantification of drug-related toxicity associated with the prescribing of
inappropriate medicines for patients with limited life expectancy. International Journal of Pharmacy Practice (2013) Supple-
ment 2;90-91.
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Beacon Publications
RESEARCH ARTICLES continued
Roberts J, Crosland A, Fulton J (2013 in press) “I think this is maybe our Achilles Heel....” Exploring GPs’ responses to young
people presenting with emotional distress in general practice. A qualitative study. Biomed Central.
Wilkie, S and Stavridou, A (2013) Influence of Environmental Preference and Environment Type Congruence on Judgments of
Restoration Potential. Urban Forestry & Urban Greening, 12. pp. 163-170
BOOKS, BOOK SECTIONS, EDITED BOOKS
Anderson, RJ and Todd, A. Chapter 3: Stereochemistry in Drug Action, , in ‘Integrated Foundations of Pharmacy: Pharma-
ceutical Chemistry’ by Barber and Rostron, Oxford University Press.
OTHER PUBLICATIONS
Alderton, W.K., Anderson, RJ, Collingwood, S.P., Pryde, D.C. Therapeutic Opportunities in Infectious Diseases: Highlights
from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, Lon-
don, UK, Drugs of the Future, 2013, 38(5): 347.
Dodou K, Whiteley P (2013) In search of biomarkers - the science of metabolomics in pharmacy. The Pharmaceutical Jour-
nal; 290:512-513.
Dodou K and Whiteley P (2013) Lipidomics - the Science and Study of How Lipids Affect and Modify Our Health, Pharmaceu-
tical Journal, 291, 23-24.
Hayes, C. (2013) Dispelling myths about ageing for healthcare assistants, British Journal of Healthcare Assistants, 7,(7), 328-
334
Hayes, C. (2013) Mentorship in Action for Healthcare Assistants, British Journal of Healthcare Assistants, 7,(5), 252-255.
Nazar, H. (2013) Developing biomaterials for tissue engineering and regenerative medicine. Pharmaceutical Journal. Sept 2013.
Nazar, H. (2013) Using 'smart' biomaterials and systems for targeted drug delivery. Pharmaceutical Journal. June 2013.
CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS
Brierley-Jones, L., Crawley, R.A., Ayers, S. and Lomax, S. (2013) Stillbirth and Stigma: The Spoiling and Repair of Multiple
Social Identities, in BSA 45th Medical Sociology Annual Conference, University of York, UK,
Jill Jobson, Noel Carter, Ken McGarry, Achim Treumann and Roz Anderson A Quantitative Proteomic Investigation of Cysti-
notic Fibroblasts and Proximal Tubule Epithelial Cells using SILAC, , Poster Presentation, Cystinosis Research Network Con-
ference (Washington D.C., USA), July 2013.
M. S. Chu, and C. S. Chaw, Ketoprofen Loaded Pellets Produced by Extrusion/ Spheronisation Using Avicel Cl611 as Spheron-
isation Aids in UKPharmSci conference, 4th September 2013 .
V. J. Li-Kwok-Cheong, and C.S. Chaw, The Behaviour of Xanthan Gum Matrix Systems, in UKPharmSci conference 2013.
Dodou, K. (2013) Surface dissolution imaging on Pluronic F127 gel formulations containing ibuprofen. 3rd Annual Dissolu-
tion Symposium, 3rd-4th June 2013 (University of Bath)
Eng, M., Haj-Ahmad, R.R., Elkordy, AA. (2012). Characterisation of DNA in the presence of excipients. Poster presentation at
the UK- PharmSci 2012 conference, September 12-14th, 2012 in Nottingham, UK.
15
Beacon Publications
CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS continued
Elkordy, AA. (2012). When will liquisolid tablets as dosage forms for enhancement dissolution of hydrophobic drugs be
available in the market? Poster presentation at 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceuti-
cal Technology, Turkey, Istanbul, 19th – 22nd March 2012.
Elkordy, A.A. Evaluation of different Floating Tablets at Target meeting's Third World Drug Discovery Online Conference,
15th - 17th October 2013.
Elkordy, A.A. Folding reversibility of lysozyme in the presence of poly vinyl pyrrolidone at 2nd Central and Eastern European
Conference on Thermal Analysis and Calorimetry, 27th - 30th August 2013, Vilnius, Lithuania
Elkordy, AA. Correlation of folding reversibility with biological activity: Lysozyme and Trypsin in crystallised and dried forms
Presented on 10th April 2013 at the TAC 2013 conference “Modern Thermal Methods from an Industrial and Academic
Perspective” (9th - 10th April, 2013), University of Greenwich, Chatham, UK.
Haj-Ahmad, R.R., Chaw, C.S., Elkordy, A.A., Moore, A. (2013). Stabilizing effect of surfactants and saccharides on freeze
dried lysozyme. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.
Javaheri, H., Elkordy, A.A., Carter, P. (2013) Preparation and Evaluation of Liquisolid Compacts Containing Salbutamol Base
with PEG 400 and Synperonic® PE/L44. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013
in Edinburgh, UK.
Loh, Z., Elkordy, A.A. (2013). Preparation and Characterisation of Metronidazole Floating Tablets. Poster presentation at
the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.
Rusby, N., Elkordy, A.A. (2013). Influences of Poly-vinyl pyrrolidone and Pluronic® F127 on Lysozyme Folding Reversibility
and Biological Activity. Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh,
UK.
G. O'Boyle, (2013) A Small Molecule Agonist of the Chemokine Receptor Cxcr3 Prevents Experimental Graft-Versus-Host
Disease, in “The Leading Edge of Leukocyte Migration”, the inaugural meeting of the British Society of Immunology Leuko-
cyte Migration Group, Glasgow.
C. Wassef, I. Andrew, T. Paget, H. Nazar. Sedative drug prescribing practices at a local Hospice at the end-of-life compared to current guidelines. UK Clinical Pharmacy Association 2013. Harrogate.
A. Todd, H. Nazar, I. Andrew, A. Husband Prescribing of inappropriate medication in patients with limited life expectancy: a prospective study in a specialist palliative care unit. UK Clinical Pharmacy Association 2013. Harrogate. Won Patient Safety Award.
A. Todd, H. Nazar, I. Andrew, A. Husband. Quantification of drug-related toxicity associated with the prescribing of inappro-priate medicines for patients with limited life expectancy. Royal Pharmaceutical Society Conference 2013. Birmingham.
N. Ahmad, H. Nazar. Investigating the views of undergraduate pharmacy students towards physician assisted suicide (PAS). Royal Pharmaceutical Society Conference 2013. Birmingham.
I. Andrew, H. Nazar. A palliative care (PC) hospice placement: Students’ qualitative evaluation of experience-based learn-ing. Royal Pharmaceutical Society Conference 2013. Birmingham
M. Ahsan, H. Nazar. An investigation of how personal smoking habits affect a healthcare professional’s (HCPs) ability and motivation to provide effective smoking cessation advice and consultation: Perspectives of undergraduate pharmacy stu-dents. Royal Pharmaceutical Society Conference 2013. Birmingham.
16
CONFERENCE WATCH— PROCEEDINGS, PAPERS AND POSTERS continued
Suliman, A.S., Anderson, R.J., Elkordy, A.A. (2013). Liquisolid Tablet Preparation for Norfloxacin Dissolution Enhancement.
Poster presentation at the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.
Wong, L.M., Elkordy, A.A. (2013). Improvement of dissolution of Ibuprofen via in-situ lyophilisation. Poster presentation at
the UK-PharmSci 2013 conference, September 2nd - 4th, 2013 in Edinburgh, UK.
Wilkie, S., Tan, Q., O’Lynn, J. (2013, June). More than bricks and mortar: Determining how the psychological qualities of
home places influence resident well-being. Environmental Design Research Association 44th Annual Conference, Provi-
dence R.I.
Wilkie, S., & Stavridou, A. (2013, June). Influence of environmental preference and environment type congruence on judge-
ments of restoration potential. Poster presented at the Environmental Design Research Association 44th Annual Confer-
ence, Providence R.I.
REPORTS
Cuthill, F., Abdalla, O.S. and Bashir, K. (2013) Between destitution and a hard place: finding strength to survive refusal from
the asylum system: a case study from the North East of England. Sunderland: University of Sunderland.
Health Sciences and Well-being Research Beacon
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