h.gaub / ss 2007bpz§4.31 all pore-forming ion channels are similar in structure

H.Gaub / SS 2007 BPZ§4.3 1

All pore-forming ion channels are similar in structure

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Struktur des K-Kanals

Rod MacKinnon

Chemie Nobelpreis 2003

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Crystal is defined and stabilized by Antibodies

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Chemistry of Ion Coordination and Hydration Revealed by a K+ Channel-Fab Complex at 2.0 Angstrom Resolution; MacKinnon, R., et al.; Nature, Vol. 414; January 1, 2001

Potassium Channel Receptor Site for the Inactivation Gate and Quaternary Amine Inhibitors; MacKinnon, R., et al.; Nature, Vol. 411; March 8, 2001

Energetic Optimization of Ion Conduction Rate by the K+ Selectivity Filter; MacKinnon, R., et al.; Nature, Vol. 414; November 1, 2001

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Ionenselektivität des Natriumkanals

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Alternative Stacking of K+ (Green) and Water (red)

High K+ Concentration (2M)

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Gating by conformational changes of the tetramer