i. pavlik mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in...

I. Pavlik

Mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in human population in

Central European countries during the years 1990 to 1999

Veterinary Research Institute, Brno, Czech Republic

Mycobacterium tuberculosis complex:

• M. tuberculosis • M. africanum• M. bovis• M. bovis BCG• M. bovis subsp. caprae (M. caprae) • M. canettii • M. microti• M. pinnipedi

Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf

M. tuberculosis H37Rv

M.africanum

M. tuberculosisManila genotype

M. tuberculosisBeijing genotype

M. bovis BCG

M. bovis

M. bovis subsp. caprae

M. bovis subsp. capraeM. bovis subsp. caprae

M. tuberculosisseal genotype

M. microti type vole

M. microti type Ilama

M. canetti

M. bovis

Spoligotypes of members of M. tuberculosis complex

Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf

Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf

Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf

(10.3 mil.)

Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

Pavlik et al., Vet. Med. Czech, 2003, 90-98.

(5.4 mil.)

Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

Pavlik et al., Vet. Med. Czech, 2003, 90-98.

(4.5 mil.)

Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

Pavlik et al., Vet. Med. Czech, 2003, 90-98.

(2.0 mil.)

Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

Pavlik et al., Vet. Med. Czech, 2003, 90-98.Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf

M. tuberculosis v tuberculous lesions in pigs

• Norway 1970-1975: 3 004/+ 3 (0.1%), Flesja et al., 1978

• England 1953-1968: 626/+67 (10.7%), Lesslie and Birn,

1970

• USA 1973-1977: 2 036/+ 1 (0.01%), Thoen et al., 1981

• BRD 1961-1970: 2 055/+ 10 (0.49%), Schliesser, 1976

• Slovakia 1972: 1 421/+ 1 (0.07%), Popluhar et al.,1974

• Total: 9 142/+ 82 (0.90%)

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Cited references see in paper:

M. tuberculosis v tuberculous lesions in cattle

• BRD 1961-1970: 1 135/ + 2 (0.20%) Schliesser, 1976

• Slovakia 1970: 553/ + 1 (0.18%) Popluhar et al., 1970

• England 1953-1968: 14 439/ +13 (0.09%) Lesslie and Birn, 1970

• USA 1973-1977: 7 007/ + 1 (0.01%) Thoen et al. 1981

• Total: 23 134/ +82 (0.90%)

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Cited references see in paper:

M. tuberculosis v tuberculous lesions in wild animals

• USA: 29 (6.1%) from 474 nonhuman primates and wild ruminants

(Thoen et al., 1981).

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Cited reference see in paper:

Sources of infection for animalsOld visitors

Purchased infected animals

13

17

1990-1999 13

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Animals in zoological garden Gdansk in Poland infected with M. tuberculosis

(1990-1999)

African elephant (Loxodonta africana) 1 1997

Agouti (Dasyprocta aguti) 1 1997

Tapir (Tapirus terrestris) 1 1999

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Sources of infection for animals

Infected man excreting causal agent of human tuberculosis by:

• sputum, • less often urine, or • faeces.

(Thoen and Steele, 1995; Grange, 1996).

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Cited references see in paper:

External environment – source of infection?

• In Slovakia M. tuberculosis was isolated from river water with waste water from tuberculosis hospital

(Laktis et al., 1970).

Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf

Cited reference see in paper:

Thank you for your attention