iba particle therapy bu damien prieels, research manager
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A reference Monte Carlo platform to assess radiation
quality in hadron therapy (protons & carbon ions).
IBA Particle Therapy BU
• Damien Prieels, Research Manager
• Damien Bertrand, Research Project Manager
Creatis-LRMN RIO Team
• David Sarrut, CNRS Researcher (PhD Director)
• Nicolas Freud, Assistant Professor
Loïc Grevillot PhD Student
ENLIGHT-PARTNER
Valencia IFIC 19/06/09
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Presentation Plan
Introduction Geographical context Goal of the project
Overview of the project Imaging & computing Irradiation system Validation
Conclusion Limitations of the project Status from January 2009 Early results
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Geographical context
ESR @ IBA, LLN, BelgiumETOILE, Lyon, France as a secondary partner
Léon Bérard Cancer CentreCreatis-LRMN lab
IBA
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Goal of the project
To be able to compare treatment plans from a commercial Treatment Planning System (TPS), with Monte Carlo (MC) simulations, for proton and carbon ion beams, focusing on active beam delivery.
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Overview of the project
Be able to compare treatment plans from a commercial TPS with my MC simulations, for protons and carbon ions beam, for active beam delivery only.
The research tool developed should be able to compute output relevant to radiobiology.
• Ray tracing• Pencil beam• Others ?
• Bragg peaks• SOBP• Spot size• Energy spread• etc. ?
• Energies• Intensities• Directions
• Beam
VA
LI
DA
TI
ON
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Overview of the project
Proton: “easy”:
• A lot of centres and experience
• Data are accessible for validation
• Commercial TPS exist
Carbon ions “real research begins”:
• Less centres and experience
• Less fundamental data accessible
• Need to merge biology within physics simulations
• No commercial TPS accessible
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Overview of the project
dd Imaging & Computing part
The irradiation system
Validation part
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Limitations of the project
Radiobiological models implementation• German model (LEM)• Japanese model• Czech Republic model• Other models?
Fundamental data limits• Carbon fragmentation• RBE uncertainty• Uncertainty on the ionizing
potential of water & human tissues
Collaborations are welcome!
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Status from January 2009
Working on protons only:
• Looking at the physics list
• Looking at the relevant parameters
=> First interesting results are waiting for validation against
measurements, that should be done this summer.
Objectives:
• To validate proton simulations.
• To simulate a proton plan with the Gate MC platform.
• To extend to carbon beams & address radiobiological issues.
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Early results
0 1 2 3 4 5 60
0,2
0,4
0,6
0,8
1
1,2
69 MeV proton beam
Geant4-69MeVMesureGeant4-69MeV-DeltaE1%
Depth in water (cm)
Rel
ati
ve d
ose
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Early results
0 5 10 15 200
0,2
0,4
0,6
0,8
1
1,2
164 MeV proton beam
Geant4-164MeVMesureGeant4-164MeV-DeltaE0,50%
Depth in water (cm)
Rel
ativ
e do
se
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Early results
0 5 10 15 20 25 30 35 40 450
0,2
0,4
0,6
0,8
1
1,2
231 MeV proton beam
Geant4-231MeVMesureGeant4-231MeV-DeltaE0,40%
Depth in water (cm)
Re
altiv
e d
ose
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This work is performed within the PARTNER research programme, with financial support from the European Commission
(FP7-People/ITN Grant nr. 215 840).
Thank you!
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The computing part
dd
Computing & research part
Research part
• Energies• Intensities• Directions
• Medium• Stopping Power
Imaging & Computing part
• Beam:
• HU to convert into :
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The irradiation system
dd Computing part
Research part• Bragg peaks• SOBP• Spot size• etc. ?
The irradiation sytem
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The validation part
dd Computing part
Computing & research part
Validation part
• Gate/Geant4• Physics list
• Electromagnetic & Hadronic • Relevant parameters of a simulation
• Cut, Step size, ..., others?• Accuracy/Efficiency compromise
• Radiobiological models implementation
• Beam quality assessment:• LET by particle nature• Energy spectrum by particle nature• Particle spectrum in the medium• Biological dose calculation
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Status: early results , the cut parameter230 MeV proton beam.
315 320 325 330 335 340 345
0,00E+000
5,00E-002
1,00E-001
1,50E-001
2,00E-001
2,50E-001
1 mm0,5 mm0,2 mm0,1 mm0,05 mm0,02 mm0,01 mm0,001 mmMCNPX
6 mmcut 1 mm
cut 1 µmcut 0,1 mm
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Status : early results
e-e-
High cut e-
e-
e-
e- e-
e-e-
e- Low cut
e-e-e-
e-
High cut => high step => lower accuracy Low cut => lower step => better accuracy, but time issues
step
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0,001 0,010 0,100 1,000
328
329
330
331
332
333
334
335
Range of a 230 MeV proton beam
NIST(CSDA approximation)GateMCNPX
Cut (mm)
Ran
ge (
mm
)
5,8 mm
0,001 0,010 0,100 1,000
1,00%
10,00%
100,00%
Time dependance with cut
T ime Ratio
Cut (mm)
Re
lativ
e ti
me
Status: early results , the cut parameter230 MeV proton beam.
Time issues
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