is fast food addictive?
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Is fast food addictive?
Robert H. Lustig, M.D., M.S.L.Division of EndocrinologyDepartment of PediatricsUniversity of California, San Francisco
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PET [11C]raclopride
High
Low
Bonnet macaquesHuman
Autoradiography
[3H]spiperone
BMI = 42BMI = 50 Weight = 650 g
BMI = 23BMI = 23 Weight = 400 g
Zucker rat2
1Wang et al. J Nucl Med. 49(Suppl 1):208P, 2008; 2Thanos et al. Synapse. 62:50, 2008
Stimulates Glut4 mRNA and protein
Stimulates Acetyl-CoA Carboxylase
Stimulates Fatty Acid Synthase
Stimulates Lipoprotein Lipase
Hypothalamic actions inhibits lipolysis by suppressing SNS tone and Hormone-Sensitive Lipase
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Scherer et al. Cell Metab doi10.1016/j.cmet.2011.01.008
Direct effects on the reward system:
Is sugar (fructose) addictive?
Garber and Lustig, Curr Drug Abuse Rev 4:190, 2011
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Sweet-Ease increases endogenous opioids to reduce pain,Even in neonates
UCSF Weight Assessment for Teen and Child Health (WATCH)Andrea Garber, Ph.D., R.D.Patrika Tsai, M.D., M.P.H.Stephanie Nguyen, M.D. M.A.S.Emily Perito, M.D.Jung Sub Lim, M.D., Ph.D.
Touro University Dept. of BiochemistryJean-Marc Schwarz, Ph.D.
San Francisco General Hospital Depts. of Medicine and RadiologySanjay Basu, M.D., Ph.D.Susan Noworolski, Ph.D.Kathleen Mulligan, Ph.D.
UC Berkeley Dept. of Nutritional Sciences and Integrative BiologyPat Crawford, R.D., Ph.D.Paula Yoffe, B.S.
St. Jude Children’s Research HospitalTom Merchant, D.O., Ph.D.Melissa Hudson, M.D.Pam Hinds, R.N., Ph.D.Pedro Velasquez-Mieyer, M.D.
University of Florida Dept. of PsychologyNicole Avena, Ph.D.
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