kilo lab-vacuum dryers and centrifuges

HEINKEL Filtering Systems

Centrifuge and Vacuum Drying Technology – Kilo-lab/Pilot Plant

Presented to:

Date:

Presented by: Tom Patnaik

The Inverting Filter Centrifuge

Pharmaceutical - Fine Chemical Process Equipment

Kilo Lab Dryer Portable Unit R&D Peeler Pilot Dryer

cGMP Peeler Pilot Vertical Inverting Filter cGMP Vertical

Chemical Basket Production Peeler Dryer Production Vertical

Pilot Plant Centrifuge Applications Different types of centrifuges with variable basket diameters offer the

Operator a wide variety solutions for Pilot applications

Heinkel Pilot Plant centrifuges are designed to be flexible according to production and installation requirements in Pilot Plant Labs

Centrifuges with small basket diameters are mainly used in Kilo Labs and small production facilities

HEINKEL fulfils the strict requirements regarding equipment quality, acceptance tests and documentation for Pilot Plant machines

HEINKEL Pilot Plant centrifuge technology is ideal for Product Transfer through out the development phase

Excellent Data Logging Capabilities and Features

Basics of Cake Filtration

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Intrinsic Moisturecannot be removed

mechanically

Pendular Moisturecan be removed under

high G-Forces

CapillaryMoisture

Bowl Wall

Surface-moisture

Drying:Surface < 36°CCapillary 100°CInherent > 150°C

Filter Cloth

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Selecting the Proper Centrifuge for Multi-Product Environments

cGMP ProcessVertical

Basket Top Unloading

Vertical Basket

Bottom Discharge

Horizontal Peeler

Inverting Filter / PAC

•Easy-to-filter materials• Low containment

• Low risk of exposure• Manual operation

•Easy-to-filter materials• Automatic discharge

• Low Risk of Exposure• Higher Throughput

• Medium to Slightly Difficult Filtering

• Residual Heel Issues!• Higher Containment• Improved Washing

Efficiency

• Most Versitale Centrifuge•Difficult to Easy Filtering

• No Residual Heel• High containment

• Ideal for Multiple Products• Best Wash Efficiency

Vertical Centrifuge Interchangable Bowls

Technical Data V 200 V 300 V 400

Basket diameter [mm] 200 300 400

Basket height [mm] 100 150 250

Filter area [m²] 0.062 0.14 0.31

Nominal volume [l] 1.5 4.9 16

Max. load [kg] 2.0 8.0 20.0

Max. speed [rpm] 4,200 3,000 2,000

Max. g-force [-] 1,960 2,055 900

Multi-Purpose Application Automatic recognition of the basket size Jacketed housing for cooling or heating

Basket diameter 200mmBasket diameter 300mmBasket diameter 400mm

Filtering Basket / Removable Lip

Portable Vertical Basket• Mobile

Plug-In Power

The vertical machines can be Table Top or Cart Mounted design

Technical Details / Connections

Filtrate discharge

Feed pipe

Wash pipe

CIP N2 – purge out

N2 – purge in

Control air

Electrical connection

Light glass

Sight glass

Over-Flow Solid-BowlApplication:

• Clarifying of liquids if solids fraction tends to settle quickly

Process requirement:• The s.g. of the solids must be higher than the s.g. of the liquid

Steps:• Slurry is fed into the bowl

• The products slowly flows down inside feed cone & migrates across bottom of basket and up the sides

• Solids can be removed manually – or - back flushed

Sedimentation Basket

•Application: Clarifying of liquids• Processes that require longer spinning

times compared to Overflow Basket are required or if solids concentration in the feed is high.

• Process Requirement and Functionality are similar to Overflow Basket

•Intended for longer spin-times

Skimming Tube Solid-Bowl

Application:• Separation of two liquids with different s.g. in a continuous process

Steps:• Feed enters bowl via ditribution cone.

• The liquid with the higher s.g. is skimmed with the upper skimming pipe.

• The liquid with the lower s.g. is skimmed with the lower skimming pipe.

Selecting the Proper Centrifuge for Multi-Product Environments

cGMP ProcessVertical

Basket Top Unloading

Vertical Basket

Bottom Discharge

Horizontal Peeler

Inverting Filter / PAC

•Easy-to-filter materials• Low containment

• Low risk of exposure• Manual operation

•Easy-to-filter materials• Automatic discharge

• Low Risk of Exposure• Higher Throughput

• Medium to Slightly Difficult Filtering

• Non Compressing Heel • Higher Containment• Improved Washing

Efficiiency

• Most Versitale Centrifuge•Difficult to Easy Filtering

• No Residual Heel• High containment

• Ideal for Multiple Products

New TechnologyHeinkel Kilo Lab Peeler Centrifuge

250mm - 320mm Bowl

New TechnologyHeinkel Kilo Lab Peeler Centrifuge

250mm - 320mm Bowl

Technical Data

H 250 H 320

Basket Diameter 250 mm 320 mm

Basket Depth 120 mm 65 mm

Filter Area 0.098 m² 0.065 m²

Nominal Volume 2.5 L 3.38 L

Max. Load 3.1 kg 5.0 kg

Max. Basket Speed

3,800 RPM 3,350 RPM

Max. G-force 2,020 2,000

cGMP Horizontal Peeler Centrifuge

H 500 – H 630Technical

DataH 500 H 630

Basket Diameter

500 mm 630 mm

Basket Depth 250 mm 315 mm

Filter Area 0.39 m²0.62 m²

Nominal Volume

20 l 42 l

Max. Load 25 kg 53 kg

Max. Basket Speed

2.670 RPM

2.400 RPM

Max. G-force 2.000 1900

H 500 – Roche, Basel Switzerland

Selecting the Proper Centrifuge for Multi-Product Environments

cGMP ProcessVertical

Basket Top Unloading

Vertical Basket

Bottom Discharge

Horizontal Peeler

Inverting Filter / PAC

•Easy-to-filter materials• Low containment

• Low risk of exposure• Manual operation

•Easy-to-filter materials• Automatic discharge

• Low Risk of Exposure• Higher Throughput

• Medium to Slightly Difficult Filtering

• Non Compressing Heel • Higher Containment• Improved Washing

Efficiiency

• Most Versitale Centrifuge•Difficult to Easy Filtering

• No Residual Heel• High containment

• Ideal for Multiple Products

What is PAC?PAC stands for Pressure Added Centrifugation. This system allows the Heinkel Inverting Filter

Centrifuge to further dewater and even dry products in the bowl of the centrifuge by introducing pressure up to <6-bar before the solids are discharged - while still under rotation.

Pressure Added Centrifugation = PAC®

FC

FS

FC

FS

FC

FS

pCapillary Forces

Centrifugal Forces

p p

seal betweenfeed pipe androtating bowl

Nitrogen withup to 6 bar

rotational speedcan be reducedduring pressurestep!

PAC® also Improves Cake Consistency

Before PAC – Paste Like After Pac – Solid Product

► Difficult-to-filter products can be dewatered►Products will not stick to the Solids Housing► No cannon-balling in dryers

6 bar

PAC can also improve the cakeconsistency, e.g. thyrotrophiccakes, which may stick onthe Solids Housing.

Pressure-Added-Centrifugation(PAC) to pre-dry the filter cake. Will avoid problems coming From discharging a “wet” cake.

.Test with standard centrifugation (no PAC !!) LOD > 55 % LOD

Wet and Sticky Products = Product Loss

Test with Pressure Added Centrifugation: LOD = 20%

Surface Moisture Removed = Higher Throughput and Profitability (minimal product loss)

Filling

Suspension

`

toFiltrate-receiver

Washing

Wash liquid

toFiltratereceiver

Spinning – Cake dewatering

ToFiltrate-receiver

Filling Washing Spinning Discharging

HypercentrifugationPressure Added Centrifugation PAC®

≤ 6 bar

To Filtrate

Receiver

Vent of BowlNitrogen

Real Pressure Added Centrifugationis only possible with theHEINKEL Inverting Basket!

Discharging of Filter CakeFilling Washing Spinning Discharging

Inverting Filter Discharge

Pressure Added CentrifugationPAC® — Examples

Product nameResidual moisture

centrifugationResidual moisture with PACHYPERCENTRIFUGATION®

Antiallergical Substance

Alkaloid

Food Additive

Metal Powder

Silicon Carbide

Vitamin

30 %

45 %

22 %

26 %

19 %

39 %

11 %

32 %

5 %

12 %

6 %

24 %

► PAC reduces significantly the residual moisture! ► Inverting Filter Centrifuges is the only type which

can operate with pressure centrifugation!

The PAC Difference

API after Discharge without PAC

API after Discharge with 20 minutes of PAC at 100 deg. C

Compact F-Series Inverting Filter Centrifuge

Heinkel F-Series Inverting Filter Centrifuge

Ideal for Existing Plant Equipment Upgrades

• Small Foot Print• Fewer Parts• Faster Rotation Speeds• Functional Clean Room Design

References

CustomerYear of

CostructionType MOC Basket Area

Alessa Chemie

Frankfurt, D2006

HEINKEL GFTV 400-O

316 SS Vertical Explosion-proof

Sanofi-Aventis

Neuville, F2007

HEINKEL GFTH 250

316 SS Horizontal Explosion-proof

PDC VerfahrenstechnikGrambach, A

2007HEINKEL GFT

V 300-O316 SS Vertical Explosion-proof

TEVA

Valby, DK2007

HEINKEL GFTV 300-O

316 SS Vertical Explosion-proof

Roche AG

Penzberg, D 2007

HEINKEL GFTV 400-O

316 SS VerticalExplosion-proof

Roche AG

Basel, CH2006

HEINKEL GFT

V 200-OHC 22 Vertical

Non explosion-proof

Roche AG

Basel, CH1998

HEINKEL GFT

H 500HC-22 Horizontal

Explosion Proof

New TechnologyBolz MiniDry

New Concept of a Kilo Lab Mixer - Dryer

Vessel and Cover welded or made by milling

Orbit arm welded or made by milling

Mixing screw welded or made by milling

Challenge

Milling from one piece

welded

Milling from one piece

Hybrid Agitator

Interchangeable Mixing Tools

- Orbiting Arm Mixing Screw

- Central Shaft - Helical

Low Investment Cost

Evaluation / Comparison ofDifferent Mixing Devices

2 in 1

Realization of trials: Phase IIII: Testing the BS-miniDRY®

with a special Hybrid mixing tool

Bolz MiniDry Interchangeable Mixing Devices

Central Shaft Helical Orbital Arm – Rotary Screw

Suitable for

• Research

• Development

• Optimization

• Small Product Volume

• 150ml to 1500ml

• Data Recording

Application & Process

• Drying

• Mixing

• Moistening

• Granulating

• Homogenizing

• Product Transfer

Markets

• Pharmaceutical

• Fine Chemical

• Chemical

• Food

• Cosmetics

• Minerals

• Metals

• Others

MiniDry Applications and Markets

Thank You For Your Attention

HEINKEL Filtering Systems520 Sharptown Rd

Swedesboro, NJ 08085856-467-3399

www.heinkelusa.com