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Pharma Bio World44 ◄ November 2018 Pharma Bio World November 2018 ► 45

Launch of Romaco’s new blister lineRomaco Noack NBL 400 blister lineRomaco’s new Noack NBL 400 blister l ine was specif ical ly designed to meet the needs of the Asian pharmaceutical markets. With an output of 400 blisters and up to 300 cartons per minute, this durable l ine is ideal for medium batch sizes. An integrated solution comprised of a bl ister machine with rotary sealing and a continuous motion cartoner, i t is very easy to use. Machine operators require no special ist technical know-

solid products. What’s more, nearly al l format parts of the Noack 921 blister machine, which is f irmly established in the market, are also compatible with Romaco’s new Noack NBL 400 blister l ine. Here, too, the new blister technology convinces with outstanding versati l i ty and excellent value for money.

Regarding product feeding, the Noack NBL 400 allows very flexible configurations. Tablets and capsules

processing any standard thermoformable laminate and can also be employed in the manufacture of aluminium-aluminium blisters. Romaco trusts in BlisterMagic, its innovative software solution, to design the cavity geometries and develop individual packaging layouts. This innovative tool provides a very quick and easy route to customise blister packaging. Users of the Noack NBL 400 blister packaging line also profit from Romaco’s expert support when it comes to packaging designs.

Romaco Noack NBL 400 blister line

Romaco Macofar MicroMaxX 18 microdosing machine

how to work on the blister packaging l ine and carry out product and format changes. That is why the robust Noack NBL 400 is also recommended as an entry level model for contract packers and pharmaceutical manufacturers seeking to expand their business with

with different specifications can be placed in the blister cavities either individually or using a brush-box feeder. The products can also be fed manually, which is mainly an advantage with sample packs or with very small or clinical batches. The NBL 400 from Romaco Noack is capable of

Romaco Macofar MicroMaxX 18 microdosing machineThe Romaco Macofar MicroMaxX 18 microdosing machine processes pharmaceutical powders with different flow properties as well as freeze-dried products and sterile liquids. The system is equipped with a dual dosing disc which allows multiple dosing into the same vial; alternatively, the product can be fil led in two separate process steps. Furthermore, even very small product quantities right down to 25 mg can be dosed precisely. Thanks to an innovative in-line weighing system, one hundred percent weight control is now possible for the first time. The machine achieves a maximum fil l ing speed of 12,000 vials per hour. Up to 18,000 vials an hour are possible in the version with statistical weight control. The Romaco Macofar MicroMaxX 18 can be supplied in different containment designs. Automated processes ensure

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Pharma Bio World46 ◄ November 2018 Pharma Bio World November 2018 ► 47

and capping. It is then pre-compressed and finally converted into finished tablets in the main compression unit. The dwell time is significantly longer owing to the use of Kilian 28/41 tooling, meaning harder tablets can be made. All in all, the Romaco Kilian KTP 590X single-sided rotary press boasts a maximum output of up to 510,000 tablets per hour, even in bi-layer mode.

Romaco Kilian STYL’ONE Evolution tableting robotThe Romaco Kilian STYL’ONE Evolution single-stroke press is the ideal solution for laboratory applications, whether for developing new formulations or for scale-up tests. It achieves a maximum output of 1,750 tablets per hour in configurations for mono-layer, multilayer or core tablets. The compression cycles have been speeded up by more than 60% and the maximum compression force increased to 50 kN in order to simulate high speed presses. Compression force profiles for all standard rotary presses like the Romaco Kilian KTP 420X can now be determined at full power. ANALIS,

reliable operation and meet the high cGMP requirements for dosing sterile powders and liquids.

Romaco Kilian K 720 double-sided rotary pressThe tablet presses in the Romaco Ki l ian K ser ies are special ly tai lored to the needs of the Asian market and impress with their excel lent value for money. The K 720 double-sided rotary press was conf igured by Romaco Ki l ian for the product ion of mono and bi- layer tablets and can be switched f lexibly between the two operat ing modes. This high speed press has a maximum output of 1,000,000 tablets per hour. The technology is used both in the pharmaceut ical industry and in the non-pharmaceut ical sector, and is part icular ly sui ted for compressing effervescent tablets, nutraceut icals and drugstore i tems. The systematic reduct ion of product loss was a top pr ior i ty when Romaco Ki l ian developed the K ser ies. Amongst other features, this is achieved by means of product

scrapers, which are in constant contact with the die table surface due to magnet ic force.

Single-sided rotary press for bi-layer and effervescent tablets: Romaco Kilian KTP 590XThe KTP 590X, a model in the successful KTP-X series from Romaco Kilian. The KTP 590X is an extremely versatile single-sided rotary press which can be used to manufacture both mono-layer and bi-layer tablet formats. Bi-layer tablets can be compressed at any time on the version with three compression rollers. The tablet press is equipped for this purpose with two standard fil l shoe modules, which distribute the powder uniformly in the die. Thanks to the optimised paddle design, even poorly flowing or sticky powders can be processed efficiently and compressed homogeneously. With its three separate compression stations, the Kilian KTP 590X is equally suited for manufacturing effervescent tablets. The powder is tamped initially to prevent air pockets

Romaco Kilian K 720 double-sided rotary press Romaco Kilian KTP 590X single-sided rotary press for bi-layer and effervescent tablets

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Pharma Bio World46 ◄ November 2018 Pharma Bio World November 2018 ► 47

the intelligent PAT software, calculates all relevant tableting parameters based on compression force or displacement controlled cycles. The remarkable precision of the test batches means powder properties can be analysed very realistically. The STYL’ONE Evolution can thus also be util ised to optimise processes or troubleshoot errors.

Romaco Innojet VENTILUS® V 5 processing machineThe VENTILUS® V 5 processing machine from Romaco Innojet is suitable for both aqueous polymer solutions and hot melt coating formulations. The laboratory-scale version of the Romaco Innojet VENTILUS® V 5 is used for particle sizes from 10 µm to 2 mm. Only one product container is required for the granulation, drying and coating steps. Due to its special design and enhanced processing efficiency, the VENTILUS® V 5 allows up to 85% shorter batch times with hot melt coating applications and up to 25% with polymer coatings. The homogeneous

Romaco Kilian STYL’ONE Evolution single-stroke press Romaco Innojet VENTILUS® V 5 processing machine

flow conditions inside the cylindrical product container enable extremely gentle intermixing of the batch and hence play a crucial role here. The air flow bed technology ensures accurate control of the product movement and equally precise application of the spray liquids. The process air is controlled by the ORBITER booster, an ingenious container bottom consisting of overlapping circular plates. Together with the ROTOJET, the central bottom spray nozzle, the booster forms an innovative functional unit that meets all the requirements for linear scale-ups.

(Romaco is a leading international supplier of processing and packaging equipment specialising in engineering technologies for pharmaceutical solids. The group provides individual machines and turnkey solutions for manufacturing and packing powders, granulates, pellets, tablets, capsules, syringes and medical devices. Romaco also serves the food and chemical industries.)

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VOL 16 | ISSUE 04 | NOVEMBER 2017 | MUMBAI | TOTAL PAGES 60 | PRICE ` 150

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