li rw 2006 vat – 3/2006 a novel clinical technique to treat amblyopia dr. roger li bsc(optom), phd...

Li RW 2006

VAT – 3/2006

A Novel Clinical Technique to Treat Amblyopia

Dr. Roger Li BSc(Optom), PhD

Dr. Dennis Levi OD, MS, PhD, FAAO

Collaborators Dr. Pia HoenigDr. Ariella PoppleDr. Karen Young

Li RW 2006

Vernier AcuityCan you see the misalignment?

Offset

Li RW 2006

3AFC Pick the “odd” one out of 3

Offset

Li RW 2006

Positional NoiseJittered Stimulus

Average Position

Li RW 2006

Ext. Noise Levelsint N == spatial distortion

in amblyopic vision

L0 : ext N = 0

L1 : ext N < int N

L2 : ext N ≈ int N

L3 : ext N > int N

Li RW 2006

Noise LevelsLevel 0 (STRAIGHT !!!)

Li RW 2006

Level 1 - slightly jittered

Li RW 2006

Level 2 - somewhat jittered

Li RW 2006

Level 3 - VERY jittered

Li RW 2006

Try This (32-2)

Li RW 2006

Getting Harder! (24-3)

Li RW 2006

Getting Harder & Harder ! (16-3)

Li RW 2006

Getting Harder, Harder & Harder ! (12-1)

Li RW 2006

Getting Harder, Harder, Harder & Harder ! (8-1)

Li RW 2006

???

Modified StaircaseTriplets (up-down rules)

√√√

√√√

√√√

√√√

√√× √××

×××

√√×

Incr

easi

ng

Diff

icul

ty

Trials

Li RW 2006

StaircaseTracking your limits

Diff

icul

t

y

Trials

Easi

er

Hard

er

Li RW 2006

Roll down a hillPerceptual learning

Session (2-hr each)

0 10 20 30 40

Per

form

ance

Sco

re

1

10 L0L1L2L3

Li RW 2006

Practice makes perfectExercise your BRAIN …

Li RW 2006

Can I see better ???Improve Visual Acuity

Session

0 10 20 30 40

Vis

ual

acu

ity

(lo

gM

AR

)

0.2

0.3

0.4

0.5

0.6

0.7

0.8CrowdedUncrowded

S1 S2

Li RW 2006

Effective & Efficient

• Intensive, active, challenging

• Enhance vision in “ 50 ” hrs

• Boost brain processing efficiency

• Decrease cortical image distortion

• Useful in adults & children with Amblyopia

Li RW 2006

Fuuuurther Information

Li RW, Klein SA & Levi DM. (2006) J of Vis, 6, 311-321.

Chung STL, Levi DM & Li RW. (2006) Vis Res, 46, 1038-1047.

Li RW, Young KG, Hoenig P & Levi DM. (2005) IOVS, 46, 3161-3168.

Levi DM. (2005) Dev Psychobiol, 46, 222-232.

Levi DM, Li RW & Klein SA. (2005) Vis Res, 45, 1793-1805.

Li RW & Levi DM. (2004) J of Vis, 4, 476-487.

Li RW, Levi DM & Klein SA. (2004) Nat Neurosci. 7, 178-183.

Li RW 2006

Thank you

Stay tuned to the upcoming

.……. exciting discovery

http://levilab.berkeley.edu