macrophages: biology and role in the pathology of...
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tissue distribution. us conidia; b Macrophage (red) interaction Virus dsRNA (cyan/green) by macrophages; j macroph ages (yellow) in pancreatic ductal tico Humanitas, Rozzano, Italy); f Yolk sac tage (Microglia); i Splenic macrophage. f-i IgN, A *STAR, Singapore)
Subhra K. Biswas • Alberto Mantovani
Editors
Macrophages: Biology and Role in the Pathology of Diseases
~Springer
Preface
rious disease conditions (e.g., tumors, nmation, parasite infection, etc.) and a 1 in disease progression .
. tion and update of our understanding of is both timely and topical in presenting ls in health and disease. ave kindly contributed to this endeavor. the Springer staff who were involved in
Subhra K. Biswas, PhD Alberto Mantovani, MD
Contents
Part I Macrophage: Origin, Activation and Polarization
1 Blood Monocytes and Their Subsets in Health and Disease . . . . . . . . . . . . . . . 3 Loems Ziegler-Heitbrock
2 Polarized Activation of Macro phages .. .. .. .. .. ... .. ....... .. . . ... .. .... .. .. . .. ...... .. . 37 Maria Rosaria Galdiero, Subhra K. Biswas, and Alberto Mantovani
3 Alternative Activation of Macro phages: Concepts and Prospects.. ........... .. ......... ............. ... .... ... ... .... ............. ....... 59 Siamon Gordon, Laura Helming, and Fernando 0. Martinez Estrada
4 Regulatory Macrophages and the Maintenance of Homeostasis ...... .. 77 David M. Mosser and C. Andrew Stewart
Part II Macrophages and Their Diverse Functions
5 Phagocytosis.... .... ... .... .......... ...... ....... .. .. ....... ......... ..... ........ ... ... ..... .... ... .. .. 91 Andrea J. Wolf and David M. Underhill
6 The Antimicrobial Functions of Macrophages. ..... .. .. ... ... ........ ............ . 111 Ronald S. Flannagan
7 Vascular Modulatory Functions of Macro phages. .. ... .... ..... ... ..... .. ... ... . 131 Ioanna Keklikoglou and Michele De Palma
Part III Macrophages in Different Tissues
8 Airway Macrophages: Sentinels of Health .. . .. ...... . .. ... . . .. .. ... ... ... .. ...... .. . 171 Tracy Russell , Thomas J. Bell, and Toshifumi Fujimori
VII
viii Contents
9 Microglial Ontogeny and Functions in Shaping Brain Circuits......... 183 Guillaume Hoeffel, Paola Squarzoni, Sonia Garel, and Florent Ginhoux
10 Kupffer Cells in Health and Disease ...................... .............................. . Andrea M. Woltman, Andre Boonstra, Makoto Naito, and Pieter J.M. Leenen
11 Intestinal Macrophages: Specialized Antigen-Presenting Cells at the Front Line ............................................ .... ...... ............ ........ .. Timothy L. Denning and Bali Pulendran
Part IV Macrophages in Pathology
12 The Wound Macrophage ..... ...... ............................................................ . Meredith J. Crane and Jorge E. Albina
13 Macro phages and the Entrance of Resolution Phase Lipid Mediators ... ......................................... ......... .... ................. .. Charles N. Serhan, Nan Chiang, and Jesmond Dalli
14 Macro phages in Sepsis Progression ...................... .. .. ............................ . Eduardo L6pez-Collazo, Jean-Marc Cavaillon, and Subhra K. Biswas
15 Adaptive Characteristics of Innate Immune Responses in Macro phages ................. ........ ...... .... .............................. ... .. .. .. ....... .. ... . Mihai G. Netea and Alberto Mantovani
16 African Trypanosomiasis as Paradigm for Involvement of the Mononuclear Phagocyte System in Pathogenicity During Parasite Infection ....................................................... .... ........... . Benoit Stijlemans, Alain Beschin, Patrick De Baetselier, and Geert Raes
17 Macrophages in Obesity and Insulin Resistance ................................. . G. Chinetti-Gbaguidi and B. Staels
18 Macrophages Govern the Progression and Termination
217
249
269
287
315
339
349
375
of Inflammation in Atherosclerosis and Metabolic Diseases............... 387 Gabrielle Fredman and Ira Tabas
19 Myelomonocytic Subsets in Tumor Microenvironment........ .. .. ........... 405 Jo A. Van Ginderachter
20 Tumor-Associated Macrophages .......................... ............ ............ ... ...... 425 Antonio Sica, Laura Straus, and Paola Allavena
Contents
Part V Transcriptional ar
21 Role of NF -KB Activat Toby Lawrence
22 Interferon Regulatory Regulation of Macro pi H.L. Eames and I.A. U~
23 Kruppei-Like Factors Lalitha Nayak, Derin T1
24 Regulation of Macrop by the STAT- SOCS Si Sandra E. Nicholson an
25 Functions of the Large and Macro phages ....... Michito Hamada and S1
26 The Control of Gene I Renato Ostuni and Gio1
27 Role of Micro RNA in Graziella Curtale and
Part VI Systems Biology
28 The Macrophage Tra Ronny Milde, Matthiey and Fernando 0. Marti1
29 Omics Approaches to Shakti Gupta, Ashok R Mano Ram Maurya, an
Contents
in Shaping Brain Circuits... .. .... 183 )onia Garel,
Makoto Naito,
Antigen-Presenting
lil
esolution
!smond Dalli
lVaillon,
mmune Responses
m for Involvement m in Pathogenicity
ick De Baetselier,
217
249
269
287
315
339
349
Resistance..... .. ..... .. ....... ... ......... . 375
n and Termination nd Metabolic Diseases....... ... ..... 387
1icroenvironment............... .. .. . ... 405
425 Allavena
Contents ix
Part V Transcriptional and Epigenetic Mechanisms
21 Role of NF -KB Activation in Macrophages.... ..... ............ ...... .............. .. 447 Toby Lawrence
22 Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation .......... ..... ....... .... 463 H.L. Eames and I.A. Udalova
23 Kruppei-Like Factors in Monocyte- Macrophage Biology.................. 487 Lalitha Nayak, Deiin Tugal, and Mukesh K. Jain
24 Regulation of Macrophage Polarization by the STAT - SOCS Signaling Axis .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 497 Sandra E. Nicholson and Peter J. Murray
25 Functions of the Large Maf Transcription Factors and Macro phages .. .. .. . .. .. .. . .. .. . .. . . . .. .. .. . .. .. .. . .. .. .. .. . .. .. .. .. . .. . .. .. . .. .. .. .... . .. .. . .. .. 509 Michito Hamada and Satoru Takahashi
26 The Control of Gene Expression in Macro phages .. .. .. .. .. .. .. .. .. .. .. .. .. . .. .. 5 19 Renato Ostuni and Gioacchino Natoli
27 Role of MicroRNA in Macrophage Activation and Polarization........ 545 Graziella Curtale and Massimo Locati
Part VI Systems Biology of Macrophages
28 The Macrophage Transcriptome .... ........ .. .......... .... ...... .. ............ .... ..... .. 559 Ronny Milde, Matthieu Pesant, Massimo Locati, and Fernando 0. Martinez Estrada
29 Omics Approaches to Macrophage Biology .......... .... .............. ............. . Shakti Gupta, Ashok Reddy Dinasarapu, Merril J. Gersten, Marro Ram Maurya, and Shankar Subramaniam
587
Contents
in Shaping Brain Circuits......... 183 :onia Garel,
Makoto Naito,
Antigen-Presenting
tn
esolution
:smond Dalli
tvaillon,
mmune Responses
m for Involvement m in Pathogenicity
ick De Baetselier,
Resistance .. ............... ... ........ .... . .
n and Termination nd Metabolic Diseases ......... .... ..
Iicroenvironment. ... ......... ...... ... .
AJ.lavena
217
249
269
287
315
339
349
375
387
405
425
Contents ix
Part V Transcriptional and Epigenetic Mechanisms
21 Role of NF-KB Activation in Macrophages............................ .... ........... 447 Toby Lawrence
22 Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation.................. ..... ... 463 H.L. Eames and I.A. Udalova
23 Kruppel-Like Factors in Monocyte- Macrophage Biology... ... .... ........ 487 Lalitha Nayak, Derin Tugal, and Mukesh K. Jain
24 Regulation of Macrophage Polarization by the STAT - SOCS Signaling Axis .. .. .. .. .. .. .. .. . .. .. . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 497 Sandra E. Nicholson and Peter J. Murray
25 Functions of the Large Maf Transcription Factors and Macro phages .. .. . .. . . . . .. .. .. .. .. . .. . . .. . .. .. . . . .. .. .. . . .. . .. .. . .. .. .. . .. . .. .. .. .. ... .. .. . .. .. . . 509 Michito Hamada and Satoru Takahashi
26 The Control of Gene Expression in Macro phages .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 5 19 Renato Ostuni and Gioacchino Natoli
27 Role of MicroRNA in Macrophage Activation and Polarization........ 545 Graziella Curtale and Massimo Locati
Part VI Systems Biology of Macrophages
28 The Macrophage Transcriptome .... ........ ............ .... .... .. ........ ........ .. ....... 559 Ronny Milde, Matthieu Pesant, Massimo Locati, and Fernando 0. Martinez Estrada
29 Omics Approaches to Macrophage Biology.................................... .. .... 587 Shakti Gupta, Ashok Reddy Dinasarapu, Merril J. Gersten, Mano Ram Maurya, and Shankar Subramaniam
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